Zusammenfassung
Lungenkarzinome als weltweit häufigste bösartige Tumorerkrankung teilen sich histologisch in das nichtkleinzellige und das kleinzellige Bronchialkarzinom, das bronchoalveoläre Karzinom und das neuroendokrine Karzinom. Die FDG-PET/CT wird bei Verdacht auf einen primären Lungentumor zunehmend in die bisherigen bildgebenden Modalitäten (CT, Bronchoskopie, Mediastinoskopie, MRT, Knochenszintigraphie) zur weiteren Diagnosesicherung eingebunden. Die PET/CT zeichnet sich beim T-, N- und M-Staging durch einen Informationsgewinn und damit durch eine höhere Vorhersage- bzw. Ausschlussquote aus. Lymphknotenmetastasen außerhalb des Mediastinums sowie Nebennieren-, Knochen- und Knochenmarkmetastasen spielen eine therapieentscheidende Rolle im primären Staging. Besonders in der Planung der Strahlentherapie von Lungenkarzinomen leistet die FDG-PET/CT einen essenziellen Beitrag. Nach potenziell kurativer Therapie hat sie Einfluss auf das weitere Management und die Prognosestratifikation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Antoch G, Stattaus J, Nemat AT et al. (2003) Non-small cell lung cancer: Dual modality PET/CT in preoperative staging. Radiology 229: 526–533
Bundesamt fur Strahlenschutz (2001) Teil B - IV - Strahlenexposition durch medizinische Masnahmen. http://www.bfs.de/de/bfs/publikationen/berichte/umweltradioaktivitaet/JB10TeilB_IV.pdf (Zugriff: 22.03.2015)
Bundesamt fur Strahlenschutz (2012) Bekanntmachung der aktualisierten diagnostischen Referenzwerte fur nuklearmedizinische Untersuchungen. http://www.bfs.de/de/ion/medizin/diagnostik/drw_nuklearmedizin.pdf (Zugriff: 22.03.2015)
Cuaron J, Dunphy M, Rimner A (2012) Role of FDG-PET scans in staging, response assessment, and follow-up care for non-small cell lung cancer. Front Oncol 2: 208
Czernin J (2007) PET/CT in cancer patient management. J Nucl Med: 1S–88 S
Czernin J, Auerbach MA (2005) Clinical PET/CT imaging: Promises and misconceptions. Nuklearmedizin 44 (suppl 1): S18–23
Czernin J, Allen-Auerbach M, Schelbert HR (2007) Improvements in cancer staging with PET/CT: Literature-based evidence as of September 2006. J Nucl Med 48 (suppl 1): 78S–88 S
Deppen SA, Blume JD, Kensinger CD et al. (2014) Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis. JAMA 312(12): 1227–1236
Deutsches Arzteblatt (2013) Malignes Pleuramesotheliom: Inzidenz, Atiologie, Diagnostik, Therapie und Arbeitsmedizin. http://www.aerzteblatt.de/archiv/137725/Malignes-Pleuramesotheliom- Inzidenz-Aetiologie-Diagnostik-Therapie-und-Arbeitsmedizin (Zugriff: 22.03.2015)
Deutsche Krebsgesellschaft (2008) Kurzgefasste interdisziplinare Leitlinien 2008. Deutsche Krebsgesellschaft. http://www.krebsgesellschaft.de/wub_llkurz_2008,120883.html (Zugriff: 25.01.2010)
Erasmus JJ, Page Mc Adams H, Rossi SE, Goodman PC et al. (2000) FDG PET of pleural effusions in patients with non-small cell lung cancer. Am J Roentgenol 175: 245–249
Facey K, Bradbury I, Laking G, Payne E (2007) Overview of the clinical effectiveness of positron emission tomography imaging in selected cancers. Health Technol Assess Winch Engl 11(44): iii-iv, xi–267
Fleckenstein J, Hellwig D, Kremp S et al. (2011) F-18-FDG-PET confined radiotherapy of locally advanced NSCLC with concomitant chemotherapy: results of the PET-PLAN pilot trial. Int J Radiat Oncol Biol Phys 81(4): e283–e289
Gemeinsamer Bundesausschuss (2007) Positronenemissionstomographie (PET). Abschlussbericht des Unterausschusses »Arztliche Behandlung« des Gemeinsamen Bundesausschusses. https://www.g-ba.de/downloads/40-268-514/2007-12-13-Abschluss- PET-NSCLC.pdf (Zugriff: 24.03.2015)
Gemeinsamer Bundesausschuss (2008) Positronenemissionstomographie SCLC. Zusammenfassende Dokumentation. https://www.g-ba.de/downloads/40-268-682/2008-05-26-Abschluss- PET-SCLC.pdf (Zugriff: 24.03.2015)
Gerbaudo VH, Sugarbaker DJ, Britz-Cunningham S et al. (2002) Assessment of malignant pleural mesothelioma with 18F-FDG dual-head gamma-camera coincidence imaging: comparison with histopathology. J Nucl Med 43: 1144–1149
Goeckenjan G, Sitter H, Thomas M et al. (2011) Pravention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms. Pneumologie 2011: 65: 51–75
Hany TF, Steinert HC, Goerres GW, Buck A, von Schulthess GK (2002) PET diagnostic accuracy: improvement with in-line PET-CT system: initial results. Radiology 225(2): 575–581
Hellwig D, Baum RP, Kirsch C (2009) FDG-PET, PET/CT and conventional nuclear medicine procedures in the evaluation of lung cancer: a systematic review. Nukl Nucl Med 48(2): 59–69, quiz N8–N9
Huang W, Liu B, Fan M et al. (2015) The early predictive value of a decrease of metabolic tumor volume in repeated (18)F-FDG PET/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy. Eur J Radiol 84(3): 482–488. doi:10.1016/j.ejrad.2014.11.020
Im H-J, Pak K, Cheon GJ et al. (2015) Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis. Eur J Nucl Med Mol Imaging 42(2): 241–251
Ji C, Zhang B, Zhu W et al. (2014) Evaluation of (18)F-fluorodeoxyglucose uptake in enlarged mediastinal lymph nodes in patients with lung cancer. Int J Clin Exp Pathol 7(11): 8227–8234
Kim M-H, Lee JS, Mok JH et al. (2014) Metabolic burden measured by (18)f-fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in patients with small cell lung cancer. Cancer Res Treat Off J Korean Cancer Assoc 46(2): 165–171
Klabatsa A, Chicklore S, Barrington SF, Goh V, Lang-Lazdunski L, Cook GJR (2014) The association of 18F-FDG PET/CT parameters with survival in malignant pleural mesothelioma. Eur J Nucl Med Mol Imaging 41(2): 276–282
Klett R, Rohrl A, Bauer R (2000) Nachtliche und belastungsbedingte pektanginose Beschwerden durch vertebragene Dysfunktion. Herz/Kreislauf 32: 309–311
Krause BJ, Schwarzenbock S, Souvatzoglou M (2013) FDG PET and PET/CT. Recent Results Cancer Res Fortschritte Krebsforsch Prog Dans Rech Sur Cancer 187: 351–369. doi:10.1007/978-3-642- 10853-2_12
Kruger S, Buck AK, Mottaghy FM et al. (2009) Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging 36(11): 1807–1812
Kung BT, Auyong TK, Tong CM (2014) Prevalence of Detecting Unknown Cerebral Metastases in Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and its Potential Clinical Impact. World J Nucl Med 13(2): 108–111. doi:10.4103/1450-1147.139141
Lardinois D, Weder W, Hany TF et al. (2003) Staging of non-small cell lung cancer with integrated positron emission tomography and computed tomography. N Engl J Med 348: 2500–2507
Larson SM, Erdi Y, Akhurst T et al. (1999) Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis. Clin Positron Imaging Off J Inst Clin PET 2(3): 159–171
Li J, Xu W, Kong F, Sun X, Zuo X (2013) Meta-analysis: accuracy of 18FDG PET-CT for distant metastasis staging in lung cancer patients. Surg Oncol 22(3): 151–155
Liu S, Cheng H, Yao S et al. (2010) The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features. Ann Nucl Med 24(7): 541–547
Lv Y-L, Yuan D-M, Wang K et al. (2011) Diagnostic performance of integrated positron emission tomography/computed tomography for mediastinal lymph node staging in non-small cell lung cancer: a bivariate systematic review and meta-analysis. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer 6(8):1350–1358
Mac Manus MP, Hicks RJ (2012) The role of positron emission tomography/computed tomography in radiation therapy planning for patients with lung cancer. Semin Nucl Med 42(5): 308–319
Marcus C, Paidpally V, Antoniou A, Zaheer A, Wahl RL, Subramaniam RM (2015). 18F-FDG PET/CT and Lung Cancer: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management. J Nucl Med Off Publ Soc Nucl Med 56(2): 204–208. doi:10.2967/jnumed.114.147884
Minamimoto R, Senda M, Jinnouchi S et al. (2014) Detection of lung cancer by FDG-PET cancer screening program: a nationwide Japanese survey. Anticancer Res 34(1): 183–189
Nguyen P, Bhatt M, Bashirzadeh F et al. (2015) Comparison of objective criteria and expert visual interpretation to classify benign and malignant hilar and mediastinal nodes on 18-F FDG PET/CT. Respirol Carlton Vic 20(1): 129–137. doi:10.1111/resp.12409
Ordu C, Selcuk NA, Erdogan E et al. (2014) Does early PET/CT assesment of response to chemotherapy predicts survival in patients with advanced stage non-small-cell lung cancer? Medicine 93(28): e299. doi:10.1097/MD.0000000000000299
van Overhage H, Broekel K, Heijenbrok MW et al. (2004) Metastases in supraclavicular lymphnodes in lung cancer: Assessment with palpation, US and CT. Radiology 232: 75–80
Qu X, Huang X, Yan W, Wu L, Dai K (2012) A meta-analysis of 18FDG-PET-CT, 18FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with lung cancer. Eur J Radiol 81(5): 1007–1015
Pitts A, Ih G, Wei M et al. (2013) Clinical utility of FDG-PET for diagnosis of adrenal mass: a large single-center experience. Horm Athens Greece 12(3): 417–427
Robert Koch-Institut, Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (2013) Krebs in Deutschland 2009/2010. Beitrage zur Gesundheitsberichterstattung des Bundes. 9. Ausg. Berlin, S 60–63. http://www.rki.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/kid_2013/krebs_in_ deutschland_2013.pdf;jsessionid = 8D65E3DB2765A1D4C6CE- 39F27AB011D8.2_cid372?__blob = publicationFile (Zugriff: 18.03.2015)
Sawada E, Nambu A, Motosugi U et al. (2010) Localized mucinous bronchioloalveolar carcinoma of the lung: thin-section computed tomography and fluorodeoxyglucose positron emission tomography findings. Jpn J Radiol 28(4): 251–258
Schaffler GJ, Wolf G, Schoellnast H et al. (2004) Non-small cell lung cancer: Evaluation of pleural abnormalities on CT scans with 18F FDG PET. Radiology 231: 858–865
Schmidt-Hansen M, Baldwin DR, Hasler E, Zamora J, Abraira V, Roque I Figuls M (2014) PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable nonsmall cell lung cancer. Cochrane Database Syst Rev 11:CD009519
Shimizu K, Maeda A, Yukawa T et al. (2014) Difference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose- positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma. World J Surg Oncol 12: 343
Shreve P, Faasse T (2013) Role of positron emission tomographycomputed tomography in pulmonary neoplasms. Radiol Clin North Am 51(5): 767–779
Sim YT, Goh YG, Dempsey MF, Han S, Poon FW (2013) PET-CT evaluation of solitary pulmonary nodules: correlation with maximum standardized uptake value and pathology. Lung 191(6): 625–632. doi:10.1007/s00408-013-9500-6
Skoura EV, Exarhos D, Skilakaki M et al. (2009) Contribution of 18F-PET/CT in the management of patients with bronchioalveolar carcinoma (BAC): work in progress. Eur J Nucl Med Mol Imaging, Abstracts Ann Congr EANM 2009: P118, S333
Terada T, Tabata C, Tabata R et al. (2012) Clinical utility of 18-fluorodeoxyglucose positron emission tomography/computed tomography in malignant pleural mesothelioma. Exp Ther Med 4(2): 197–200
van Tinteren H, Hoekstra OS, Smit EF et al. (2002) Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non small cell lung cancer: The PLUS multicentre randomized trial. Lancet 359: 1388–1392
Toba H, Kondo K, Otsuka H et al. (2010) Diagnosis of the presence of lymph node metastasis and decision of operative indication using fluorodeoxyglucose-positron emission tomography and computed tomography in patients with primary lung cancer. J Med Investig JMI 57(3–4): 305–313
Van Baardwijk A, Reymen B, Wanders S et al. (2012) Mature results of a phase II trial on individualised accelerated radiotherapy based on normal tissue constraints in concurrent chemo-radiation for stage III non-small cell lung cancer. Eur J Cancer Oxf Engl 48 (15): 2339–2346
Van Gool MH, Aukema TS, Hartemink KJ, Valdes Olmos RA, van Tinteren H, Klomp HM (2014) FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC. World J Radiol 6(7): 392–398
Verboom P, van Tinteren H, Hoekstra OS et al. (2003) Cost-effectiveness of FDG-PET in staging non-small cell lung cancer: the PLUS study. Eur J Nucl Med Mol Imaging 30(11): 1444–1449. doi:10.1007/s00259-003-1199-9
Wahl RL (2004) Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT. J Nucl Med (suppl 1) 45: 82S–95 S
Wever WD, Stroobants S, Coolen J, Verschakelen JA (2009) Integrated PET/CT in the staging of nonsmall cell lung cancer: technical aspects and clinical integration. Eur Respir J 33(1): 201–212
Yu J, Li X, Xing L et al. (2009) Comparison of tumor volumes as determined by pathologic examination and FDG-PET/CT images of non-small-cell lung cancer: a pilot study. Int J Radiat Oncol Biol Phys 75(5): 1468–1474
Zahid I, Sharif S, Routledge T, Scarci M (2011) What is the best way to diagnose and stage malignant pleural mesothelioma? Interact Cardiovasc Thorac Surg 12(2): 254–259
Zhang H, Wroblewski K, Liao S et al. (2013) Prognostic value of metabolic tumor burden from (18)F-FDG PET in surgical patients with non-small-cell lung cancer. Acad Radiol 20(1): 32–40
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mohnike, W., Hör, G., Hertel, A. (2016). Lungentumoren. In: Mohnike, W., Hör, G., Hertel, A., Schelbert, H. (eds) PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48842-3_6
Download citation
DOI: https://doi.org/10.1007/978-3-662-48842-3_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-48841-6
Online ISBN: 978-3-662-48842-3
eBook Packages: Medicine (German Language)