Skip to main content

Lokale Bildgebung beim Rektumkarzinom – Update 2015

MRT als „Imaging“-Biomarker

  • Chapter
Weiterbildung Radiologie
  • 2572 Accesses

Zusammenfassung

Die Bedeutung der spezialisierten Magnetresonanztomographie (MRT) beim Rektumkarzinom geht heute weit über die Detektion und die lokale Ausbreitungsdiagnostik hinaus und nimmt in zunehmendem Maße die Patientenprognose in den Fokus. Die Identifikation prognostischer Faktoren, unter die der Tumor- und der Nodalstatus, der Befall der Resektionsränder, das Vorhandensein einer extramuralen vaskulären Infiltration, der Tumorregressionsgrad nach neoadjuvanter Therapie sowie die Veränderungen von Mikrozirkulation, Permeabilität und Gewebezellularität im Gefolge einer Behandlung fallen, sind neben den Bestrebungen, strukturierte Befundung flächendeckend einzuführen, bedeutende Elemente der modernen Diagnostik des Rektumkarzinoms und heben die MRT in den Rang eines „Imaging“-Biomarkers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 9.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 17.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Schäfer AD, Baumann 1, Pache G et al (2007) Präoperatives Staging des Rektumkarzinoms. Radiologe 47:635–651

    Google Scholar 

  2. Schäfer AD, Langer M, Baumann T (2012) Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms. Chirurg 83:439–447

    Article  PubMed  Google Scholar 

  3. Wolf M, Zehentmayr F, Belka C (2012) Strahlentherapie des Rektumkarzinoms. Radiologe 52:545–549

    Article  CAS  PubMed  Google Scholar 

  4. Karpitschka M (2012) Rektumkarzinom - Lokales Staging und Bildgebung unter neoadjuvanter Therapie. Radiologe 52:5 19–528

    Google Scholar 

  5. Bugg WG, Andreou AK, Biswas D et al (2014) The prognostic significance of MRI-detected extramural venous invasion in rectal carcinoma. Clin Radiol 69:619–623

    Article  CAS  PubMed  Google Scholar 

  6. Battersby NJ, How P, Moran B et al (2015) Prospective validation of a low rectal cancer magnetic resonance imaging staging system and development of a local recurrence risk stratification model: the MERCURY II study (Epub ahead of print PMID: 25822672)

    Google Scholar 

  7. Glimelius B, Tiret E, Cervantes A, Arnold D, ESMO Guidelines Working Group (2013) Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 24:81–88

    Google Scholar 

  8. Glynne-Jones R, Tan D, Goh V (2014) Pelvic MRI for guiding treatment decisions in rectal cancer. Oncology (Williston Park) 28:667–677

    PubMed  Google Scholar 

  9. Battersby NJ, Balyasnikova S, Brown G (2014) Guiding post-treatment decisions in rectal cancer: mrTRG is apractical place to start. Oncology (Williston Park) 28:677–680

    PubMed  Google Scholar 

  10. Taylor FG, Quirke P, Heald RJ et al (2011) Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surg eryalone: aprospective, multicenter, European study. Ann Surg 253:711–719

    Article  PubMed  Google Scholar 

  11. Sohn B, Lim JS, Kim H et al (2015) MRI-detected extramural vascular invasion is an independent prognostic factor for synchronous metastasis in patients with rectal cancer. Eur Radiol 25:1347–1355

    Article  PubMed  Google Scholar 

  12. Chand M, Swift RI, Tekkis PP et al (2014) Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer. Br J Cancer 7(110):19–25

    Article  Google Scholar 

  13. Chand M, Evans J, Swift RI et al (2014) The prognostic significance of postchemoradiotherapy highresolution MRI and histopathology detected extramural venous invas ion in rectal cancer. Ann Surg 261:473–479

    Article  Google Scholar 

  14. Park JS, Huh JW, Park YA et al (2015) Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer. Medicine (Baltimore) 94(15):e658

    Article  CAS  Google Scholar 

  15. Tawadros PS, Paquette IM, Hanly AM et al (2015) Adenocarcinoma of the rectum in patients under age 40 is increasing: impact of signet-ring cell histology. Dis Colon Rectum 58:474–478

    Article  PubMed  Google Scholar 

  16. Talbot Ie, Ritchie S, Leighton MH (1980) The clinical significance of invasion of veins byrectal cancer. Br J Surg 67:439–442

    Article  CAS  PubMed  Google Scholar 

  17. Koh DM, Smith NJ, Swift RI, Brown G(2008) The relationship between MR demonstration of extramural venous invasion and nodal disease in rectal cancer. Clin Med Oncol 2:267–273

    Google Scholar 

  18. Fichera A, Allaix ME (2014) Paradigm- shifting new evidence for treatment of rectal cancer. J Gastrointest Surg 18:391–397

    Article  PubMed  Google Scholar 

  19. Patel UB, Blomqvist LK, Taylor F et al (2012) MRI after treatment of locally advanced rectal cancer: how to report tumor responsethe MERCURY experience. Ajr Am J Roentgenol 199:486–495

    Article  Google Scholar 

  20. Patel UB, Taylor F, Blomquvist L et al (2011) Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience. J Clin Oncol 29:3753–3760

    Article  PubMed  Google Scholar 

  21. Habr-Gama A, Sabbaga J, Gama Rodrigues J et al (2013) Watch and wait approach following extended neoadjuvant chemoradiation for distal rectal cancer: are we getting closer to anal cancer management. Dis Colon Rectum 56:1109–1117

    Article  PubMed  Google Scholar 

  22. Habr-Gama A, Gama-Rodrigues J, São Julião GP et al (2014) Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemorad iation: impact of salvage therapy on local disease control.lnt J Radiat Oncol Bioi Phys 88:822–828

    Google Scholar 

  23. Hötker AM, Garcia-Aguilar J, Gollub MJ (2014) Multiparametric MRI of rectal cancer in the assessment of response to therapy: a systematic review. Dis Colon Rectum 57:790–799

    Article  PubMed  Google Scholar 

  24. Attenberger UI, Pilz LR, Morelli IN (2014) Multi-parametric MRI of rectal cancer - do quantitative functional MR measurements correlate with radiologic and pathologic tumor stages. Eur J Radiol83:1 036 – 1 043

    Google Scholar 

  25. Intven M, Monninkhof EM, Reerink O, Philippens ME (2015) Combined T2wvolumetry, DW-MRI and DCEMRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer. Acta Oncol. (Epub ahead of print PMID: 25914930)

    Google Scholar 

  26. AI-Sukhni E, Brown G, Milot L et al (2012) User’s guide for the synoptic MRI report for rectal cancer. Joint initiative of Cancer Care Ontario and Canadian Cancer Society. https://www.cancercare. on.ca.Zugegriffen: 14.10.2015

  27. Kennedy ED, Milot L, Fruitman M et al (2014) Development and implementation of a synoptic MRI report for preoperative staging of rectal cancer on a population-based level. Dis Colon Rectum 57:700–708

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schäfer, AO. (2017). Lokale Bildgebung beim Rektumkarzinom – Update 2015. In: Delorme, S., Reimer, P., Reith, W., Schäfer-Prokop, C., Schüller-Weidekamm, C., Uhl, M. (eds) Weiterbildung Radiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52752-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-52752-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-52751-1

  • Online ISBN: 978-3-662-52752-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics