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Peritoneal Malignancies and Colorectal Peritoneal Metastases

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Coloproctology

Part of the book series: European Manual of Medicine ((EUROMANUAL))

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Abstract

The majority of patients with pseudomyxoma peritonei of appendiceal origin who have complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are cured. There is increasing evidence to support that similar principles of surgery and intraperitoneal chemotherapy can be effective in patients with peritoneal mesothelioma and colorectal peritoneal metastases. The key to a successful outcome is complete cytoreduction. This chapter discusses the evidence behind cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, mainly in colorectal peritoneal metastases, and the challenges associated in selecting patients in whom this strategy is appropriate.

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References

  1. Jayne DG, Fook S, Loi C, Seow-Choen F. Peritoneal carcinomatosis from colorectal cancer. Br J Surg. 2002;89(12):1545–50.

    Article  CAS  PubMed  Google Scholar 

  2. Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J, et al. Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000;88(2):358–63.

    Article  CAS  PubMed  Google Scholar 

  3. Koppe MJ, Boerman OC, Oyen WJ, Bleichrodt RP. Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg. 2006;243(2):212–22.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Klaver YL, Leenders BJ, Creemers GJ, Rutten HJ, Verwaal VJ, Lemmens VE, et al. Addition of biological therapies to palliative chemotherapy prolongs survival in patients with peritoneal carcinomatosis of colorectal origin. Am J Clin Oncol. 2013;36(2):157–61.

    Article  CAS  PubMed  Google Scholar 

  5. Moran BJ, Cecil TD. Treatment of surgically resectable colorectal peritoneal metastases. Br J Surg. 2014;101(2):5–7.

    Article  CAS  PubMed  Google Scholar 

  6. Sugarbaker PH. Pseudomyxoma peritonei. A cancer whose biology is characterized by a redistribution phenomenon. Ann Surg. 1994;219(2):109–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Youssef H, Newman C, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ. Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum. 2011;54(3):293–9.

    Article  PubMed  Google Scholar 

  8. Klaver YL, Hendriks T, Lomme RM, Rutten HJ, Bleichrodt RP, de Hingh IH. Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model. Br J Surg. 2010;97(12):1874–80.

    Article  CAS  PubMed  Google Scholar 

  9. Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol: Off J Am Soc Clin Oncol. 2003;21(20):3737–43.

    Article  Google Scholar 

  10. Yan TD, Black D, Savady R, Sugarbaker PH. A systematic review on the efficacy of cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol. 2007;14(2):484–92.

    Article  PubMed  Google Scholar 

  11. Mirnezami R, Moran BJ, Harvey K, Cecil T, Chandrakumaran K, Carr N, et al. Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases. World J Gastroenterol: WJG. 2014;20(38):14018–32.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Verwaal VJ, Bruin S, Boot H, van Slooten G, van Tinteren H. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15(9):2426–32.

    Article  PubMed  Google Scholar 

  13. Elias D, Lefevre JH, Chevalier J, Brouquet A, Marchal F, Classe JM, et al. Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin. J Clin Oncol: Off J Am Soc Clin Oncol. 2009;27(5):681–5.

    Article  Google Scholar 

  14. Franko J, Ibrahim Z, Gusani NJ, Holtzman MP, Bartlett DL, Zeh 3rd HJ. Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis. Cancer. 2010;116(16):3756–62.

    Article  PubMed  Google Scholar 

  15. Mahteme H, Hansson J, Berglund A, Pahlman L, Glimelius B, Nygren P, et al. Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study. Br J Cancer. 2004;90(2):403–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Goere D, Malka D, Tzanis D, Gava V, Boige V, Eveno C, et al. Is there a possibility of a cure in patients with colorectal peritoneal carcinomatosis amenable to complete cytoreductive surgery and intraperitoneal chemotherapy? Ann Surg. 2013;257(6):1065–71.

    Article  PubMed  Google Scholar 

  17. Riss S, Mohamed F, Dayal S, Cecil T, Stift A, Bachleitner-Hofmann T, et al. Peritoneal metastases from colorectal cancer: patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Eur J Surg Oncol:J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2013;39(9):931–7.

    Article  CAS  Google Scholar 

  18. Mirnezami R, Mehta AM, Chandrakumaran K, Cecil T, Moran BJ, Carr N, et al. Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy improves survival in patients with colorectal peritoneal metastases compared with systemic chemotherapy alone. Br J Cancer. 2014;111(8):1500–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Canda AE, Sokmen S, Terzi C, Arslan C, Oztop I, Karabulut B, et al. Complications and toxicities after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2013;20(4):1082–7.

    Article  PubMed  Google Scholar 

  20. Bakrin N, Bereder JM, Decullier E, Classe JM, Msika S, Lorimier G, et al. Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2013;39(12):1435–43.

    Article  CAS  Google Scholar 

  21. Sugarbaker PH. Peritonectomy procedures. Cancer Treat Res. 1996;82:235–53.

    Article  CAS  PubMed  Google Scholar 

  22. Mohamed F, Cecil T, Moran B, Sugarbaker P. A new standard of care for the management of peritoneal surface malignancy. Curr Oncol. 2011;18(2):e84–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. El-Kareh AW, Secomb TW. A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance. Neoplasia. 2004;6(2):117–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Pelz JO, Vetterlein M, Grimmig T, Kerscher AG, Moll E, Lazariotou M, et al. Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis: role of heat shock proteins and dissecting effects of hyperthermia. Ann Surg Oncol. 2013;20(4):1105–13.

    Article  PubMed  Google Scholar 

  25. Elias D, Gilly F, Boutitie F, Quenet F, Bereder JM, Mansvelt B, et al. Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol: Off J Am Soc Clin Oncol. 2010;28(1):63–8.

    Article  Google Scholar 

  26. Jacquet P, Sugarbaker PH. Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res. 1996;82:359–74.

    Article  CAS  PubMed  Google Scholar 

  27. Goere D, Souadka A, Faron M, Cloutier AS, Viana B, Honore C, et al. Extent of colorectal peritoneal carcinomatosis: attempt to define a threshold above which HIPEC does not offer survival benefit: a comparative study. Ann Surg Oncol. 2015;22:2958–64.

    Article  PubMed  Google Scholar 

  28. Pelz JO, Stojadinovic A, Nissan A, Hohenberger W, Esquivel J. Evaluation of a peritoneal surface disease severity score in patients with colon cancer with peritoneal carcinomatosis. J Surg Oncol. 2009;99(1):9–15.

    Article  PubMed  Google Scholar 

  29. Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, et al. The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 patients with colorectal cancer with peritoneal carcinomatosis. Ann Surg Oncol. 2014;21(13):4195–201.

    Article  PubMed  Google Scholar 

  30. Verwaal VJ, van Tinteren H, van Ruth S, Zoetmulder FA. Predicting the survival of patients with peritoneal carcinomatosis of colorectal origin treated by aggressive cytoreduction and hyperthermic intraperitoneal chemotherapy. Br J Surg. 2004;91(6):739–46.

    Article  CAS  PubMed  Google Scholar 

  31. Cashin PH, Graf W, Nygren P, Mahteme H. Patient selection for cytoreductive surgery in colorectal peritoneal carcinomatosis using serum tumor markers: an observational cohort study. Ann Surg. 2012;256(6):1078–83.

    Article  PubMed  Google Scholar 

  32. Ihemelandu CU, McQuellon R, Shen P, Stewart JH, Votanopoulos K, Levine EA. Predicting postoperative morbidity following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CS+HIPEC) with preoperative FACT-C (Functional Assessment of Cancer Therapy) and patient-rated performance status. Ann Surg Oncol. 2013;20(11):3519–26.

    Article  PubMed  Google Scholar 

  33. Passot G, You B, Boschetti G, Fontaine J, Isaac S, Decullier E, et al. Pathological response to neoadjuvant chemotherapy: a new prognosis tool for the curative management of peritoneal colorectal carcinomatosis. Ann Surg Oncol. 2014;21(8):2608–14.

    Article  PubMed  Google Scholar 

  34. Koh JL, Yan TD, Glenn D, Morris DL. Evaluation of preoperative computed tomography in estimating peritoneal cancer index in colorectal peritoneal carcinomatosis. Ann Surg Oncol. 2009;16(2):327–33.

    Article  PubMed  Google Scholar 

  35. Chang-Yun L, Yonemura Y, Ishibashi H, Sako S, Tsukiyama G, Kitai T, et al. Evaluation of preoperative computed tomography in estimating peritoneal cancer index in peritoneal carcinomatosis. Gan to kagaku ryoho Cancer Chemother. 2011;38(12):2060–4.

    Google Scholar 

  36. Rivard JD, Temple WJ, McConnell YJ, Sultan H, Mack LA. Preoperative computed tomography does not predict resectability in peritoneal carcinomatosis. Am J Surg. 2014;207(5):760–4; discussion 4–5.

    Article  PubMed  Google Scholar 

  37. Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of surgical oncology. Ann Surg Oncol. 2007;14(1):128–33.

    Article  CAS  PubMed  Google Scholar 

  38. Pfannenberg C, Konigsrainer I, Aschoff P, Oksuz MO, Zieker D, Beckert S, et al. (18)F-FDG-PET/CT to select patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2009;16(5):1295–303.

    Article  PubMed  Google Scholar 

  39. Valle M, Garofalo A. Laparoscopic staging of peritoneal surface malignancies. Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2006;32(6):625–7.

    Article  Google Scholar 

  40. Iversen LH, Rasmussen PC, Laurberg S. Value of laparoscopy before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis. Br J Surg. 2013;100(2):285–92.

    Article  CAS  PubMed  Google Scholar 

  41. Elias D, Benizri E, Pocard M, Ducreux M, Boige V, Lasser P. Treatment of synchronous peritoneal carcinomatosis and liver metastases from colorectal cancer. Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2006;32(6):632–6.

    Article  CAS  Google Scholar 

  42. Maggiori L, Goere D, Viana B, Tzanis D, Dumont F, Honore C, et al. Should patients with peritoneal carcinomatosis of colorectal origin with synchronous liver metastases be treated with a curative intent? A case-control study. Ann Surg. 2013;258(1):116–21.

    Article  PubMed  Google Scholar 

  43. Elias D, Honore C, Dumont F, Ducreux M, Boige V, Malka D, et al. Results of systematic second-look surgery plus HIPEC in asymptomatic patients presenting a high risk of developing colorectal peritoneal carcinomatosis. Ann Surg. 2011;254(2):289–93.

    Article  CAS  PubMed  Google Scholar 

  44. Coleman MG, Hanna GB, Kennedy R, National Training Programme L. The national training programme for laparoscopic colorectal surgery in England: a new training paradigm. Colorectal Dis: Off J Assoc Coloproctol G B Irel. 2011;13(6):614–6.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Peritoneal Malignancy Institute, Basingstoke, RG24 9NA, UK

    Sanjeev Dayal MD, Lily Maguire MD & Brendan Moran MD

Authors
  1. Sanjeev Dayal MD
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  2. Lily Maguire MD
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  3. Brendan Moran MD
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Corresponding author

Correspondence to Brendan Moran MD .

Editor information

Editors and Affiliations

  1. End- und Dickdarm-Zentrum Mannheim, Mannheim, Germany

    Alexander Herold

  2. Clinique de chirurgie digestive et endocrinienne, Institut des maladies de l’appareil digestif, Hotel Dieu, Nantes, France

    Paul-Antoine Lehur

  3. Chirurgische Klinik mit Poliklinik, Universitaet Erlangen, Erlangen, Germany

    Klaus E. Matzel

  4. UCD School of Medicine, St Vincent’s University Hospital, Dublin, Ireland

    P. Ronan O'Connell

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Dayal, S., Maguire, L., Moran, B. (2017). Peritoneal Malignancies and Colorectal Peritoneal Metastases. In: Herold, A., Lehur, PA., Matzel, K., O'Connell, P. (eds) Coloproctology. European Manual of Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53210-2_28

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  • DOI: https://doi.org/10.1007/978-3-662-53210-2_28

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53208-9

  • Online ISBN: 978-3-662-53210-2

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