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Comparison of Intrathecal Dotarizine and Nimodipine Treatments in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study in Rabbits

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Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/2))

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Abstract

Background: Cerebral vasospasm (CVS) is one of the most considerable complications of subarachnoid hemorrhage (SAH). The aim of this study was to assess and to compare the ability of intrathecal dotarizine and nimodipine to prevent and treat vasospasm in a rabbit model of subarachnoid hemorrhage.

Method: Thirty male New Zealand white rabbits weighing 2,500–3,000 g were allocated into five groups randomly. The treatment groups were as follows: Control, only SAH, SAH/Dotarizine, SAH/Nimodipine, SAH/Vehicle. Forty-eight hours after SAH injection, all animals underwent femoral artery catheterization procedure by open surgery under anesthesia and angiography performed for each animal in the fifth day just before sacrifice.

Findings: Basilar artery vessel diameters are measured by angiography. Basilar artery vessel diameters and luminal sectional areas are measured in pathology slides. There was a statistically significant difference between the mean basilar artery cross-sectional areas and the mean arterial wall thickness measurements of the control and SAH-only groups (p < 0.05).

Conclusions: These findings demonstrate that calcium channel blocker dotarizine has marked vasodilatory effect in an experimental model of SAH in rabbits. Nimodipine is an effect-proven agent in CVS, but dotarizine may take place of it.

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Authors and Affiliations

  1. Department of Neurosurgery, Gulhane Military Academy, Ugur Mumcunun Sokak, 78/2, 06700, Gaziosmanpasa, Ankara, Turkey

    Mehmet Bulent Onal, Ilker Solmaz, Erdinc Civelek, Atilla Kircelli, Yusuf Izci, Ersin Erdogan & Engin Gonul

  2. Erzurum Military Hospital, Erzurum, Turkey

    Ozkan Tehli

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  1. Mehmet Bulent Onal
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  2. Ilker Solmaz
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  4. Atilla Kircelli
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Correspondence to Mehmet Bulent Onal .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    Hua Feng

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Onal, M.B. et al. (2011). Comparison of Intrathecal Dotarizine and Nimodipine Treatments in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study in Rabbits. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_11

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  • DOI: https://doi.org/10.1007/978-3-7091-0356-2_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0355-5

  • Online ISBN: 978-3-7091-0356-2

  • eBook Packages: MedicineMedicine (R0)

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