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Evolution of Lipopolysaccharide Biosynthesis Genes

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Bacterial Lipopolysaccharides

Abstract

Lipopolysaccharide (LPS) is a highly polymorphic structure that differs within and between genera, and contains three main components: lipid A, core oligosaccharide (OS), and O-specific antigen in the order in which they occur in LPS, which correlates with increasing structural diversity for each component. In Escherichia coli, for example, there are five core OS types known and over 180 O-antigen forms (including Shigella), and in Salmonella enterica, 2 and 46 respectively. The diversity of O-antigen forms has been widely studied for some species although the forms known may be underestimates as most of the isolates typed are from humans or domestic animals and their associated environments.

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  1. Division of Microbiology, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, 2006, Australia

    Monica M. Cunneen & Peter R. Reeves

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  2. Peter R. Reeves
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Correspondence to Peter R. Reeves .

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  1. N.D. Zelinsky Institute of Organic Chemi, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, V-334, 119991, Russian Federation

    Yuriy A. Knirel

  2. Centre for Human Immunology and, Department of Microbiology and Immunolog, University of Western Ontario, London, N6A 5C1, Ontario, Canada

    Miguel A. Valvano

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Cunneen, M.M., Reeves, P.R. (2011). Evolution of Lipopolysaccharide Biosynthesis Genes. In: Knirel, Y., Valvano, M. (eds) Bacterial Lipopolysaccharides. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0733-1_11

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