Summary
Mammalian erythrocytes are known to have 4 distinct amino acid transport systems. The C system is found in sheep erythrocytes and is specific for neutral amino acids of intermediate size. Human cells lack the C system and have two alternative neutral amino acid transport mechanisms: the L system which is selective for large hydrophobic amino acids and a Na-dependent alanine-cysteine system. The L system is absent from ruminant and cat erythrocytes. Human, rabbit and cat cells, but not sheep erythrocytes, have a specific dibasic amino acid transport mechanism (Ly system). L-Tryptophan uptake by human erythrocytes is mediated by two routes: a saturable high-affinity transport mechanism selective for L-tryptophan and a low affinity uptake mediated by the L system. The saturable component of L-tryptophan transport occurs by a previously unidentified uptake system, and is the major route for L-tryptophan uptake at physiological substrate concentrations. This system is absent from sheep and cat erythrocytes.
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© 1979 Springer-Verlag Wien
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Young, J.D., Ellory, J.C. (1979). Transport of Tryptophan and Other Amino Acids by Mammalian Erythrocytes. In: Baumann, P. (eds) Transport Mechanisms of Tryptophan in Blood Cells, Nerve Cells, and at the Blood-Brain Barrier. Journal of Neural Transmission, vol 15. Springer, Vienna. https://doi.org/10.1007/978-3-7091-2243-3_12
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DOI: https://doi.org/10.1007/978-3-7091-2243-3_12
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