Summary
One of the major side effects of the methylxanthines and adenosine receptor antagonists caffeine and theophylline is the provocation of seizures. With the availability of highly selective adenosine receptor antagonists it was of interest to investigate if they would also induce seizures. In experiments with mice it was found that also highly selective adenosine receptor antagonists like Xanthine Amine congener are able to induce seizures. The therapeutic usefulness of highly selective adenosine receptor antagonists as e.g. cognitive enhancers in dementia syndromes is thus limited by this serious side effect.
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© 1990 Springer-Verlag Wien
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Deckert, J., Morgan, P.F., Jacobson, K.A., Daly, J.W., Marangos, P.J. (1990). Convulsant properties of methylxanthines, potential cognitive enhancers in dementia syndromes. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_33
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_33
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82197-8
Online ISBN: 978-3-7091-3396-5
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