Abstract
Rationale.Vagus nerve stimulation (VNS) by intermittent and programmed electrical stimulation of the left vagus nerve in the neck, has become widely available. It is an effective treatment for patients with refractory epilepsy. Patients can be provided with a magnet that allows to deliver additional stimulation trains. Since earlier studies have demonstrated the persistence of a stimulation effect after discontinuation of the stimulation train, we evaluated the clinical efficacy of VNS both in the programmed intermittent stimulation mode and magnet stimulation mode.
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References
Zanchetti A, Wang SC, Moruzzi G (1952) The effect of vagal afferent stimulation on the EEG pattern of the cat. Electroencephalog Clin Neurophysiol 4: 357–361
Zabara J (1992) Inhibition of experimental seizures in canines by repetitive stimulation. Epilepsia 33(6): 1005–1012
Woodbury DM, Woodbury JW (1990) Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia 31 [Suppl] 2: 7–19
Lockard JS, Congdon WC, DuCharme LL (1990) Feasibility and safety of vagal stimulation in monkey model. Epilepsia 31 [Suppl] 2: 20–26
Rutecki P (1990) Anatomical, pyhsiological and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 31 [Suppl] 2: S1—S6
Handforth A, DeGorgio CM, Schachter SCet al(1998) Vagus nerve stimulation therapy for partial onset seizures. A randomized, active control trial. Neurology 51: 48–55
Ben-Menachem E, Manon-Espaillat R, Ristanovic Ret al(1994) Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures. Epilepsia 35: 616–626
Ramsay RE, Uthman BM, Augustinsson LEet al(1994) Vagus nerve stimulation for treatment of partial seizures: 2. Safety, side-effects and tolerability. Epilepsia 35: 627–636
George R, Sonnen A, Upton Aet al(1995) The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology 45: 224–230
Morris GL, Mueller WM and the vagus nerve stimulation study group E01—E05 (1999) Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. Neurology 53(8): 1731–1735
Vonck K, Boon P, D’Havé M, Vandekerckhove T, O’Connor S, De Reuck J (1999) Long-term results of vagus nerve stimulation in refractory epilepsy. Seizure 8: 328–334
Reese T, Brent T, Zabara J (1990) An implantable neurocybernetic prosthesis system. Epilepsia 31 [Suppl] 2: S33—S37
Landy HJ, Ramsay RE, Slater J, Casiano RR, Morgan R (1993) Vagus nerve stimulation for complex partial seizures: surgical technique, safety and efficacy. J Neurosurg 78: 26–31
Lockard JS, Congdon WC, DuCharme LL (1990) Feasability and safety of vagal stimulation: the monkey model. Epilepsia 3 [Suppl] 2: S20–26
Takaya M, Terry WJ, Naritoku DK (1996) Vagus nerve stimulation induces a sustained anticonvulsant effect. Epilepsia 37: 1111–1116
McLaghlan RS (1993) Suppression of interictal spikes and seizures by stimulation of the vagus nerve. Epilepsia 34(5): 918–923
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© 2002 Springer-Verlag Wien
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Boon, P., Vonck, K., Van Walleghem, P., D’Havé, M., Caemaert, J., De Reuck, J. (2002). Vagus Nerve Stimulation for Epilepsy, Clinical Efficacy of Programmed and Magnet Stimulation. In: von Wild, K.R.H. (eds) Functional Rehabilitation in Neurosurgery and Neurotraumatology. Acta Neurochirurgica Supplements, vol 79. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6105-0_21
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DOI: https://doi.org/10.1007/978-3-7091-6105-0_21
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