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Opiates, Opioids and Their Receptors in the Modulation of Pain

  • Conference paper
Pain

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 38))

Abstract

The enormous growth of opioid research in the last decade was initiated by the identification of opiate receptors and the detection of their endogenous ligands, the opioid peptides or endorphins. A variety of different types of opioid receptors can now be distinguished and a considerable number of different opioid peptides have been identified. One of the questions arising from this development concerns the relationship between the multiplicity of opioid receptors and ligands, including that of the functions related to the various ligand-receptor interactions. In this context their role in the modulation of pain is of particular interest and will be discussed here.

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References

  1. Civelli O, Douglass J, Herbert E (1984) Pro-opiomelanocortin: a polyprotein at the interface of the endocrine and nervous systems. In: Udenfriend S, Meienhofer J (eds) The peptides— analysis, synthesis, biology, vol 6. Academic Press, Inc, London, pp 69 - 94

    Google Scholar 

  2. Czionkowski A, Costa T, Przewlocki R, Pasi A, Herz A (1983) Opiate receptor binding sites in human spinal cord. Brain Res 267: 392 - 396

    Article  Google Scholar 

  3. Faccini E, Uzumaki M, Gavoni S, Missale C, Spano PF, Covelli V, Trabucci M (1984) Afferent fibers mediate the increase of met- enkephalin elicited in the rat spinal cord by localized pain. Pain 18: 25 - 31

    Article  PubMed  CAS  Google Scholar 

  4. Fricker LD (1985) Neuropeptide biosysnthesis: focus on carboxy-peptidase processing enzymes. Trends Neurosci: 210— 214

    Article  Google Scholar 

  5. Goldstein A (1984) Biology and chemistry of the dynorphin peptides. In: Udenfriend S, Meienhofer J (eds) The peptides— analyses, synthesis, biology, vol 6. Academic Press, Inc, London, pp 96 - 146

    Google Scholar 

  6. Herz A (1984 a) Die Rolle multipler Opioid-Rezeptoren und ihrer Liganden bei der Schmerzmodulation. Arzneim- Forsch/Drug Res 34: 1080-1083

    Google Scholar 

  7. Herz A (1984b) Multiple opioid receptors. In: Delitala G et al (eds) Opioid modulation of endocrine function. Raven Press, New York, pp 11 - 19

    Google Scholar 

  8. Herz A (1984) Multiple endorphins as natural ligands of multiple opioid receptors. In: Müller EE, Genazzani AR (eds) Central and peripheral endorphins: basic and clinical aspects. Raven Press, New York, pp 43 - 52

    Google Scholar 

  9. Höllt V (1983) Multiple endogenous opioid peptides. TINS 6: 24 - 26

    Google Scholar 

  10. Höllt V, Sanchez-Blasquez P, Garzón J (1985) Multiple opioid ligands and receptors in the control of nociception. Phil Trans R Soc Lond B 308: 299 - 310

    Article  Google Scholar 

  11. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (1976) The effects of morphine and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197: 517 - 532

    PubMed  CAS  Google Scholar 

  12. Millan MH, Millan MJ, Herz A (1985) Midbrain-stimulation produced analgesia in the rat: characterization of the role of brain ß-endorphin. In: Fields HL, Dubner R, Cervero F (eds) Advances in pain research and therapy, vol 9. Raven Press, pp 493 - 498

    Google Scholar 

  13. Millan MJ, Millan MH, Pilcher CWT, Czionkowski A, Herz A, Colpaert C (1985) Spinal cord dynorphin may modulate noci¬ception via a K-opioid receptor in chronic arthritic rats. Brain Res, 340: 156 - 159

    Article  PubMed  CAS  Google Scholar 

  14. Mucha R, Herz A (1985) Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology 86: 274 - 280

    Article  PubMed  CAS  Google Scholar 

  15. Numa S (1984) Opioid peptide precursors and their genes. In: Udenfriend S, Meienhofer J (eds) The peptides—analysis, syn¬thesis, biology, vol 6. Academic Press, Inc, London, pp 1 - 23

    Google Scholar 

  16. Paterson SJ, Robson LE, Kosterlitz HW (1984) Opioid re-ceptors. In: Udenfriend S, Meienhofer J (eds) The peptides— analysis, synthesis, biology, vol 6. Academic Press, Inc, London pp 147 - 190

    Google Scholar 

  17. Pfeiffer A, Brantl V, Herz A, Emrich H (1986) Psycholomimesis mediated by K-opiate receptous. Science 233: 774 - 776

    Article  PubMed  CAS  Google Scholar 

  18. Przewlocki R, Gramsch C, Pasi A, Herz A (1983) Characteriza¬tion and localization of immunoreactive dynorphin, a-neo- endorphin, met-enkephalin and Substance P in human spinal cord. Brain Res 280: 95 - 103

    Article  PubMed  CAS  Google Scholar 

  19. Schmauss C, Yaksh T (1984) In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral, chemical and cutaneous thermal stimuli in the rat. J Pharmacol Exp Ther 228: 1-12

    Google Scholar 

  20. Schulz R, Wüster M, Herz A (1984) Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques. J Pharmacol Exp Ther 230: 200 - 204

    PubMed  CAS  Google Scholar 

  21. Seizinger BR, Höllt V, Herz A (1984 a) Proenkephalin B (prodynorphin)-derived opioid peptides: evidence for a dif-ferential processing in lobes of the pituitary. Endocrinology 115: 662 - 671

    Google Scholar 

  22. Seizinger BR, Grimm C, Höllt V, Herz A (1984 b) Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary. J Neurochem 42: 447 - 457

    Article  PubMed  CAS  Google Scholar 

  23. Turner AJ (1984) Neuropeptide processing enzymes. Trends Neurosci: 258 - 260

    Google Scholar 

  24. Udenfriend S, Kilpatrick DL (1984) Proenkephalin and the products of its processing: chemistry and biology. In: Uden-friend S, Meienhofer J (eds) The Peptides. Academic Press, Inc, London, pp 25 - 68

    Google Scholar 

  25. Watson SJ, Akil H, Khaehatutrian H, Young E, Lewis ME (1984) Opioid systems: anatomical, physiological and clinical perspectives. In: Hughes J, Collier HOJ, Ranee MJ, Tyers MB (eds) The Peptides. Taylor & Francis, London and Philadelphia, pp 145 - 178

    Google Scholar 

  26. Wood PL (1982) Multiple opiate receptors: support for unique mu, delta and kappa sites. Neuropharmacology 21: 287 - 297

    Article  Google Scholar 

  27. Yaksh TL, Noueihed R (1985) The physiology and pharma-cology of spinal opiates. Ann Rev Pharmacol Toxicol 25: 433- 462

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18 a, D-8033, Planegg-Martinsried, Federal Republic of Germany

    Prof. Dr. Albert Herz

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  1. Prof. Dr. Albert Herz
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Editor information

Editors and Affiliations

  1. Clinique Neurochirurgicale, Bruxelles, Belgium

    Jean Brihaye

  2. Neurochirurgische Universitätsklinik, Homburg/Saar, Federal Republic of Germany

    Fritz Loew

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© 1987 Springer-Verlag

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Herz, A. (1987). Opiates, Opioids and Their Receptors in the Modulation of Pain. In: Brihaye, J., Loew, F., Pia, H.W. (eds) Pain. Acta Neurochirurgica Supplementum, vol 38. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6975-9_5

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  • DOI: https://doi.org/10.1007/978-3-7091-6975-9_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7457-9

  • Online ISBN: 978-3-7091-6975-9

  • eBook Packages: Springer Book Archive

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