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Matrix metalloproteinases in airways inflammation of asthma and chronic obstructive pulmonary disease

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Matrix Metalloproteinases in Tissue Remodelling and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Matrix metalloproteinases (MMPs) are produced in the respiratory tract from different inflammatory and structural cells and are involved in wound healing, inflammatory cell trafficking and tissue remodelling and repair. MMPs are tightly regulated and their effects are counterbalanced by their physiological inhibitors, tissue inhibitors of MMPs (TIMPs). Increased secretion and expression of MMPs have been reported in asthma and chronic obstructive pulmonary disease (COPD), which are chronic inflammatory lung diseases that lead to chronic airflow obstruction associated with significant mortality and morbidity. Cytokines and growth factors which are involved in these inflammatory processes interact directly with MMPs, leading to a regulation of their expression or changes in their biological activities through enzymatic cleavage. Different MMPs play a specific role with variations in different lung diseases. In COPD, MMP 1, MMP 9 and MMP 12 from lung macrophages play an important role in degradation of matrix leading to emphysema. MMPs may represent relevant therapeutic targets for many diseases. However, their contribution is potentially complex since MMPs may have both beneficial as well as deleterious effects. Thus, some actions may lead to pro-inflammatory effects, while others may also cause anti-inflammatory effects. Therefore, the precise role of these MMPs in airways disease with airflow obstruction need to be clarified carefully before selective MMP inhibitors are tried for therapeutic aims in these diseases.

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Leung, SY., Chung, K.F. (2008). Matrix metalloproteinases in airways inflammation of asthma and chronic obstructive pulmonary disease. In: Lagente, V., Boichot, E. (eds) Matrix Metalloproteinases in Tissue Remodelling and Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8585-9_2

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