Abstract
Interleukin-17 (IL-17) plays a major role in various models of immune-mediated tissue injury, including organ-specific autoimmunity, allergic disorders and microbial infections. Th17 cells are currently the most thoroughly characterized source of IL-17 credited for causing and sustaining the tissue damage mediated by this cytokine. Similarly to their Th1 and Th2 counterpart, Th17 cells depend on specific factors for their differentiation from naïve T cell precursors, before acquiring their typical cytokine profile. However, this is not the case for all IL-17-producing cells, particularly for a subset of invariant natural killer T cells, termed iNKT17, which are ready to produce this cytokine immediately upon stimulation, in keeping with their capacity to intervene during early stages of the inflammatory response.
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Miche, ML., Leite-de-Moraes, M.C. (2009). Other sources of IL-17: Invariant natural killer T cells. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_3
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DOI: https://doi.org/10.1007/978-3-7643-8681-8_3
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