Skip to main content

Genetics of schizophrenia and the impact of neuropsychology

  • Conference paper
Search for the Causes of Schizophrenia
  • 307 Accesses

Abstract

As evidenced by a bulk 0of twin and family studies schizophrenia is clearly a genetically influenced disorder, with more than 50% of the etiological variance being due to genetic variation. This genetic diathesis has to be considered together with the preferential onset of the disorder in late adolescence and early adulthood, and the severe associated disability and impairment. On this basis a decline of prevalence over time in all populations has been proposed but not observed; this constellation is called the “paradox of schizophrenia”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405–411

    Article  PubMed  CAS  Google Scholar 

  • Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M (2000) The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 67:369–382

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ (1995) A Darwinian approach to the origins of psychosis. Br J Psychiatry 167:12–25

    Article  PubMed  CAS  Google Scholar 

  • DeLisi LE, Craddock NJ, Detera-Wadleigh S, Foroud T, Gejman P, Kennedy JL, Lendon C, Macciardi F, McKeon P, Mynett-Johnson L, Nurnberger JI jr, Paterson A, Schwab S, Van Broeckhoven C, Wildenauer D, Crow TJ (2000) Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14–18, 1999. Am J Med Genet 96:434–449

    Article  PubMed  CAS  Google Scholar 

  • Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Va1108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917–6922

    Article  PubMed  CAS  Google Scholar 

  • Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269

    Article  PubMed  CAS  Google Scholar 

  • Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT (1995) Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 104:286–304

    Article  PubMed  CAS  Google Scholar 

  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645

    Article  PubMed  Google Scholar 

  • Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361:417–419

    Article  PubMed  CAS  Google Scholar 

  • Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (2003) Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72:1131–1140

    Article  PubMed  CAS  Google Scholar 

  • Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12:426–445

    Article  PubMed  CAS  Google Scholar 

  • Levinson DF, Holmans P, Straub RE, Owen MJ, Wildenauer DB, Gejman PV, Pulver AE, Laurent C, Kendler KS, Walsh D, Norton N, Williams NM, Schwab SG, Lerer B, Mowry BJ, Sanders AR, Antonarakis SE, Blouin JL, DeLeuze JF, Mallet J (2000) Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 67:652–663

    Article  PubMed  CAS  Google Scholar 

  • Tsuang MT, Stone WS, Tarbox SI, Faraone SV (2002) An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention. Schizophr Res 54:169–175

    Article  PubMed  Google Scholar 

  • Wagner M, Frommann I, Schröder C, Matuschek E, Pukrop R (2002) Neurocognitive performance in presumed prodromal stages of schizophrenia. Schizophr Res 53 (Suppl 3):35–36

    Google Scholar 

  • Wexler BE, Donegan N, Stevens AA, Jacob SA (2002) Deficits in language-mediated mental operations in patients with schizophrenia. Schizophr Res 53:171–179

    Article  PubMed  Google Scholar 

  • Wright AF, Carothers AD, Pirastu M (1999) Population choice in mapping genes for complex diseases. Nat Genet 23:397–404

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Maier, W., Wagner, M., Falkai, P., Schwab, S.G. (2004). Genetics of schizophrenia and the impact of neuropsychology. In: Gattaz, W.F., Häfner, H. (eds) Search for the Causes of Schizophrenia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1953-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-7985-1953-4_18

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62331-8

  • Online ISBN: 978-3-7985-1953-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics