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Epithelial Organization of Adult Neurogenic Germinal Niches

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Neurogenesis in the Adult Brain I

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Abstract

The adult mammalian brain is perhaps the most complex biological system under scientific study. Yet for all of its complexity, the brain develops from a simple epithelium. Throughout development, most neurons and macroglia are derived from embryonic neural stem cells that remain part of this neuroepithelium lining the brain ventricles. However, it is thought that neural stem cells in the adult brain, which are displaced to the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampus, may have lost their epithelial properties. This chapter explores the epithelial organization of cells lining the ventricles in the adult rodent brain and reveals that a mixed neuroepithelium persists in the adult that contains neural stem cells in addition to differentiated, non-dividing ependymal cells.

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Acknowledgements

This work was supported by the National Institutes of Health (NIH) grants HD-32116 and NS28478, the Sandler Family Supporting Foundation, and the John G. Bowes Research Fund. A.A.-B. holds the Heather and Melanie Muss Endowed Chair. We thank Kenneth Xavier Probst of Xavier Studio for assisting with the design and preparation of Figs. 12.3 and 12.5.

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Authors and Affiliations

  1. Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, 94143, USA

    Zaman Mirzadeh, Young-Goo Han & Arturo Alvarez-Buylla

  2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, Room HSW-1201, 0525, San Francisco, CA, 94143-0525, USA

    Zaman Mirzadeh, Young-Goo Han & Arturo Alvarez-Buylla

  3. Laboratorio de Morfología Celular, Centro de Investigación Príncipe Felipe, Valencia, Spain

    José Manuel García-Verdugo

  4. CIBERNED, Madrid, Spain

    José Manuel García-Verdugo

Authors
  1. Zaman Mirzadeh
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  2. Young-Goo Han
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  3. José Manuel García-Verdugo
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  4. Arturo Alvarez-Buylla
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Corresponding author

Correspondence to Arturo Alvarez-Buylla .

Editor information

Editors and Affiliations

  1. Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan

    Tatsunori Seki Ph.D. (Professor) (Professor)

  2. Department of Developmental and Regenerative Biology, Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Kazunobu Sawamoto Ph.D. (Professor) (Professor)

  3. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent M.D. (Associate Professor) & Arturo Alvarez-Buylla Ph.D. (Professor) (Associate Professor) &  (Professor)

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© 2011 Springer

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Mirzadeh, Z., Han, YG., García-Verdugo, J.M., Alvarez-Buylla, A. (2011). Epithelial Organization of Adult Neurogenic Germinal Niches. In: Seki, T., Sawamoto, K., Parent, J.M., Alvarez-Buylla, A. (eds) Neurogenesis in the Adult Brain I. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53933-9_12

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