Abstract
Wound healing in anastomosed intestine, sutured muscle layer and skin layer was examined as related to the redistribution of zinc during total parenteral nutrition(TPN). Gr.I(normally fed rats) and Gr.II(protein-malnourished rats) received TPN with zinc(Gr.Ia,IIa) or without zinc(Gr.Ib,IIb) for 6 days postoperatively. As a result, there was no significant difference between Gr.Ia and Ib in bursting pressure of intestinal anastomosis, tensile strength(TS) of muscle wound and skin wound, collagen-hydroxyproline (HYP) in each wound and zinc concentration in each tissue, whereas, the reduction of TS and HYP in skin wound was marked in Gr.IIb compared to Gr.IIa accompanied with the decrease of skin zinc concentration. In conclusion, redistribution of zinc was manifested in protein-malnourished rats during TPN and it might affect wound healing.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Reference
Adamsons RJ, Musco F, Enquist IF (1966) The chemical dimensions of a healing incision. Surg Gynecol Obstet 123: 515–521
Crawford DT, Bains JW, Ketcham AS (1965) A standard model for tensiometric studies. J Surg Res 6: 265–269
Kay RG, Tasman-Jones C (1975) Acute zinc deficiency in man during intravenous alimentation. Aus NZ J Surg 45: 325–330
Kivirikko KI, Laitinen O, Prockop DJ (1967) Modification of a specific assay for hydroxyproline in urine. Anal Biochem 19: 249–255
Nezu R, Takagi Y, Okada A, Inoue Y, Miyata M, Kawashima Y (1988) Effect of total parenteral nutrition on distribution of zinc in murine tissues. Trace Nutrients Research 4: 115–120
O’Dell BL (1974) Role of zinc in protein synthesis. In: Pories WJ (ed) Clinical application of zinc metabolism. Charles C Thomas, Springfield, p5–8
Okada A, Takagi Y, Itakura T, Satani M, Manabe T, Iida Y, Nose O, Iwasaki M, Kasahara N (1975) Zinc deficiency during intravenous hyperalimentation. Igaku-no-Ayumi(Advan.Med.) 92: 436–442
Parker MM, Humoller FL, Mahler DJ (1967) Determination of copper and zinc in biological materials. Clin Chem 13: 40–48
Steiger E, Vars HM, Dudrick SJ (1972) A technique for long-term intravenous feeding in unrestrained rats. Arch Surg 104: 330–332
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Tokyo
About this paper
Cite this paper
Nezu, R., Takagi, Y., Okada, A., Kawashima, Y. (1990). Effect of Zinc Redistribution on Wound Healing during Total Parenteral Nutrition in Rats. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_28
Download citation
DOI: https://doi.org/10.1007/978-4-431-68120-5_28
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68122-9
Online ISBN: 978-4-431-68120-5
eBook Packages: Springer Book Archive