Evaluation of Preoperative Serum CEA and IAP Levels in the Patients with Colorectal Cancer

Abstract

The usefulness of the preoerative measurement of serum CEA and IAP level as prognostic factors in colorectal cancer patients was investigated. The cases were divided into negative or positive groups acording to cut off points of CEA of 5ng/ml, IAP of 500μg/ml orIAP of 580μg/ml respectivly. In comparison of survival rates in colon cancer, the groups of CEA negative, IAP500 negative or IAP580 negative were all significantly better than those of positive ones respectivly. But in rectal cancer, only the rate of IAP580 negative one was significantly better than that of positive one. To further investigation of above results, according to the general rules for clinical and pathological studies on cancer of colon, rectum and anus in Japan, distributions of cases by histological backgrounds and by these cut off points were analized. Results were those both in colon and rectal cancer, CEA correlated almost all bacgrounds except histological type and lymphnode metastasis. But IAP500 correlated only operative curability in rectal cancer, and also IAP580 corelated only operative culability in both colon and rectal cancer and lymphnode metastasis in colon cancer.