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SN1 Catalyzes Transport of Glutamine Across Müller Cells in Retina

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The Neural Basis of Early Vision

Part of the book series: Keio University International Symposia for Life Sciences and Medicine ((KEIO,volume 11))

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Abstract

High-affinity glutamate (Glu) transporters localized on Müller cell membranes transport synaptically released Glu into these cells from the extracellular side. Müller cells, similar to most glial cells in the nervous system, generate glutamine (Gln) from Glu using the enzyme glutamine synthetase. Although it has been postulated that Gln is transported from these Müller cells to replenish synaptic Glu, little is known about the identity or properties of the Gln transporter. We investigated the Gln transport mechanism in Müller cells dissociated from retinae of tiger salamander (Ambystoma tigrinum) using three different approaches: intracellular pH (pHi) measurements, whole-cell voltage-clamp, and immunocytochemistry.

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Reference

  1. Chaudhry FA, Reimer RJ, Krizaj D, et al. (1999) Molecular analysis of System N suggests novel physiological roles in nitrogen metabolism and synaptic transmission, Cell 99: 769–780

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Authors and Affiliations

  1. Division of Biological Sciences, Faculty of Human Environmental Studies, Hiroshima Shudo University, 1-1-1 Otsuka-higashi, Asaminami-ku, Hiroshima, 731-3195, Japan

    Kyoh-Ichi Takahashi

  2. Departments of Ophthalmology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143-0730, USA

    Kyoh-Ichi Takahashi, David Krizaj & David R. Copenhagen

Authors
  1. Kyoh-Ichi Takahashi
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  2. David Krizaj
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  3. David R. Copenhagen
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Editor information

Editors and Affiliations

  1. Department of Physiology School of Medicine, Keio University, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan

    Akimichi Kaneko M.D., Ph.D. (Professor) (Professor)

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© 2003 Springer-Verlag Tokyo

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Takahashi, KI., Krizaj, D., Copenhagen, D.R. (2003). SN1 Catalyzes Transport of Glutamine Across Müller Cells in Retina. In: Kaneko, A. (eds) The Neural Basis of Early Vision. Keio University International Symposia for Life Sciences and Medicine, vol 11. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68447-3_12

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  • DOI: https://doi.org/10.1007/978-4-431-68447-3_12

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68449-7

  • Online ISBN: 978-4-431-68447-3

  • eBook Packages: Springer Book Archive

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