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Mechanisms of Fibrinolysis-Associated Hemorrhagic Transformation

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Thrombolytic Therapy in Acute Ischemic Stroke III

Abstract

Symptomatic intracerebral hemorrhage is an often-feared companion of acute cerebral ischemia treated with plasminogen activators. The pathophysiology of parenchymal hemorrhage is poorly understood and has been the subject of previous treatises in this series [1,2]. Clinical studies of this disorder suggest a spectrum of clinical severity from asymptomatic episodes diagnosed by computed tomographic (CT) scan or magnetic resonance imaging (MRI) to catastrophic events with debilitating or fatal issue [3–13]. The importance of understanding the pathogenesis of hemorrhagic events, particularly in the setting of fibrinolytic intervention, is emphasized by the dilemma that can arise in judging whether a particular hemorrhage may be reasonably attributable to the plasminogen activator the patient has received.

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Author information

Authors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    G. J. del Zoppo, Y. Okada, G. F. Hamann & R. Fitridge

  2. Department of Neurology, Tufts-New England Medical Center, 171 Harrison Avenue, Boston, MA, 02111, USA

    M. S. Pessin

Authors
  1. G. J. del Zoppo
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  2. Y. Okada
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  3. G. F. Hamann
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  4. R. Fitridge
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  5. M. S. Pessin
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Editor information

Editors and Affiliations

  1. Cerebrovascular Division, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565, Japan

    Takenori Yamaguchi M.D., D.M.Sc.  & Kazuo Minematsu M.D., D.M.Sc.  & 

  2. Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ku, Himeji, Hyogo, 670, Japan

    Etsuro Mori M.D.

  3. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Gregory J. del Zoppo M.D.

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© 1995 Springer-Verlag Tokyo

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del Zoppo, G.J., Okada, Y., Hamann, G.F., Fitridge, R., Pessin, M.S. (1995). Mechanisms of Fibrinolysis-Associated Hemorrhagic Transformation. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_30

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  • DOI: https://doi.org/10.1007/978-4-431-68459-6_30

  • Publisher Name: Springer, Tokyo

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  • Online ISBN: 978-4-431-68459-6

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