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Mechanisms of Mucus Induction in Asthma

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Allergy Frontiers: Clinical Manifestations

Part of the book series: Allergy Frontiers ((ALLERGY,volume 3))

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Abstract

Mucus hypersecretion is a defining feature of asthma and contributes significantly to airway obstruction. The mechanisms by which a normal airway epithelium is converted to a mucus-producing epithelium in asthma are complex. Inflammation in asthma promotes metaplasia of ciliated and Clara cells into goblet cells after both EGFR activation and the effects of IL-13 on Stat6 activation. Recently identified transcription factors and proteins highlight critical steps in the pathway that leads to the transition to a mucus-secreting airway epithelium.

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Authors and Affiliations

  1. Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, 208057, New Haven, CT 06520, USA

    Lauren Cohn

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  1. Lauren Cohn
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  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Cohn, L. (2009). Mechanisms of Mucus Induction in Asthma. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Clinical Manifestations. Allergy Frontiers, vol 3. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88317-3_11

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