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Lumbar Degenerative Disc Disease

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Diseases of the Brain, Head & Neck, Spine

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Abstract

The sequelae of disc degeneration remain among the leading causes of functional incapacity in both men and women and are a common source of chronic disability in the working years. A significant portion of the cost of the morbidity associated with neck and back disorders is related to diagnostic testing, mostly medical imaging, the results of which may rightly or wrongly provide the basis for subsequent, more invasive treatments.

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References

  1. Hestbaek L, Iachine IA, Leboeuf-Yde C et al (2004) Heredity of low back pain in a young population: a classical twin study. Twin Res 7:16–26

    Article  PubMed  Google Scholar 

  2. Marini JC (2001) Genetic risk factors for lumbar disk disease. JAMA 285:1886–1888

    Article  PubMed  CAS  Google Scholar 

  3. Modic M (2007) Degenerative disc disease: genotyping, MR imaging and phenotyping. Skeletal Radiol 36:91–93

    Article  PubMed  Google Scholar 

  4. Annunen S, Paassilta P, Lohiniva J et al (1999) An allele of COL9A2 associated with intervertebral disc disease. Science 285:409–412

    Article  PubMed  CAS  Google Scholar 

  5. Nelson CL, Janecki CJ, Gildenberg PL, Sava G (1972) Disk protrusions in the young. Clin Orthop Relat Res 88:142–150

    Article  PubMed  CAS  Google Scholar 

  6. Varlotta GP, Brown MD, Kelsey JL, Golden AL (1991) Familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old. J Bone Joint Surg Am 73:124–128

    PubMed  CAS  Google Scholar 

  7. Matsui H, Terahata N, Tsuji H et al (1992) Familial predisposition and clustering for juvenile lumbar disc herniation. Spine 17:1323–1328

    PubMed  CAS  Google Scholar 

  8. Scapinelli R (1993) Lumbar disc herniation in eight siblings with a positive family history for disc disease. Acta Orthop Belg 59:371–376

    PubMed  CAS  Google Scholar 

  9. Quinet RJ, Hadler NM (1979) Diagnosis and treatment of backache. Semin Arthritis Rheum 8:261–287

    Article  PubMed  CAS  Google Scholar 

  10. Bonneville JF, Dietemann JL (1992) Imaging in sciatica. Rev Prat 42:554–566

    PubMed  CAS  Google Scholar 

  11. Brant-Zawadzki MN, Jensen MC, Obuchowski N, Ross JS, Modic MT (1995) Interobserver and intraobserver variability in interpretation of lumbar disc abnormalities. A comparison of two nomenclatures. Spine 20:1257–1263

    Article  PubMed  CAS  Google Scholar 

  12. Breton G (1991) Is that a bulging disk, a small herniation or a moderate protrusion? Can Assoc Radiol J 42:318

    PubMed  CAS  Google Scholar 

  13. Fardon DF, Balderston RA, Garfin SR et al (1991) Disorders of the spine, a coding system for diagnoses. Hanley and Belfus, Philadelphia, pp 20–22

    Google Scholar 

  14. Milette PC (2001) Reporting lumbar disk abnormalities: at last, consensus! AJNR Am J Neuroradiol 22:428–429

    PubMed  CAS  Google Scholar 

  15. Czervionke LF (1993) Lumbar intervertebral disc disease. Neuroimaging Clin N Am 3:465–485

    Google Scholar 

  16. Modic MT, Herfkens RJ (1990) Intervertebral disk: normal age-related changes in MR signal intensity. Radiology 177:332–333

    PubMed  CAS  Google Scholar 

  17. Sether LA, Yu S, Haughton VM, Fischer ME (1990) Intervertebral disk: normal age-related changes in MR signal intensity. Radiology 177:385–388

    PubMed  CAS  Google Scholar 

  18. Yu S, Haughton VM, Sether LA et al (1989) Criteria for classifying normal and degenerated lumbar intervertebral disks. Radiology 170:523–526

    PubMed  CAS  Google Scholar 

  19. Friberg S, Hirsch C (1949) Anatomical and clinical studies on lumbar disc degeneration. Acta Orthop Scand 19:222–242

    PubMed  CAS  Google Scholar 

  20. Modic MT, Pavlicek W, Weinstein MA et al (1984) Magnetic resonance imaging of intervertebral disk disease. Clinical and pulse sequence considerations. Radiology 152:103–111

    PubMed  CAS  Google Scholar 

  21. Majors AW, McDevitt CA, Silgalis I, Modic MT (1994) A correlative analysis of T2, ADC and MT radio with water, hydroxyproline and GAG content in excised human intervertebral disk. Orthopedic Research Society, New Orleans, pp 116–120

    Google Scholar 

  22. Hirsch C (1959) Studies on the pathology of low back pain. J Bone Joint Surg Br 41-B:237–243

    PubMed  CAS  Google Scholar 

  23. Coventry MB (1969) Anatomy of the intervertebral disk. Clin Orthop Relat Res 67:9–15B

    Article  PubMed  CAS  Google Scholar 

  24. Knutsson F (1942) The vacuum phenomenon in the intervertebral discs. Acta Radiol 23:173–179

    Article  Google Scholar 

  25. Bangert BA, Modic MT, Ross JS et al (1995) Hyperintense disks on T1-weighted MR images: correlation with calcification. Radiology 195:437–443

    PubMed  CAS  Google Scholar 

  26. de Roos A, Kressel H, Spritzer C, Dalinka M (1987) MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. AJR Am J Roentgenol 149:531–534

    PubMed  Google Scholar 

  27. Masaryk TJ, Boumphrey F, Modic MT et al (1986) Effects of chemonucleolysis demonstrated by MR imaging. J Comput Assist Tomogr 10:917–923

    Article  PubMed  CAS  Google Scholar 

  28. Modic MT, Steinberg PM, Ross JS et al (1988) Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 166:193–199

    PubMed  CAS  Google Scholar 

  29. Modic MT (2007) Modic type 1 and type 2 changes (editorial). J Neurosurg Spine 6:150–151

    Article  PubMed  Google Scholar 

  30. Harris RI, Macnab I (1954) Structural changes in the lumbar intervertebral discs; their relationship to low back pain and sciatica. J Bone Joint Surg Br 36-B:304–322

    PubMed  CAS  Google Scholar 

  31. Schellinger D, Wener L, Ragsdale BD, Patronas NJ (1987) Facet joint disorders and their role in the production of back pain and sciatica. Radiographics 7:923–944

    PubMed  CAS  Google Scholar 

  32. Arnoldi CC, Brodsky AE, Cauchoix J et al (1976) Lumbar spinal stenosis and nerve root entrapment syndromes. Definition and classification. Clin Orthop Relat Res 115:4–5

    PubMed  Google Scholar 

  33. Amundsen T, Weber H, Lilleas F et al (1995) Lumbar spinal stenosis. Clinical and radiologic features. Spine 20:1178–1186

    Article  PubMed  CAS  Google Scholar 

  34. ECRI (2001) Treatment of degenerative lumbar spinal stenosis. Volume 1: Evidence report. AHRQ Publication No. 01-E048 32

    Google Scholar 

  35. Borenstein DG, O’Mara JW Jr., Boden SD et al (2001) The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects: a seven-year follow-up study. J Bone Joint Surg Am 83-A:1306–1311

    PubMed  CAS  Google Scholar 

  36. Mixter W, Barr JS (1934) Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 211:210–214

    Google Scholar 

  37. Freemont AJ, Peacock TE, Goupille P et al (1997) Nerve in-growth into diseased intervertebral disc in chronic back pain. Lancet 350:178–181

    Article  PubMed  CAS  Google Scholar 

  38. Von Korff M, Saunders K (1996) The course of back pain in primary care. Spine 21:2833–2837

    Article  Google Scholar 

  39. Crock HV (1986) The presidential address: ISSLS, internal disc disruption, a challenge to disc prolapse fifty years on. Spine 11:650–653

    Article  PubMed  CAS  Google Scholar 

  40. Marshall LL, Trethewie ER, Curtain CC (1977) Chemical radiculitis. A clinical, physiological and immunological study. Clin Orthop Relat Res 129:61–67

    PubMed  Google Scholar 

  41. Lee G (2000) Systemic inflammatory response with plasma C-reactive protein elevation in disk-related lumbosciatic syndrome. Joint Bone Spine 67:452–455

    Google Scholar 

  42. Igarashi T, Kikuchi S, Shubayev V, Myers RR (2000) Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 25:2975–2980

    Article  PubMed  CAS  Google Scholar 

  43. Olmarker K, Rydevik B (2001) Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine 26:863–869

    Article  PubMed  CAS  Google Scholar 

  44. Genevay S, Stingelin S, Gabay C (2004) Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study. Ann Rheum Dis 63:1120–1123

    Article  PubMed  CAS  Google Scholar 

  45. Karppinen J, Korhonen T, Malmivaara A et al (2003) Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica. Spine 28:750–753

    Article  PubMed  Google Scholar 

  46. Korhonen T, Karppinen J, Malmivaara A et al (2004) Efficacy of infliximab for disc herniation-induced sciatica: one-year follow-up. Spine 29:2115–2119

    Article  PubMed  Google Scholar 

  47. Sox H, Stern S, Owens D, Abrams HL (1989) Assessment of diagnostic technology in health care. Rationale, methods, problems and directions. National Academy Press, Washington DC

    Google Scholar 

  48. Wiesel SW, Tsourmas N, Feffer HL et al (1984) A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine 9:549–551

    Article  PubMed  CAS  Google Scholar 

  49. Boden SD, Davis DO, Dina TS et al (1990) Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 72:403–408

    PubMed  CAS  Google Scholar 

  50. Jensen MC, Brant-Zawadzki MN, Obuchowski N et al (1994) Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med 331:69–73

    Article  PubMed  CAS  Google Scholar 

  51. Modic MT, Ross JS, Obuchowski NA et al (1995) Contrast-enhanced MR imaging in acute lumbar radiculopathy: a pilot study of the natural history. Radiology 195:429–435

    PubMed  CAS  Google Scholar 

  52. Modic MT, Obuchowski NA, Ross JS et al (2005) Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome. Radiology. 237:597–604

    Article  PubMed  Google Scholar 

  53. Vital JM, Gille O, Pointillart V et al (2003) Course of Modic 1 six months after lumbar posterior osteosynthesis. Spine 28:715–720

    Article  PubMed  CAS  Google Scholar 

  54. Braithwaite I, White J, Saifuddin A et al (1998) Vetebral endplate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J 7 363–368

    Article  PubMed  CAS  Google Scholar 

  55. Buttermann GR, Heithoff KB, Ogilvie JW et al (1997) Vertebral body MRI related to lumbar fusion results. Eur Spine J 6:115–120

    Article  PubMed  CAS  Google Scholar 

  56. White AA 3rd, Gordon SL (1982) Synopsis: workshop on idiopathic low-back pain. Spine 7:141–149

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Radiology, Lerner College of Medicine, Cleveland, OH, USA

    Michael T. Modic

  2. Department of Medical Imaging, Sunnybrook Healt Sciences Centre, Toronto, ON, Canada

    Sean Symons

Authors
  1. Michael T. Modic
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  2. Sean Symons
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Editor information

Editors and Affiliations

  1. Hospital Balgrist, Radiology, Orthopedic University, Zurich, Switzerland

    J. Hodler

  2. Nuclear Medicine, University Hospital, Zurich, Switzerland

    G. K. Von Schulthess

  3. Kilchberg/Zurich, Switzerland

    Ch. L. Zollikofer

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Modic, M.T., Symons, S. (2008). Lumbar Degenerative Disc Disease. In: Hodler, J., Von Schulthess, G.K., Zollikofer, C.L. (eds) Diseases of the Brain, Head & Neck, Spine. Springer, Milano. https://doi.org/10.1007/978-88-470-0840-3_28

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  • DOI: https://doi.org/10.1007/978-88-470-0840-3_28

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0839-7

  • Online ISBN: 978-88-470-0840-3

  • eBook Packages: MedicineMedicine (R0)

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