Riassunto
Nonostante i progressi nella biologia molecolare, nell’istochimica, nell’immunoistochimica, nella microscopia elettronica e nella radiologia, l’analisi anatomo-patologica di routine rimane l’elemento fondamentale per la diagnosi e la stadiazione dei tumori della testa e del collo. Questo capitolo intende descrivere la storia naturale dei carcinomi squamocellulari delle mucose (SCC) — l’archetipo dei tumori maligni della testa e del collo — sulla base di quello che si riconosce all’esame istologico di routine. Le possibili difficoltà con cui il patologo deve confrontarsi per fare diagnosi ai diversi stadi della storia naturale della malattia vengono illustrati in modo da aiutare i clinici ad apprezzare le procedure applicate nella diagnosi istologica dei tumori e le possibili cause di incertezza o controversia.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliografia
Califano J, van der Riet P, Westra W et al (1996) Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56:2488–2492
Barnes L, Eveson JW, Reichart P, Sidransky D (eds) (2005) World health organization Classification of Tumours. Pathology & Genetics. Head and Neck Tumours. IARC Press, Lyon
Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E (2008) Oral Epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med 37:127–133
Krutchkoff DJ, Eisenberg E (1985) Lichenoid dysplasia: a distinct histopathologic entity. Oral Surg Oral Med Oral Pathol 30:308–315
Woolgar JA, Triantafyllou A (2009) Pitfalls and procedures in the diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis. Oral Oncol 45:361–385
Daley TD, Lovas JG, Peters E et al (1996) Salivary gland duct involvement in oral epithelial dysplasia and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:186–192
Cabay RJ, Morton TH, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med 36:255–261
Odell EW, Morgan PR (1998) Biopsy Pathology of the Oral Tissues. Chapman and Hall, London
Allon D, Kaplan I, Manor R, Calderon S (2002) Carcinoma cuniculatum of the jaw: a rare variant of oral carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:601–608
O’charoenat P, Pillai G, Patel S (2003) Tumour thickness predicts cervical nodal metastasis and survival in early tongue cancer. aral Oncol 39:386–390
Odell EW, Jani P, Sherriff M et al (1994) The prognostic value of individual histologie grading parameters in small lingual squamous cell carcinomas. The importance of the pattern of invasion. Cancer 74:789–794
Bryne M, Koppang HS, Lilleng R, Kjaerheim A (1992) Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol 166:375–381
Mallofre C, Cardessa A, Campo E et al (1993) Expression of cytokeratins in squamous cell carcinomas of the larynx: immunohistochemical analysis and correlation with prognostic factors. Pathol Res Pract 189:275–282
Brandwein-Gensler M, Teixeira MS, Lewis CM (2005) Oral squamous cell carcinoma: histological risk assessment but not margin status is strongly predictive of local disease free and overall survival. Am J Surg Pathol 29:167–178
Rogers SN, Brown JS, Woolgar JA et al (2009) Survival following primary surgery for oral cancer. Oral Oncol 45:201–211
Woolgar JA, Scott J (1995) Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue/floor of mouth. Head Neck 17:463–472
Woolgar JA, Triantafyllou A (2005) A histopathological appraisal of surgical margins in oral and oropharyngeal cancer resection specimens. Oral Oncol 41:1034–1043
Shaw RJ, Brown JS, Woolgar JA et al (2004) The influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma. Head Neck 26:861–869
Furniss CS, McClean MD, Smith JF (2007) Human papillomavirus 16 and head and neck squamous cell carcinoma. Int J Cancer 120:2386–2392
Woolgar J, Triantafyllou A (2007) Neck dissections: A practical guide for the reporting histopathologist. Cur Diag Pathol 13:499–511
King RJB (2000). Cancer Biology, n2nd edn. Pearson Education, Harlow
Sobin L, Wittekind Ch (eds) (2002) U1CC, International Union against Cancer, TNM Classification of Malignant Tumours, 6th edn. Wiley-Liss, New York
Greenberg JS, El Naggar AK, Mo V et al (2003) Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma Implication for therapeutic decision making. Cancer 98:508–551
Woolgar JA (2007) The topography of cervical lymph node metastases revisited: the histological findings in 526 sides of neck dissection from 439 previously untreated patients. Int J Oral Maxillofac Surg 36:219–225
Ferlito A, Shaha AR, Silver CE et al (2001) Incidence and sites of distant metastases from head and neck cancer. Otorhinolaryngol 63:202–220
Woolgar JA, Rogers S, West CR et al (1999) Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection. Oral Oncol 35:257–265
Woolgar JA (2006) Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol 42:229–239
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Italia
About this chapter
Cite this chapter
Woolgar, J.A., Triantafyllou, A. (2011). Istopatologia dei tumori squamocellulari. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_4
Download citation
DOI: https://doi.org/10.1007/978-88-470-1806-8_4
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1805-1
Online ISBN: 978-88-470-1806-8
eBook Packages: MedicineMedicine (R0)