Abstract
During the past 10 years significant achievements have been made in the treatment of p–thalassemia major. Nevertheless, the improved survival of these patients has led to the appearance of several complications, which now represent the major clinical problems in the disease. Endocrine disorders are very common, and growth failure is one of the most frequent. Short stature is present in approximately 30% of our thalassemic patients (n = 200). However, the pathogenesis of the growth disturbances of thalassemic patients has not yet been elucidated. The role of growth hormone (GH) deficiency in the growth impairment of these patients is controversial. Hence, we have studied GH secretion in a group of thalassemic patients with short stature.
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References
Tanner JM, Whitehouse RH, Marshall WA, Healy MJR, Goldstein H (1975) Assessment of skeletal maturity and prediction of adult height (TW2 method). Academic, London
Tanner JM, Whitehouse RH (1976) Clinical and longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 51: 170–179
Kowarski A, Thompson RG, Migeon CJ, Blizzard RM (1971) Determination of integrated plasma concentration and true secretion rate of human growth hormone. J Clin Endocrinol Metab 32: 356–360
Arcasoy A, Cavdar AC (1975) Changes in trace minerals (serum iron, zinc, copper and magnesium) in thalassemia.,Acta Haematol (Basel) 53: 341–346
De Virgilis S, Congia M, Frau F, Argiolu F, Diana G, Cucca F, Varsi A, Sanna G, Podda G, Fodde M, Pirastu FGF, Cao A (1988) Deferoxamine-induced growth retardation in patients with thalassemia major. J Pediatr 113: 661–669
Rivolta MR, De Micheli A, Capra M, Gelosa M, Lange E, Monguzzi W (1987) Growth hormone response to hypoglycemic stress in thalassemia major (Abstr). J Endocrinol Invest 10 [Suppl] 4: 84
Saenger P, Schwartz E, Markenson AL, Graziano JH, Levine LS, New MI, Hilgartner MW (1980) Depressed serum somatomedin activity in beta-thalassemia. J Pediatr 96: 214–218
Pintor C, Cella S, Manso P, Corda R, Dessi C, Locatelli V, Muller EE (1986) Impaired growth hormone ( GH) response to GH-releasing hormone in thalassemia major. J Clin Endocrinol Metab 62: 263–267
Shehadeh N, Hazan A, Rudolf MCJ, Peleg I, Benderly A, Hochberg Z (1990) Neurosecretory dysfunction of growth hormone secretion in thalassemia major. Acta Paediatr Scand 79: 790–795
Borgna-Pignatti C, De Stefano P, Zonta L, Vullo C, De Sanctis V, Melevendi C, Naselli A, Masera G, Terzoli S, Gabutti V, Piga A (1985) Growth and sexual maturation in thalassemia major. J Pediatr 106: 150–155
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© 1995 Springer-Verlag Berlin Heidelberg
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Caruso-Nicoletti, M. et al. (1995). Growth Hormone Secretion in Thalassemic Patients. In: Andò, S., Brancati, C. (eds) Endocrine Disorders in Thalassemia. Springer, Milano. https://doi.org/10.1007/978-88-470-2183-9_18
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DOI: https://doi.org/10.1007/978-88-470-2183-9_18
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2185-3
Online ISBN: 978-88-470-2183-9
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