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New Animal Models of Lymphangiogenesis

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Lymphangiogenesis in Cancer Metastasis

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 13))

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Abstract

The discovery of new genes, genetic pathways and drug targets involved in the formation of lymphatic vessels and capillaries has long been hampered by the absence of a small model organism amenable to large scale genetic and pharmacological screening. The recent description of functional and conserved lymphatic vascular systems in the two small animal models Xenopus laevis (the African clawed frog) and Danio rerio (the zebrafish) now opens up the possibility to exploit these models for the study of developmental lymphangiogenesis. In this chapter we will describe the discovery and characterisation of the lymphatic vasculature in both frog and fish models. We will also describe and compare the available genetic tools for the study of lymphangiogenesis in these new model systems.

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  1. Hubrecht Institute (KNAW), University Medical Center Utrecht, 3584, Utrecht, CT, The Netherlands

    Benjamin M. Hogan & Stefan Schulte-Merker

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Hogan, B.M., Schulte-Merker, S. (2009). New Animal Models of Lymphangiogenesis. In: Lymphangiogenesis in Cancer Metastasis. Cancer Metastasis – Biology and Treatment, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2247-9_3

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