Skip to main content
SpringerLink
Log in

Dietary Restriction and Aging in Drosophila Melanogaster

  • Chapter
  • First Online:
Calorie Restriction, Aging and Longevity

  • 1890 Accesses

Abstract

Dietary restriction (DR), the reduction of nutrient intake without causing malnutrition, is one environmental intervention that has been shown to extend the life span of a variety of organisms. Drosophila melanogaster is ideally suited for experiments into the biological effects of DR and aging due to its short life span and thorough characterization at the molecular and genetic level. Furthermore, the simple sugar/yeast diet (corresponding to carbohydrate and protein sources respectively) for Drosophila can be easily manipulated and is therefore amenable to experiments designed to determine the relative importance of the different food components (or caloric content) to life span. Although which aspect of nutrition is most important to fly longevity has not yet been determined, DR experiments have shown that many behaviors and functions, including cognition, olfaction and female fecundity, are influenced by the fly’s nutritional status. Genetic studies have identified numerous signaling pathways, including the insulin-like signaling, target of rapamycin and sirtuin pathways, as potential mediators between DR and life span. Most of these pathways are evolutionarily conserved. Therefore, results from DR studies in Drosophila should help with the development of therapeutic interventions to slow the aging process in higher organisms, including humans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bass, T. M., Grandison, R. C., Wong, R., Martinez, P., Partridge, L. and Piper, M. D., 2007a. Optimization of dietary restriction protocols in Drosophila. J Gerontol A Biol Sci Med Sci 62, 1071–1081.

    Article  PubMed  Google Scholar 

  • Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D. and Partridge, L., 2007b. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev 128, 546–552.

    Article  PubMed  CAS  Google Scholar 

  • Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M. and Helfand, S. L., 2005. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15, 2063–2068.

    Article  PubMed  CAS  Google Scholar 

  • Bhandari, P., Jones, M. A., Martin, I. and Grotewiel, M. S., 2007. Dietary restriction alters demographic but not behavioral aging in Drosophila. Aging Cell 6, 631–637.

    Article  PubMed  CAS  Google Scholar 

  • Brand, A. H. and Perrimon, N., 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415.

    PubMed  CAS  Google Scholar 

  • Bross, T. G., Rogina, B. and Helfand, S. L., 2005. Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. Aging Cell 4, 309–317.

    Article  PubMed  CAS  Google Scholar 

  • Broughton, S. and Partridge, L., 2009. Insulin/IGF-like signalling, the central nervous system and aging. Biochem J 418, 1–12.

    Article  PubMed  CAS  Google Scholar 

  • Brown-Borg, H. M., Borg, K. E., Meliska, C. J. and Bartke, A., 1996. Dwarf mice and the ageing process. Nature 384, 33.

    Article  PubMed  CAS  Google Scholar 

  • Burger, J. M., Hwangbo, D. S., Corby-Harris, V. and Promislow, D. E., 2007. The functional costs and benefits of dietary restriction in Drosophila. Aging Cell 6, 63–71.

    Article  PubMed  CAS  Google Scholar 

  • Carey, J. R., Harshman, L. G., Liedo, P., Muller, H. G., Wang, J. L. and Zhang, Z., 2008. Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. Aging Cell 7, 470–477.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho, G. B., Kapahi, P. and Benzer, S., 2005. Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat Methods 2, 813–815.

    Article  PubMed  CAS  Google Scholar 

  • Chapman, T. and Partridge, L., 1996. Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. Proc Biol Sci 263, 755–759.

    Article  PubMed  CAS  Google Scholar 

  • Chippindale, A., Leroi, A. M., Kim, S. B. and Rose, M. R., 1993. Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction. J Evol Biol 6, 171–193.

    Article  Google Scholar 

  • Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J. and Partridge, L., 2002. Dietary restriction in long-lived dwarf flies. Science 296, 319.

    Article  PubMed  CAS  Google Scholar 

  • Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J. and Partridge, L., 2001. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104–106.

    Article  PubMed  CAS  Google Scholar 

  • Coschigano, K. T., Clemmons, D., Bellush, L. L. and Kopchick, J. J., 2000. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141, 2608–2613.

    Article  PubMed  CAS  Google Scholar 

  • Das, S., Boswell, S. A., Aaronson, S. A. and Lee, S. W., 2008. p53 promoter selection: choosing between life and death. Cell Cycle 7, 154–157.

    Article  PubMed  CAS  Google Scholar 

  • De Marte, M. L. and Enesco, H. E., 1986. Influence of low tryptophan diet on survival and organ growth in mice. Mech Ageing Dev 36, 161–171.

    Article  PubMed  Google Scholar 

  • Driver, C. J., Wallis, R., Cosopodiotis, G. and Ettershank, G., 1986. Is a fat metabolite the major diet dependent accelerator of aging? Exp Gerontol 21, 497–507.

    Article  PubMed  CAS  Google Scholar 

  • Duffy, J. B., 2002. GAL4 system in Drosophila: a fly geneticist’s Swiss army knife. Genesis 34, 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Edgar, B. A., 2006. How flies get their size: genetics meets physiology. Nat Rev Genet 7, 907–916.

    Article  PubMed  CAS  Google Scholar 

  • Edgecomb, R. S., Harth, C. E. and Schneiderman, A. M., 1994. Regulation of feeding behavior in adult Drosophila melanogaster varies with feeding regime and nutritional state. J Exp Biol 197, 215–235.

    PubMed  CAS  Google Scholar 

  • Gao, X. and Pan, D., 2001. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 15, 1383–1392.

    Article  PubMed  CAS  Google Scholar 

  • Giannakou, M. E., Goss, M. and Partridge, L., 2008. Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7, 187–198.

    Article  PubMed  CAS  Google Scholar 

  • Giannakou, M. E. and Partridge, L., 2004. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol 14, 408–412.

    Article  PubMed  CAS  Google Scholar 

  • Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P. and Brunet, A., 2007. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17, 1646–1656.

    Article  PubMed  CAS  Google Scholar 

  • Helfand, S. L. and Rogina, B., 2003. Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet 37, 329–348.

    Article  PubMed  CAS  Google Scholar 

  • Holehan, A. M. and Merry, B. J., 1985. Lifetime breeding studies in fully-fed and dietary restricted female CFY Sprague-Dawley rats. 1. Effect of age, housing conditions and diet on fecundity. Mech Ageing Dev 33, 19–28.

    Article  PubMed  CAS  Google Scholar 

  • Houthoofd, K., Braeckman, B. P., Johnson, T. E. and Vanfleteren, J. R., 2003. Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp Gerontol 38, 947–954.

    Article  PubMed  CAS  Google Scholar 

  • Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., Scherer, B. and Sinclair, D. A., 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191–196.

    Article  PubMed  CAS  Google Scholar 

  • Hulbert, A. J., Clancy, D. J., Mair, W., Braeckman, B. P., Gems, D. and Partridge, L., 2004. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol 39, 1137–1143.

    Article  PubMed  CAS  Google Scholar 

  • Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T. and Benzer, S., 2007. Prandiology of Drosophila and the CAFE assay. Proc Natl Acad Sci USA 104, 8253–8256.

    Article  PubMed  CAS  Google Scholar 

  • Junger, M. A., Rintelen, F., Stocker, H., Wasserman, J. D., Vegh, M., Radimerski, T., Greenberg, M. E. and Hafen, E., 2003. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2, 20.

    Article  PubMed  Google Scholar 

  • Kabil, H., Partridge, L. and Harshman, L. G., 2007. Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution. Biogerontology 8, 201–208.

    Article  PubMed  CAS  Google Scholar 

  • Kaeberlein, M. and Kennedy, B. K., 2007. Does resveratrol activate yeast Sir2 in vivo? Aging Cell 6, 415–416.

    Article  PubMed  CAS  Google Scholar 

  • Kaeberlein, T. L., Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Fields, S., Kennedy, B. K. and Kaeberlein, M., 2006. Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5, 487–494.

    Article  PubMed  CAS  Google Scholar 

  • Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. and Benzer, S., 2004. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14, 885–890.

    Article  PubMed  CAS  Google Scholar 

  • Klass, M. R., 1977. Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6, 413–429.

    Article  PubMed  CAS  Google Scholar 

  • Lakowski, B. and Hekimi, S., 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci USA 95, 13091–13096.

    Article  PubMed  CAS  Google Scholar 

  • Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W., Taylor, P. W., Soran, N. and Raubenheimer, D., 2008. Lifespan and reproduction in drosophila: new insights from nutritional geometry. Proc Natl Acad Sci USA 105, 2498–2503.

    Article  PubMed  CAS  Google Scholar 

  • Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., de Cabo, R., Ingram, D. K. and Zou, S., 2006. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5, 515–524.

    Article  PubMed  CAS  Google Scholar 

  • Libert, S. and Pletcher, S. D., 2007. Modulation of longevity by environmental sensing. Cell 131, 1231–1234.

    Article  PubMed  CAS  Google Scholar 

  • Libert, S., Zwiener, J., Chu, X., Vanvoorhies, W., Roman, G. and Pletcher, S. D., 2007. Regulation of Drosophila life span by olfaction and food-derived odors. Science 315, 1133–1137.

    Article  PubMed  CAS  Google Scholar 

  • Lin, S. J., Defossez, P. A. and Guarente, L., 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126–2128.

    Article  PubMed  CAS  Google Scholar 

  • Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L. and Gu, W., 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137–148.

    Article  PubMed  CAS  Google Scholar 

  • Magwere, T., Goodall, S., Skepper, J., Mair, W., Brand, M. D. and Partridge, L., 2006. The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila. J Gerontol A Biol Sci Med Sci 61, 36–47.

    Article  PubMed  Google Scholar 

  • Mair, W., Piper, M. D. and Partridge, L., 2005. Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3, e223.

    Article  PubMed  Google Scholar 

  • Mair, W., Sgro, C. M., Johnson, A. P., Chapman, T. and Partridge, L., 2004. Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. Exp Gerontol 39, 1011–1019.

    Article  PubMed  CAS  Google Scholar 

  • Marygold, S. J. and Leevers, S. J., 2002. Growth signaling: TSC takes its place. Curr Biol 12, R785–R787.

    Article  PubMed  CAS  Google Scholar 

  • Masoro, E. J., 1988a. Food restriction in rodents: an evaluation of its role in the study of aging. J Gerontol 43, B59–B64.

    Article  PubMed  CAS  Google Scholar 

  • Masoro, E. J., 1988b. Life span extension and food restriction. Compr Ther 14, 9–13.

    PubMed  CAS  Google Scholar 

  • Masoro, E. J., 2005. Overview of caloric restriction and ageing. Mech Ageing Dev 126, 913–922.

    Article  PubMed  CAS  Google Scholar 

  • Masoro, E. J., 2007. Role of hormesis in life extension by caloric restriction. Dose Response 5, 163–173.

    Article  Google Scholar 

  • Merry, B. J., 2002. Molecular mechanisms linking calorie restriction and longevity. Int J Biochem Cell Biol 34, 1340–1354.

    Article  PubMed  CAS  Google Scholar 

  • Min, K. J., Flatt, T., Kulaots, I. and Tatar, M., 2007. Counting calories in Drosophila diet restriction. Exp Gerontol 42, 247–251.

    Article  PubMed  Google Scholar 

  • Min, K. J. and Tatar, M., 2006a. Drosophila diet restriction in practice: do flies consume fewer nutrients? Mech Ageing Dev 127, 93–96.

    Article  PubMed  CAS  Google Scholar 

  • Min, K. J. and Tatar, M., 2006b. Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech Ageing Dev 127, 643–646.

    Article  PubMed  CAS  Google Scholar 

  • Min, K. J., Yamamoto, R., Buch, S., Pankratz, M. and Tatar, M., 2008. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell 7, 199–206.

    Article  PubMed  CAS  Google Scholar 

  • Miquel, J., Lundgren, P. R., Bensch, K. G. and Atlan, H., 1976. Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mech Ageing Dev 5, 347–370.

    Article  PubMed  CAS  Google Scholar 

  • Miwa, S., Riyahi, K., Partridge, L. and Brand, M. D., 2004. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci 1019, 388–391.

    Article  PubMed  CAS  Google Scholar 

  • Miwa, S., St-Pierre, J., Partridge, L. and Brand, M. D., 2003. Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med 35, 938–948.

    Article  PubMed  CAS  Google Scholar 

  • Orentreich, N., Matias, J. R., DeFelice, A. and Zimmerman, J. A., 1993. Low methionine ingestion by rats extends life span. J Nutr 123, 269–274.

    PubMed  CAS  Google Scholar 

  • O’Brien, D. M., Min, K. J., Larsen, T. and Tatar, M., 2008. Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan. Curr Biol 18, R.

    Google Scholar 

  • Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J. and Dillin, A., 2007. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447, 550–555.

    Article  PubMed  CAS  Google Scholar 

  • Partridge, L., Piper, M. D. and Mair, W., 2005. Dietary restriction in Drosophila. Mech Ageing Dev 126, 938–950.

    Article  PubMed  CAS  Google Scholar 

  • Piper, M. D. and Bartke, A., 2008. Diet and aging. Cell Metab 8, 99–104.

    Article  PubMed  CAS  Google Scholar 

  • Piper, M., Mair, W. and Partridge, L., 2007. Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) Counting calories in Drosophila dietary restriction. Exp Gerontol 42, 253–255.

    Article  PubMed  Google Scholar 

  • Pletcher, S. D., Macdonald, S. J., Marguerie, R., Certa, U., Stearns, S. C., Goldstein, D. B. and Partridge, L., 2002. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 12, 712–723.

    Article  PubMed  CAS  Google Scholar 

  • Poirier, L. and Seroude, L., 2005. Genetic approaches to study aging in Drosophila melanogaster. AGE 27, 165–182.

    Article  CAS  Google Scholar 

  • Rattan, S. I., 2008. Hormesis in aging. Ageing Res Rev 7, 63–78.

    Article  PubMed  Google Scholar 

  • Richie, J. P., Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N. and Zimmerman, J. A., 1994. Methionine restriction increases blood glutathione and longevity in F344 rats. Faseb J 8, 1302–1307.

    PubMed  CAS  Google Scholar 

  • Rogina, B. and Helfand, S. L., 2004. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101, 15998–16003.

    Article  PubMed  CAS  Google Scholar 

  • Rogina, B., Helfand, S. L. and Frankel, S., 2002. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 298, 1745.

    Article  PubMed  CAS  Google Scholar 

  • Skorupa, D. A., Dervisefendic, A., Zwiener, J. and Pletcher, S. D., 2008. Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell 7, 478–490.

    Article  PubMed  CAS  Google Scholar 

  • Soh, J. W., Hotic, S. and Arking, R., 2007. Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity. Mech Ageing Dev 128, 581–593.

    Article  PubMed  CAS  Google Scholar 

  • Sohal, R. S. and Weindruch, R., 1996. Oxidative stress, caloric restriction, and aging. Science 273, 59–63.

    Article  PubMed  CAS  Google Scholar 

  • Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L. and Khan, A. S., 1999. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J Gerontol A Biol Sci Med Sci 54, B521–B538.

    Article  PubMed  CAS  Google Scholar 

  • Speakman, J. R., Selman, C., McLaren, J. S. and Harper, E. J., 2002. Living fast, dying when? The link between aging and energetics. J Nutr 132, 1583S–1597S.

    PubMed  CAS  Google Scholar 

  • Troen, A. M., French, F. E., Roberts, J. F., Selhub, J., Ordovas, J. M., Parnell, L. D. and Lai, C. Q., 2007. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. AGE 29, 29–39.

    Article  PubMed  CAS  Google Scholar 

  • Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L. and Weinberg, R. A., 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149–159.

    Article  PubMed  CAS  Google Scholar 

  • Wang, M. C., Bohmann, D. and Jasper, H., 2003. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 5, 811–816.

    Article  PubMed  CAS  Google Scholar 

  • Wang, M. C., Bohmann, D. and Jasper, H., 2005. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115–125.

    Article  PubMed  CAS  Google Scholar 

  • Wong, R., Piper, M. D., Blanc, E. and Partridge, L., 2008. Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. Nat Methods 5, 214–215. author reply 215.

    Article  PubMed  CAS  Google Scholar 

  • Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M. and Sinclair, D., 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.

    Article  PubMed  CAS  Google Scholar 

  • Yamazaki, D., Horiuchi, J., Nakagami, Y., Nagano, S., Tamura, T. and Saitoe, M., 2007. The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan. Nat Neurosci 10, 478–484.

    PubMed  CAS  Google Scholar 

  • Zheng, J., Edelman, S. W., Tharmarajah, G., Walker, D. W., Pletcher, S. D. and Seroude, L., 2005a. Differential patterns of apoptosis in response to aging in Drosophila. Proc Natl Acad Sci USA 102, 12083–12088.

    Article  PubMed  CAS  Google Scholar 

  • Zheng, J., Mutcherson, R., II and Helfand, S. L., 2005b. Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell 4, 209–216.

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman, J. A., Malloy, V., Krajcik, R. and Orentreich, N., 2003. Nutritional control of aging. Exp Gerontol 38, 47–52.

    Article  PubMed  CAS  Google Scholar 

  • Zou, S., Carey, J. R., Liedo, P., Ingram, D. K., Muller, H. G., Wang, J. L., Yao, F., Yu, B. and Zhou, A., 2009. The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp Gerontol. 44, 472–476.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, MD, 21224, USA

    Luc Poirier & Sige Zou

  2. Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    Rafael de Cabo

Authors
  1. Luc Poirier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rafael de Cabo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sige Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sydney, 2006, Australia

    Arthur V. Everitt

  2. University of Aarhus, University of Aarhus, Aarhus, 8000, Denmark

    Suresh I. S. Rattan

  3. Sydney, 2006, Australia

    David G. le Couteur

  4. National Institute on Aging, Gerontology Research Center, National Institute of Health, Nathan Shock Drive 5600, Baltimore, 21224, USA

    Rafael de Cabo

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Poirier, L., de Cabo, R., Zou, S. (2010). Dietary Restriction and Aging in Drosophila Melanogaster . In: Everitt, A., Rattan, S., le Couteur, D., de Cabo, R. (eds) Calorie Restriction, Aging and Longevity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8556-6_5

Download citation

Publish with us

Policies and ethics

Search

Navigation