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Bioreactor Systems in Regenerative Medicine

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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Abstract

In this chapter, the functions and potential applicability of bioreactors from a technical, scientific and clinical perspective will be reviewed in the context of tissue engineering and regenerative medicine. In particular, examples will be given to illustrate the role of bioreactors in (a) establishing and maintaining 3D cell cultures, (b) standardizing physicochemical culture parameters, (c) physically conditioning engineered grafts, (d) predicting mechanical functionality of constructs to be implanted, (e) automating conventional tissue culture processes, (f) streamlining tissue manufacturing strategies. The critical role of bioreactors to make tissue engineered products clinically accessible, safe and commercially competitive will finally be discussed.

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Authors and Affiliations

  1. Institute for Surgical Research and Hospital Management, Departments of Surgery and of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland

    Ivan Martin, Stefania A. Riboldi & David Wendt

Authors
  1. Ivan Martin
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  2. Stefania A. Riboldi
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  3. David Wendt
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Corresponding author

Correspondence to Ivan Martin .

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Editors and Affiliations

  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Martin, I., Riboldi, S.A., Wendt, D. (2010). Bioreactor Systems in Regenerative Medicine. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_6

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