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Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Aim of this review is to give an overview and discuss recent findings on the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.

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Acknowledgements

Supported by grants from the DFG through a Heisenberg-grant (MA 1982/4-1), a grant for a Clinical Research group KFO155 (MA 1982/2-1), and the Fondation Leducq Award to the Alliance for Calmodulin Kinase Signaling in Heart Disease.

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  1. Department of Cardiology and Pneumology/Heart Center, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Lars S. Maier MD, FESC, FAHA (Heisenberg-Professor)

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  1. Lars S. Maier MD, FESC, FAHA
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Correspondence to Lars S. Maier MD, FESC, FAHA .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Maier, L.S. (2012). Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_30

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