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The Origin of First Peptides on Earth: From Amino Acids to Homochiral Biomolecules

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Genesis - In The Beginning

Part of the book series: Cellular Origin, Life in Extreme Habitats and Astrobiology ((COLE,volume 22))

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Abstract

From general considerations about the formation of first biomolecules in a primordial Earth scenario, it is concluded that amino acids, peptides and proteins are the compounds with the highest probability to be formed first. Consequently, possible formation reactions for these compounds and related simulation experiments are presented, in particular Miller-type experiments for the synthesis of amino acids and condensation reactions leading to peptides. Among the latter, especially the salt-induced peptide formation (SIPF) reaction is discussed, as it is based on a very simple and variable scenario, and offers a number of explanations for phenomena still observed in present life forms. This pertains to non-statistical amino acid sequences, the type of preferably used amino acids and to the l-homochirality of proteins in all life forms on Earth.

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Acknowledgments

This work was financially supported by the Austrian Science Foundation (Fonds zur Förderung der wissenschaftlichen Forschung, Projekt P19334-N17), which is gratefully appreciated.

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  1. Division of Theoretical Chemistry, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, A-6020, Innsbruck, Austria

    Thomas Jakschitz, Daniel Fitz & Bernd Michael Rode

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  1. Thomas Jakschitz
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  2. Daniel Fitz
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  3. Bernd Michael Rode
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Correspondence to Thomas Jakschitz .

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  1. University of Jerusalem, Mevo Hadas 20, Efrat, 90435, Israel

    Joseph Seckbach

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Jakschitz, T., Fitz, D., Rode, B.M. (2012). The Origin of First Peptides on Earth: From Amino Acids to Homochiral Biomolecules. In: Seckbach, J. (eds) Genesis - In The Beginning. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2941-4_25

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