Abstract
Tobacco use is the leading preventable cause of death in the United States. Recent research in Hematopoietic Stem Cell Transplant (HSCT) populations has begun to examine smoking cigarettes as a risk factor for adverse transplant outcomes. Based on these early studies, estimated prevalence rates vary widely. Lifetime history of smoking among HSCT patients likely approximates that of the general population, while current use appears less than the general population. Smoking has been associated with multiple adverse HSCT outcomes, including shorter duration of disease-free and overall survival; higher treatment related mortality; higher pulmonary infection and respiratory failure rates; higher rates of disease recurrence; increased risk for cardiovascular events; and longer duration of hospitalization. Potential mechanisms are likely many, and include impaired bone marrow hematopoiesis, inflammation, impaired pulmonary function, and also significant associations with other maladaptive health behaviors know to adversely affect general population health outcomes, but understudied in HSCT populations. Future directions for tobacco research in HSCT should focus on use of behavior science methodology to minimize biases common to self-report methodology, and analyzing the effects of both current and lifetime use. Current use is a modifiable risk factor. Cancer diagnosis and HSCT serve as “teachable moments” during which patient motivation to quit tobacco use is increased. Survivor care plans serve as a timely platform for integration of evidence-based tobacco dependence treatment into a comprehensive care plan that targets all known significant risk factors to optimize HSCT outcomes.
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References
American Cancer Society (ACS) (2011) American Cancer Society. Cancer facts and figures 2011. Retrieved from http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/cancer-facts-figures-2011. Accessed 30 June 2011
Bishop MM, Lee SJ, Beaumont JL, Andrykowski MA, Rizzo JD, Sobocinski KA et al (2010) The preventive health behaviors of long-term survivors of cancer and hematopoietic stem cell transplantation compared with matched controls. Biol Blood Marrow Transplant 16:207–214
Blanchard CM, Courneya KS, Stein K (2008) Cancer survivors’ adherence to lifestyle behavior recommendations and associations with health-related quality of life: results from the American Cancer Society’s SCS-II. J Clin Oncol 26:2198–2204
Centers for Disease Control (CDC) (2009) Cigarette smoking among adults and trends in smoking cessation – United States, 2008. MMWR Morb Mortal Wkly Rep 58:1227–1232
Centers for Disease Control (CDC) (2011) Quitting smoking among adults – United States, 2001–2010. MMWR Morb Mortal Wkly Rep 60:1513–1519
Chang G, Orav EJ, McNamara T, Tong MY, Antin JH (2004a) Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome. Cancer 101:782–789
Chang G, Orav EJ, Tong M-Y, Antin JH (2004b) Predictors of 1-year survival assessed at the time of bone marrow transplantation. Psychosomatics 45:378–385
Chelghoum Y, Danaïla C, Belhabri A, Charrin C, Le QH, Michallet M et al (2002) Influence of cigarette smoking on the presentation and course of acute myeloid leukemia. Ann Oncol 13:1621–1627
Cooke J, Bitterman H (2004) Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Ann Med 36:33–40
Cooley ME, Emmons KM, Haddad R, Wang Q, Posner M, Bueno R et al (2011) Patient-reported receipt of and interest in smoking-cessation interventions after a diagnosis of cancer. Cancer 117:2961–2969
Coups EJ, Ostroff JS (2005) A population-based estimate of the prevalence of behavioral risk factors among adult cancer survivors and noncancer controls. Prev Med 40:702–711
Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B et al (2006) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 56:323–353
Ehlers SL, Gastineau DA, Patten CA, Decker PA, Rausch SM, Cerhan JR et al (2011) The impact of smoking on outcomes among patients undergoing hematopoietic SCT for the treatment of acute leukemia. Bone Marrow Transplant 46:285–290
Fiore MC, Jaen CR, Baker TB, Bailey WC, Benowitz N, Curry SJ et al (2008) Treating tobacco use and dependence. Clinical Practice Guideline, p 257
Geyer SM, Morton LM, Habermann TM, Allmer C, Davis S, Cozen W et al (2010) Smoking, alcohol use, obesity, and overall survival from non-Hodgkin lymphoma. Cancer 116:2993–3000
Gritz ER, Fingeret MC, Vidrine DJ, Lazev AB, Mehta NV, Reece GP (2006) Successes and failures of the teachable moment. Cancer 106:17–27
Gritz ER, Lam CY, Vidrine DJ, Cororve MF (2008) Cancer prevention: tobacco dependence and its treatment. In: DeVita V, Lawrence T, Rosenberg S (eds) Cancer: principles and practice of oncology, 8th edn. Lippincott, Williams, and Wilkins, Philadelphia, pp 593–608
Ho VT, Weller E, Lee SJ, Alyea EP, Antin JH, Soiffer RJ (2001) Prognostic factors for early severe pulmonary complications after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 7:223–229
Hoodin F, Kalbfleisch KR, Thornton J, Ratanatharathorn V (2004) Psychosocial influences on 305 adults’ survival after bone marrow transplantation: depression, smoking, and behavioral self-regulation. J Psychosom Res 57:145–154
Hsu CC-T, Kwan GNC, Chawla A, Mitina N, Christie D (2011) Smoking habits of radiotherapy patients: did the diagnosis of cancer make an impact and is there an opportunity to intervene? J Med Imaging Radiat Oncol 55:526–531
Levitz JS, Bradley TP, Golden AL (2004) Overview of smoking and all cancers. Med Clin North Am 88:1655–1675
Marks DI, Ballen K, Logan BR, Wang Z, Sobocinski KA, Bacigalupo A et al (2009) The effect of smoking on allogeneic transplant outcomes. Biol Blood Marrow Transplant 15:1277–1287
Miceli MH, Dong L, Grazziutti ML, Fassas A, Thertulien R, Van Rhee F et al (2006) Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: a study of 367 myeloma patients. Bone Marrow Transplant 37:857–864
Mokdad AH, Marks JS, Stroup DF, Gerberding JL (2004) Actual causes of death in the United States, 2000. JAMA 291:1238–1245
Sandler DP, Shore DL, Anderson JR, Davey FR, Arthur D, Mayer RJ et al (1993) Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow. J Natl Cancer Inst 85:1994–2003
Savani BN, Montero A, Wu C, Nlonda N, Read E, Dunbar C et al (2005) Prediction and prevention of transplant-related mortality from pulmonary causes after total body irradiation and allogeneic stem cell transplantation. Biol Blood Marrow Transplant 11:223–230
Sharma S, Nadrous HF, Peters SG, Tefferi A, Litzow MR, Aubry M-C et al (2005) Pulmonary complications in adult blood and marrow transplant recipients. Chest 128:1385–1392
Spear MA, Dupuy DE, Park JJ, Halpern EF, Spiro IJ (1999) Tolerance of autologous and allogeneic bone grafts to therapeutic radiation in humans. Int J Radiat Oncol Biol Phys 45:1275–1280
Steenland K, Hu S, Walker J (2004) All-cause and cause-specific mortality by socioeconomic status among employed persons in 27 US States, 1984–1997. Am J Public Health 94:1037–1042
Thompson AM, Couch M, Zahurak ML, Johnson C, Vogelsang GB (2002) Risk factors for post-stem cell transplant sinusitis. Bone Marrow Transplant 29:257–261
Tichelli A, Passweg J, Wojcik D, Rovo A, Harousseau J-L, Masszi T et al (2008) Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Haematologica 93:1203–1210
Tran BT, Halperin A, Chien JW (2011) Cigarette smoking and outcomes after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 17:1004–1011
U. S. Department of Health and Human Services Office of Surgeon General (2010) How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease. Retreived from http://www.surgeongeneral.gov/library/tobaccosmoke/index.html. Accessed 10 July 2011
Varadarajan R, Cummings M, Hyland A, Wang E, Wetzler M (2010) Can decreasing smoking prevalence reduce leukemia mortality? Ann Hematol 89:873–876
Ward K, Klesges R (2001) A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int 68:259–270
Wilczynski SW, Erasmus JJ, Petros WP, Vredenburgh JJ, Folz RJ (1998) Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer. Am J Respir Crit Care Med 157:565–573
Zhou J, Eksioglu EA, Fortenbery NR, Chen X, Wang H, Epling-Burnette PK et al (2011) Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. PLoS One 6:e21173
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Ehlers, S., Bronars, C. (2012). Effect of Smoking on the Outcomes of Cancer Patients After Hematopoietic Stem Cell Transplantation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_32
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