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Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression

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Tumor Dormancy, Quiescence, and Senescence, Volume 2

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 2))

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Abstract

Transforming growth factor-beta (TGF-β) signaling pathway serves as a tumor suppressor by inhibiting cell cycle progression and stimulating senescence and apoptosis in normal and early-stages neoplastic tissues. As tumors progress, TGF-β signaling is often turned to drive multi-step metastasis processes by stimulating cell survival and epithelial-to-mesenchymal transition (EMT) leading to tumor cell migration and invasion. Many human carcinomas including triple-negative breast cancer, often show reduced or loss of key components of TGF-β signaling, indicating reduced tumor-suppressive TGF-β signaling may contribute to the cancer progression. However, molecular mechanisms that drive the switch of TGF-β are not well understood. Few molecular biomarkers have been identified as efficient indicators for the anti-TGF-β cancer therapy. In order to better understand the mechanism mediating the role of TGF-β during cancer progression, we will discuss the question of how the loss of control of cell proliferation and senescence by TGF-β promotes tumor invasion and metastasis and whether a set of transformation/metastasis-related genes are specifically regulated by TGF-β signaling.

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Acknowledgements

This work was in part supported by National Institutes of Health Grants R01CA75253 and R01CA79683.

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Authors and Affiliations

  1. Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, 78229, USA

    Shu Lin & Lu-Zhe Sun

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  1. Shu Lin
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  2. Lu-Zhe Sun
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Correspondence to Lu-Zhe Sun .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Lin, S., Sun, LZ. (2014). Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy and Cellular Quiescence and Senescence, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7726-2_21

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