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Vascular pharmacology of 5-hydroxytryptamine in humans

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

Forty yeas after its discovery the role of 5-hydroxytryptaine (5-HT) in the regulation of vascular tone in man still remains rather obscure. Soon after synthetic 5-HT became available it was shown that this monoamine influences vascular tone in a complex manner. Depending on the type of blood vessel and species investigate, as well as on the dose and route of administration, 5-HT was able to induce either vasodilatation or vasoconstriction [1, 2].

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Authors
  1. Gerald J. Blauw
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  2. Peter Van Brummelen
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  3. Pieter A. Van Zwieten
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Blauw, G.J., Brummelen, P.V., Van Zwieten, P.A. (1990). Vascular pharmacology of 5-hydroxytryptamine in humans. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_34

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_34

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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