Skip to main content
SpringerLink
Log in

Season of Operation and Differential Long-Term Progression: Clinical, Statistical, and Psychological Issues

  • Chapter
Mechanisms of Carcinogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 2))

  • 80 Accesses

Abstract

Seasonal or more precisely, “circannual” rhythms (23) have been reported for neoplastic processes in various contexts, both in the living organism and in isolated organ systems (29). In human patients, for example, specific peaks have been noted for certain months of the year — and as one might expect, questioned as well — over several decades (10, 21, 27, 29, 34, 44, 49). Moreover, the partial resemblance to cyclic trends of infections or vector-borne diseases may have helped to keep some of the simpler models of cancer causation alive. More recently research has focused on associated circannual, biological and hormonal parameters, hematological variables, receptor concentration, immune responses, and many investigations bearing on bioavailability (9, 16, 29, 31–33, 36, 46, 48, 51).

Empirical result and beginnings of a theoretical framework. Professor Dr. Dr. E.H. Krokowski died November 5, 1985. The editorial decision was made to leave the chapter essentially unchanged.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ader, R., and Cohen N. (1985): CNS-immune system interactions: conditioning phenomena. Behavior and Brain Sciences 8:379–426.

    Article  Google Scholar 

  2. Ader, R., Grota, L.J., and Cohen, N. (1987): Conditioning phenomena and immune function. In: Neuroimmune Interactions: Proceedings of the Second International Workshop on Neuroimmunomodulation (Jankovic, B.D., et al., eds), Annals of the New York Academy of Sciences, vol. 496, 532–544.

    Google Scholar 

  3. Agrimonti F, Angeli A, et al (1981): Circannual rhythmicities of Cortisol levels in the peripheral plasma of healthy subjects. Proceedings, 15th Congress Internat. Society for Chronobiol-ogy. Supplement, Chronobiologia 8,.

    Google Scholar 

  4. Alderson M (1975): Relationship between month of birth and month of death in the elderly. British Jour Preventive and Social Medicine 29:151–156.

    CAS  Google Scholar 

  5. Aschoff J (1967): Adaptive cycles: their significance for defining environmental hazards. Internat J Biometeorology 11:255–265.

    Article  Google Scholar 

  6. Bahnson CB, Bahnson M (1980, 1981): Stress and cancer: the state of the art. Part 1, Psychosomatics 21:975–980; Part 2, do., 22:207–220.

    PubMed  CAS  Google Scholar 

  7. Bailar JC III, Gurian JM (1964): Month of birth and cancer mortality. Jour Nat Cancer Institute 33:237–242.

    Google Scholar 

  8. Biener W (1984): Elementare Bedeutung der Quantenbiologie für den submolekularen Bereich der Medizin. Krebsgeschehen, Klinik und Praxis der Onkologie, Heft 5, 116–117.

    Google Scholar 

  9. Cairns J (1981): The origin of human cancers. Nature 289:353–357.

    Article  PubMed  CAS  Google Scholar 

  10. Cohen, P., Wax, Y., and Modan, B. (1983): Seasonality in the occurrence of breast cancer. Cancer Research, 43: 892–896.

    PubMed  CAS  Google Scholar 

  11. Dalen, P. (1975): Season of birth: a study of schizophrenia and other mental disorders. Amsterdam: North Holland.

    Google Scholar 

  12. Degenhardt, A., and Margraf, J. (1980): Die Zuverlässigkeit von Angaben über motorische Entwicklungsdaten in Anamneseerhebungen. Zeitschr f Differentielle und Diagnostische Psychologie, 1:291–302.

    Google Scholar 

  13. Deleanu, M., Lupsaiu, S., and Neumann, E. (1977): Seasonal fluctuations of some serum globulins in blood donors. J Inter-disciplin Cycle Research 8:243–245.

    Article  CAS  Google Scholar 

  14. DeSauvage Nolting, W.J.J. (1968): Seasonal variations in birth-rates of cancer patients. Internat J Biometeorology 12:293–295.

    Article  CAS  Google Scholar 

  15. Ertel, S. (1986): Ongoing research on environmental and rhythmic factors in psychophysiological processes. Psychology Labs., Univ. of Göttingen. (Personal communication).

    Google Scholar 

  16. Favier, F., Cupissol, Serrou, B. (1981): Lipids as biological response modifiers: effects on tumor growth in mice and on the immune response in cancer patients. Proceedings, 15th Congress Internatl. Society for Chronobiology. Supplement, Chronobiologia 8.

    Google Scholar 

  17. Fox, B.H., Newberry, B.H. (eds.) (1983): Impact of psychoendocrine systems in cancer and immunity. Lewiston, N.Y. and Toronto, Ont.: C.J. Hogrefe.

    Google Scholar 

  18. Gabriel K.R. (1966): Simultaneous test procedures for multiple comparison on categorical data. J Amer Statist Assn, 61:1081–1096.

    Article  Google Scholar 

  19. Gärtner, J., Schicketanz, K.H., Sinterhauf, K., Böhm, G. (1977): Jahreszeitliche Schwankungen im Vorkommen der idiopathischen Netzhautablösung und der Cortisolkonzentration in der subretinalen Flüssigkeit. Monatsblatt f Augenheilkunde, 171:506–519.

    Google Scholar 

  20. Halberg, F. (1982): Biological rhythms, hormones, and aging. In: Vernadakis, A., and Timiras, P.S. (eds.), Hormones in Development and Aging, chap. 13, 451–476. New York: Spectrum Publications.

    Google Scholar 

  21. Halberg, F., Haus, E., Nelson, W., and Sothern, R. (1977): Chronopharmacology, chronodietetics and eventually clinical chronotherapy. Nova Acta Leopoldina, 46: 307–336.

    CAS  Google Scholar 

  22. Halberg, F. (1983): Chronobiology and nutrition. Contemporary Nutrition, 8: No. 9, September, 2 pp. (Scientific Series edited by General Mills, Inc., P.O.B. 1113, Minneapolis, MN 55440).

    Google Scholar 

  23. Halberg, F., Carandente, F., Cornélissen, G., and Katinas, G.S. (1977): Glossary of chronobiology. Supplement, Chronobiologia, 4.

    Google Scholar 

  24. Halberg, F., Hrushesky, W.R. et al. (1987): Studies in progress, Chronobiology Laboratories, Univ. of Minnesota. (Personal communication).

    Google Scholar 

  25. Hare, E.H. (1978): Variations in the seasonal distribution of births of psychotic patients in England and Wales. Brit Jour Psychiatry 132:155–158.

    Article  CAS  Google Scholar 

  26. Harrison, A.A., Moore, M. (1983): Birth dates and death dates: a closer look. Omega 13:117–125.

    Google Scholar 

  27. Hayes, D.M. (1961): The seasonal incidence of acute leukemia. Cancer, 14:1301.

    Article  PubMed  CAS  Google Scholar 

  28. Haus, E., Halberg, F., Scheving, L., et al. (1972): Increased tolerance of leukemic mice to arabinosyl cytosine given on schedule adjusted to circadian system. Science, 177:80–82.

    Article  PubMed  CAS  Google Scholar 

  29. Haus, E., Lakatua, D.J., Swoyer, J., and Sackett-Lundeen, L. (1983): Chronobiology in hematology and immunology. Amer J Anatomy 168:467–517.

    Article  CAS  Google Scholar 

  30. Henry, J.P., Stephens, P.M. (eds.) (1977): Stress, health, and the social environment. A sociobiological approach to medicine. New York: Springer Verlag.

    Google Scholar 

  31. Hildebrandt, G. (1985): Chronobiologie in der Medizin. Ärztezeitschrift für Natur heilverfahr en, Physiothérapie, 26:135–152.

    Google Scholar 

  32. Hildebrandt, G., Hensel, H. (eds.) (1982): Biologische Adaptation. Stuttgart and New York: G. Thieme Verlag.

    Google Scholar 

  33. Hrushesky, W.R., Teslow, T., Halberg, F., Kiang, D., Kennedy, B.J. (1979): Temporal components of predictable variability along the one-year scale in estrogen receptor concentration of primary human breast cancer. Scientific Proceedings, Amer. Society of Clinical Oncology, 1979, A.S.C.O. Abstracts, March, 331.

    Google Scholar 

  34. Hrushesky, W.R., Jacobson, H., Halberg, F. (1984): Breast cancer diagnoses in New York State. Communication, Chronobiology Laboratories, University of Minnesota.

    Google Scholar 

  35. Jongbloet, P.H. (1970): Chromosomal aberrations and month of birth. The Lancet, Dec. 19, 1970, 1317–1318.

    Google Scholar 

  36. Koch, C.-D., Arnst, E., and Rommel, K. (1980): Interpretation von Serumproteinbefunden: individueller Normwert oder Referenzbereich? Das Medizinische Laboratorium, 33:2–16.

    PubMed  CAS  Google Scholar 

  37. Koch, C.-D., Arnst, E., Rommel, K. (1980): Langzeitverhalten von Enzymaktivitäten. Zentralblatt f Arbeitsmedizin, et al., 30:166–171.

    CAS  Google Scholar 

  38. Krokowski, E. (1978): Setzt die heutige Krebstherapie selbst die Grenze ihres Erfolges? Therapiewoche, 28:4700–4707.

    Google Scholar 

  39. Krokowski, E.H. (1981): The prevention of metastases as the central problem of future cancer therapy. In: Neoplasms. Comparative Pathology of Growth in Animals, Plants, and Man. H.E. Kaiser, (ed.) Baltimore: Williams and Wilkins. pp. 621–39.

    Google Scholar 

  40. Krokowski, E. (1984): Zur Frage der Krebsentstehung — ein ebenso schwieriger wie bedeutsamer Schritt in die submolekulare Dimension. Krebsgeschehen. Klinik und Praxis der Onkologie, 16:113–115.

    Google Scholar 

  41. Krokowski, E. (1984): Klinische Perspektiven, abgeleitet aus der quantenbiologischen Krebsforschung. Krebsgeschehen. Klinik und Praxis der Onkologie, 16: 117–120.

    Google Scholar 

  42. Krokowski, E. (ed.) (1979): Neue Aspekte der Krebsbekämpfung. Kritische Gedanken — Neue Wege. Stuttgart: G. Thieme.

    Google Scholar 

  43. Krokowski, E., Wendt, H.W. (1979): Season of surgery and metastatic risk in breast cancer: preliminary report. Chronobiologia, 6: 123 (abstr.)

    Google Scholar 

  44. Lee, J.A.H. (1967): Seasonal alterations and the natural history of malignant neoplasms. Progr. Clin. Cancer, 3:96–106.

    CAS  Google Scholar 

  45. Marx, J.L. (1982): Coagulation as a common thread in disease. Science, 218: 145–146.

    Article  PubMed  CAS  Google Scholar 

  46. Marx, J.L. (1983): Immunoglobulin genes have enhancers. Science, 221: 735–737.

    Article  PubMed  CAS  Google Scholar 

  47. Murray, J.B. (1983): Psychosomatic aspects of cancer: an overview. Jour Genetic Psychology, 136: 185–194.

    Google Scholar 

  48. Nicolau, G.Y., Lakatua, D., Sackett-Lundeen, L., and Haus, E. (1984): Circadian and circannual rhythms of hormonal variables in elderly men and women. Chronobiology International, 1: 301–319.

    Article  PubMed  CAS  Google Scholar 

  49. Price, C.H.G. (1959): A seasonal rhythm in the presentation of bone sarcoma in man. Nature, 184:B.A.76 (quoted after Lee, 1967, q.v.).

    Article  Google Scholar 

  50. Sklar, L.S., and Anisman, H. (1980): Social stress influences tumor growth. Psychosomatic Medicine, 42:347–365.

    PubMed  CAS  Google Scholar 

  51. Tomatis, L. (1983): Trends in cancer epidemiology. Jour Exp Cancer Research 3:257–260.

    Google Scholar 

  52. Watson, CG., Kucala, T., Angulski, G., and Brunn, С. (1982): Season of birth and schizophrenia: a response to the Lewis and Griffin critique. Jour Abnormal Psychology, 91:120–125.

    Google Scholar 

  53. Wendt, H.W. (1974): Early circannual rhythms and adult human behaviour: Components of a chronobehavioural theory, and critique of persistent artifacts. Internat Jour Chronobiology 2:57–86.

    CAS  Google Scholar 

  54. Wendt, H.W. (1976): Spurious correlation, revisited: a new look at the quantitative outcomes of sampling heterogeneous groups and/or at the wrong time. Archiv für Psychologie, 128:292–315.

    PubMed  CAS  Google Scholar 

  55. Wendt, H.W. (1977): Lernjahreszeit und Persönlichkeitsentwicklung: ein frühökologisches Modell. Psycholog. Rundschau, 28:266–292.

    Google Scholar 

  56. Wendt, H.W. (1978): Zum Problem jahreszeitlicher Adaptationseffekte in der Erwachsenen- und Frühökologie. Kolloquien des SFB Adaptation und Rehabilitation, SFB 122, Universität Marburg, Vol. 7:39–51.

    Google Scholar 

  57. Wendt, H.W., Krokowski, E.H.: Pre-mastectomy geomagnetic storms and postoperative metastatic risk. (Unpublished).

    Google Scholar 

  58. Werkmeister, H. (1985): Zur sogenannten biologischen Behandlung des Tumorkranken. Ärztezeitschr f Naturheilverfahren, 26:187–194.

    Google Scholar 

Download references

Authors
  1. E. H. Krokowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. W. Wendt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Homyak
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Elizabeth K. Weisburger

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Dordrecht

About this chapter

Cite this chapter

Krokowski, E.H., Wendt, H.W., Homyak, P.A. (1989). Season of Operation and Differential Long-Term Progression: Clinical, Statistical, and Psychological Issues. In: Weisburger, E.K. (eds) Mechanisms of Carcinogenesis. Cancer Growth and Progression, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2526-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-2526-7_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7641-8

  • Online ISBN: 978-94-009-2526-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation