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The Gramicidin Pore: Crystal Structure of a Gramicidin/Cesium Chloride Complex

  • Conference paper
Transport Through Membranes: Carriers, Channels and Pumps

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 21))

Abstract

The structure of the pore form of gramicidin has been determined at high resolution by X-ray crystallographic analysis of a gramicidin/cesium chloride complex. Not only do the conformations of the polypeptide backbone and side chains make clear how this molecule can form a pore, but the presence of ions in the structure also reveals the nature of the ligand-polypeptide interactions. A number of solvent molecules are visible in the pore and knowledge of their relationship to the ions forms a basis for understanding ion translocation.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Center for Biophysics Rensselaer Polytechnic Institute, Troy, New York, 12180, USA

    B. A. Wallace & K. Ravikumar

Authors
  1. B. A. Wallace
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  2. K. Ravikumar
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Alberte Pullman  & Bernard Pullman  & 

  2. Department of Chemistry, University of Tel-Aviv, Israel

    Joshua Jortner

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© 1988 Kluwer Academic Publishers

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Wallace, B.A., Ravikumar, K. (1988). The Gramicidin Pore: Crystal Structure of a Gramicidin/Cesium Chloride Complex. In: Pullman, A., Jortner, J., Pullman, B. (eds) Transport Through Membranes: Carriers, Channels and Pumps. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 21. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3075-9_8

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  • DOI: https://doi.org/10.1007/978-94-009-3075-9_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7882-5

  • Online ISBN: 978-94-009-3075-9

  • eBook Packages: Springer Book Archive

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