Abstract
The tissue distribution and elimination of 14C-labelled 1,2,3,4-, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene (TeCB) were investigated in the rat. All three tetrachlorobenzenes were rapidly absorbed and distributed in all tissues examined after oral administration; the highest concentrations were found in the fat, liver, skin and adrenal gland. Of the three isomers, tissues of 1,2,4,5- tetrachlorobenzene treated rats had the highest radioactivity measured at most sampling times; radioactivity in those of the other two isomers were lower and were of the same magnitude. The decay rates of the three isomers in the tissues were: 1,2,4,5-TeCB 105 hr; 1,2,3,4-TeCB 12 hr and 1,2,3,5-TeCB 6.5 hr, respectively.
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References
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© 1987 D. Reidel Publishing Company
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Chu, I., Villeneuve, D.C., Murdoch, D.J., Viau, A. (1987). Tissue Distribution and Elimination of 1,2,3,4-, 1,2,3,5- and 1,2,4,5-Tetrachlorobenzene in the Rat. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_5
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DOI: https://doi.org/10.1007/978-94-009-3937-0_5
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