Abstract
Immune complexes (IC) have been demonstrated in both serum (Tachovsky et al., 1977) and cerebrospinal fluid (CSF) (Glickmann et al., 1980) from patients with multiple sclerosis (MS). Weak but promising relations between clinical progression, the occurrence of circulating immune complexes (CIC) (Patzold et al., 1980) and fluctuations in the levels of complement factors C4, C3A and C3 (Jans et al., 1982) have been observed. Furthermore, hypocomplementaemia with low levels of C2, C3 and C3B (Trouillas & Betuel, 1977, Jans et. al. 1979), low levels of C4 and C9 in CSF (Jans et al., 1984; Morgan et al., 1984) and alterations in phenotypes of C4, C3 and C3B (Jans & Særensen, 1980, Fauchet et al., 1984) have been reported.
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References
Fauchet, R., Madigand, M., Gueguen-Duchesne, M. Y., Papin, J., Sabouraud, O. and Genetet, B., 1984. Les marqueurs BF et C4 du complement dans la sclerose en plaques. Rev. Neurol (Paris), 140: 422–425.
Fog,T. and Raun, N. E., 1976. Computerized forms in multiple sclerosis for medical history and full neurological examination. Kommune- hospitalet, DK 1399 Copenhagen
Glickmann, G., Svehag,S. -E., Hansen, E., Hansen, O., Husby,S., Nielsen, H and Farrel, C., 1980. Soluble immune complexes in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. Acta Neurol. Scand., 61: 333–343.
Jans,H., Jersild,E., Taaning, E., Dybkjaer, E., Fog,T. and Heltberg, A., 1979. The occurrence of immune complexes in multiple sclerosis. In Pro tides of the biological fluids 26, ed. H, Peeters, Pergamon Press, Oxford and New York, pp 255–258.
Jans,H. and Sørensen, H., 1980. C3 polymorphism and circulating immune complexes in patients with multiple sclerosis. Acta Neurol. Scand. 62: 237–243.
Jans,H., Heltberg,A. and Raun, N. E., 1982. Circulating immune complexes and complement in the course of multiple sclerosis. Acta Neurol. Scand., 66: 488–496.
Jans,H., Heltberg, A., Zeeberg, I., Halkjaer Kristensen, J., Fog,T. and Raun, N. E., 1984. Immune complexes and the complement factors C4 and C3 in cerebrospinal fluid and serum from patients with chronic progressive multiple sclerosis. Acta Neurol. Scand. 69: 34–38.
Morgan, B. P., Campbell, A. K. and Compston, D. A. S., 1984. Terminal component of complement C9 in cerebrospinal fluid of patients with multiple sclerosis. Lancet, i: 251–254.
Patzold, U., Haller, P., Baruth, B., Liman, W and Deicher, H., 1980. Immune complexes in multiple sclerosis. J. Neurol. 222: 249–260.
Schumacher, G. A., Beebe, G., Kibler, R. F., Kurland, L. T., Kurtzke, J. F., McDowell, F., Nagler, B., Sibley, W. A., Tourtellotte, W. W., and Willmon, T. L., 1965. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann. New York Acad. Sci., 122: 552–568.
Tachovsky, T. G., Lisak, R.P., Koprowski, H., Theofilopoulos, A. N., and Dixon, F. J., 1976. Circulating immune complexes in multiple sclerosis and other neurological diseases. Lancet, ii: 997–999.
Trouillas, P and Betuel, H., 1977. Hypocomplementaemic and normocomplementaemic multiple sclerosis. J. Neurol. Sci., 32: 425–435.
Woolf, B., 1955. On estimating the relation between blood group and disease. Ann. Hum. Genet. 19: 251–253.
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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg
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Jans, H. (1986). Immune Complexes and Complement in Multiple Sclerosis. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_37
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DOI: https://doi.org/10.1007/978-94-009-4143-4_37
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