Abstract
Pretreatment of guinea-pigs with the respiratory pathogen Haemophilus influenzae induces a deterioration of the pulmonary beta-adrenergic receptor system and hyperreactivity of the pulmonary cholinergic receptor system in vitro. This dysfunction of the autonomic nervous system is accompanied by a bronchial hyperreactivity to histamine in vivo, mediated by direct and reflex effects of histamine in the larger airways.
Guinea-pig pulmonary macrophages stimulated with serum from H. influenzae pretreated animals mimic the deteriorating influence on the beta-adrenergic system in the larger airways in vitro. A role for oxygen-centred radicals is suggested.
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Nijkamp, F.P., Engels, F., Folkerts, G. (1986). Modulation of autonomic receptor function by Haemophilus influenzae in the respiratory system. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_22
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DOI: https://doi.org/10.1007/978-94-009-4153-3_22
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