Abstract
Specialized methylotrophs, originally isolated for the specific biodégradation of chemical wastes, were found to be an excellent source of novel microbial enzymes, such as methylsulfatase, N,N-dimethylformamidase (DMFase), esterases, methanol dehydrogenase etc. The properties and possible applications of these microbes and enzymes are discussed. Mutant strains of Nocardia mediterranei (rifamycin producer) were successfully applied for the microbial production of D(−)-ribulose and shikimic acid.
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References
O. Ghisalba and M. Küenzi: ‘Biodegradation and utilization of monomethyl sulfate by specialized methylotrophs’ Experientia 39, 1257 (1983).
O. Ghisalba and M. Küenzi: ‘Biodegradation and utilization of quaternary alkylammonium compounds by specialized methylotrophs’ Experientia 39, 1264 (1983).
O. Ghisalba, P. Cevey, M. Küenzi and H.P. Schär: ‘Biodegradation of chemical waste by specialized methylotrophs, an alternative to physical methods of waste disposal’ in: IWTUS-3 Third International Waste Treatment and Utilization Symposium 1984, Pergamon Press in print.
C. Anthony: The Biochemistry of Methylotrophs, Academic Press (1982).
C. Fromageot: ‘Sulfatases and desulfinases’ Meth. Enzymol. 2, 324 (1955).
E.C. Sandberg and R.C. Jenkins: ‘Hydrolysis of the sulfuric acid esters of steroid compounds’ Meth. Enzymol. 15, 684 (1966).
S.G. Hales, K.S. Dodgson, D.F. White, N. Jones and G.K. Watson: ‘Initial stages in the biodegradation of the surfactant sodium dodecyltriethoxy sulfate by Pseudomonas sp. strain DES1’ Appl. Environ. Microbiol 44, 790 (1982).
J.M. Cloves, K.S. Dodgson, G.F. White and J.W. Fitzgerald: ‘Purification and properties of the P2 primary alkylsulphohydrolase of the detergent-degrading bacterium Pseudomonas C12B’ Biochem. J. 185, 23 (1980).
H.P. Schär and 0. Ghisalba: ‘Hyphomicrobium bacterial electrode for determination of monomethyl sulfate’ Biotechnol. Bioeng. 26, 897–901 (1985).
M. Gisin, S. Rösli, H.P. Schär and O. Ghisalba: unpublished results
H.P. Schär, P. Chemla and 0. Ghisalba: ‘Methanol dehydrogenase from Hyphomicrobium MS 223’ FEMS Microbiol. Lett. 26, 117 (1985).
J.A. Duine, J. Frank and J. Westerling: ‘Purification and properties of methanol dehydrogenase from Hyphomicrobium’ Biochim. Biophys. Acta 524, 277 (1978).
J.A. Duine and J. Frank: ‘The prosthetic group of methanol dehydrogenase’ Biochem. J. 187, 221 (1980).
M. Ameyama, M. Hiyashi. K. Matsushita, E. Shinagawa and O. Adachi: ‘Microbial production of pyrrolo-quinoline quinone’ Agric. Biol. Chem. 48, 561 (1984).
NT Gruenfeld, J.L. Stanton, A.M. Yuan, F.H. Ebetino, L.J. Browne, C. Gude and C.F. Huebner: ‘Angiotension converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acid derivatives’ J. Med. Chem. 26, 1277 (1983).
G.M. Ramos Tombo, H.P. Schär, W. Zimmermann and O. Ghisalba: in preparation.
C.S. Chen, Y. Fujimoto and C.J. Sih: ‘Bifunctional chiral synthons via microbiological methods. 1. Optically active 2,4-dimethylglutaric acid monomethyl esters’ J. Am. Chem. Soc. 103, 3580 (1981).
O. Ghisalba, J.A.L. Auden, T. Schupp and J. Niiesch: ‘The rifamycins: properties, biosynthesis, and fermentation’ in: E.J. Vandamme: Biotechnology of Industrial Antibiotics, Marcel” Dekker, New York (1984),p.281.
O. Ghisalba: ‘Biosynthesis of rifamycins (ansamycins) and microbial production of shikimate pathway precursors, intermediates and metabolites’ Chimia 39, 79 (1985).
Y. Ohshiro, S. Itoh, K. Kurokawa, J. Kato, T. Hirao and T. Agawa: ‘Micelle enhanced oxidation of amines by coenzyme PQQ’ Tetrahedron Lett. 24, 3465 (1983).
SI Itoh, N. Kato, Y. Ohshiro and T. Agawa: ‘Oxidative decarboxylation of α(-amino acids with coenzyme PQQ’ Tetrahedron Lett. 25, 4753 (1984).
S. Itoh, N. Kato, Y. Ohshiro and T. Agawa: ‘Catalytic oxidation of thiols by coenzyme PQQ’ Chemistry Lett. (J.C.S. Japan) 135 (1985).
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© 1986 D. Reidel Publishing Company
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Ghisalba, O., Schär, HP., Tombo, G.M.R. (1986). Applications of Microbes and Microbial Enzymes in Environmental Control and Organic Synthesis. In: Schneider, M.P. (eds) Enzymes as Catalysts in Organic Synthesis. NATO ASI Series, vol 178. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4686-6_14
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DOI: https://doi.org/10.1007/978-94-009-4686-6_14
Publisher Name: Springer, Dordrecht
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