Abstract
Reports of inflammatory reaction in uterine endometrium in the presence of an IUD have been unequivocal (Greenwald, 1965; Parr, 1969; Parr and Segal, 1966; Williams and Peck, 1977). An inflammatory reaction appears to be a common denominator in almost every animal: mouse (Doyle and Margolis, 1965; Parr and Segal, 1966); hamster (Saksena et al., 1974); goat (Janakiraman et al., 1970); cow (Hawk et al., 1968); pig (Gerrits et al, 1968); rabbit (Ledger and Bickley, 1966); and sheep (Hawk, 1967), and leads to infiltration of numerous polymorphonuclear leukocytes, mononuclear cells and macrophages in the endometrium and uterine lumen (El Sahwi and Moyer, 1971; Parr and Segal, 1966). These cells possibly release some embryotoxic material in the uterine lumen (El Sahwi and Moyer, 1971; Parr, 1969, 1970).
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Mehrotra, P.K., Srivastava, K. (1985). Inflammatory changes induced by lUDs in animal models. In: Hasson, H., Hafez, E.S.E., van Os, W.A. (eds) Biomedical Aspects of IUDs. Advances in Reproductive Health Care, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4896-9_3
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DOI: https://doi.org/10.1007/978-94-009-4896-9_3
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