Abstract
Although most naturally occurring cardiovascular diseases of man have been identified in one or more species of animals as well, the utility of all of these animals as research models is not established. Many of the so-called congenital defects are associated with non-cardiovascular defects as well. These may result in infertility, impotence and other problems which preclude, for all practical purposes, the breeding of these animals to obtain adequate numbers for research purposes. Some of the defects seen may be the result of a teratogenic insult rather than a genetic defect.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Detweiler, D.K., Patterson, D.F., The prevalence and types of cardiovascular disease in dogs. Annals New York Academy of Sciences, Vol. 127: 481–516, 1965.
Patterson, D.F., Congenital heart disease in the dog. Annals New York Academy of Sciences. Vol. 127: 541–569, 1956.
Patterson, D.F., Hare, W.C., Shive, R.J., Luginbuhl, H.R., Congenital malformations of the cardiovascular system associated with chromosomal abnormalities. A report of the clinical, pathologic and cytogenetic findings in 2 dogs. Zentralbl-Veterinaermed (A). 13 (8): 669–686, 1966.
Fontana, R.S., Edwards, J.E., Congential cardiac disease: A review of 357 cases studies pathologically, Saunders, Philadelphia, 1962.
Patterson, D.F., Haskins, M.E., Jezyk, P.F., Models of human genetic disease in domestic animals. Adv. Hum. Genet. 12: 263–339, 1982.
Clark, D.R., Knauer, K.W., Hobson, H.P., Gross, D.R., Humphries, J., Artificial pacemaker implantation for control of sinoatrial syncope in a miniature schnauzer. Southwestern Veterinarian. 28 (2): 101–107, 1975.
Hamlin, R.L., Smetzer, D.L., Breznock, E.M., Sino-Atrial Syncope in Miniature Schnauzers. JAVMA. 161: 1022–1028, 1972.
James, T.N., Congenital deafness and cardiac arrhythmias. Am. J. Cardiol. 19 (5): 627–643, 1967.
Ettinger, S.J., Suter, P.F., Canine Cardiology. W.B. Saunders Co., 1970.
Homburger, F., Baker, J.R., Nixon, C.W., Whitney, R., Primary generalized polymyopathy and cardiac necrosis in an inbred line of Syrian hamsters. Med. Exp. 6: 339, 1962.
Gertz, E.W., Cardiomyopathic Syrian hamster: A possible model of human disease. Progr. Exp. Tumor Res. 16: 242–260, 1972.
Kidd, P.M., Jones, A.L., Lemanski, L.F., Rudolph, A., Allen, L., Histological and Electron Microscopic stereological Study of the Myocardium of Newborn Genetically Cardiomyopathic Hamsters. J. Ultrastruc. Res. 76: 107–119, 1981.
Ma, T.S., Bailey, L.E., Excitation-contraction coupling in normal and myopathic hamster hearts Is identification of a calcium pool involved in contraction. Cardiovasc. Res. 13 (9): 487–498, 1979.
Button, C., Gross, D.R., Allert, J.A., Kitzman, J.V., Tricuspid atresia in a foal. JAVMA. 172 (7): 825–830, 1978.
Gross, D.R., Clark, D.R., McDonald, D.R., McCrady, J.D., Allert, J.A., Congestive heart failure associated with congenital aortic valvular insufficiency in a horse. Southwestern Vet. 30 (l): 27–34, 1977.
Alexander, A.F., Jenson, R., Pulmonary vascular pathology of high altitude induced pulmonary hypertension in cattle. Am. J. Vet. Res. 24: 1112–1122, 1963.
Hecht, H.H., Kuida, H., Lange, R.L., Thorne, J.L., Brown, A.M., Brisket disease II, clinical and hemodynamic observations in altitude dependent right heart failure of cattle. Am. J. Med. 32: 171–182, 1961.
Will, D.H., Alexander, A.F., Reeves, J.T., Grover, R.F., High altitude induces pulmonary hypertension in normal cattle. Circ. Res. 10: 172–177, 1962.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishers Dordrecht
About this chapter
Cite this chapter
Gross, D.R. (1985). Naturally Occurring Models of Cardiovascular Disease. In: Animal Models in Cardiovascular Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5006-1_11
Download citation
DOI: https://doi.org/10.1007/978-94-009-5006-1_11
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8717-9
Online ISBN: 978-94-009-5006-1
eBook Packages: Springer Book Archive