Abstract
It is generally accepted that white cells play an important role in the Shwartzman reaction (1, 2). Treatment of rabbits with nitrogen mustard to induce leukopenia blocked the induction of this reaction (2). Recent studies have provided support for the idea that blood monocytes may be crucial for the induction of the Shwartzman reaction. It has been shown that blood incubated with endotoxin in vitro generates a potent procoagulant activity that has now been identified as thromboplastin formed by monocytes (3, 4).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Horn RS, Collins RD: Studies on the pathogenesis of the generalized Shwartzman reaction. The role of granulocytes. Lab Invest 1968, 18: 101–107.
Lerner RG, Rapaport SI, Siemens JK, Spitzer JM: Disappearance of fibrinogen-131I after endotoxin. Am J Physiol 1968, 214: 532–537.
Lerner R, Cummings G: Endotoxin induced disseminated intravascular clotting: Evidence that it is mediated by neutrophil production of tissue factor. Thromb Res 1977, 11: 253–261.
Osterud B, Bjorklid E: The production and availability of tissue thromboplastin in cellular populations of whole blood exposed to various concentrations of endotoxin. Scand J Haematol 1982, 29: 175–184.
Thomas L, Good RA: Bilateral cortical necrosis of kidneys in cortisone-treated rabbits following injection of bacterial toxins. Proceedings of the Society for Experimental Biology and Medicine 1951, 76: 604–608.
Jacob HS: The role of activated complement and granulocytes in shock states and myocardial infarction. J Lab Clin Med 1981, 98: 645–653.
Robinson JA, Rapaport SI, Brown SF: Procoagulant activity of peritoneal leukocytes: effect of cortison and endotoxin. Am J Physiol 1978, 235: 333–337.
Boyum A: Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol Suppl 1956, 5: 9–15.
Osterud B, Lindahl U, Seljelid R: Macrophages produce blood coagulation factors. FEBS Letters 1980, 120: 41–43.
Friberger P, Kros M, Mellstam L: A quantitative endotoxin assay utilizing LAL and a cromogenic substrate. Prog Clin Biol Res 1982, 93: 195–206.
Yam LT, Li CY, Crosby WH: Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 1971, 55: 283–291.
Good RA, Thomas L: Studies on the generalized Shwartzman reaction II. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with thorotrast or trypan blue. J of Exp Med 1952, 96: 625–641.
Osterud B, Eskeland T: The mandatory role of complement in the endotoxin-induced synthesis of tissue thromboplastin in blood monocytes. FEBS Letters 1982, 149: 75–79.
Thompson J, van Furth R: The effect of glucocorticosteroids on the kinetics of mononuclear phagocytes. J of Exp Med 1970, 131: 429–442.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Østerud, B., Olsen, J.O., Tindall, A. (1985). The generalized Shwartzman reaction: effects of a glucocorticosteroid and endotoxin on thromboplastin synthesis by monocytes. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_73
Download citation
DOI: https://doi.org/10.1007/978-94-009-5020-7_73
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8723-0
Online ISBN: 978-94-009-5020-7
eBook Packages: Springer Book Archive