Abstract
The susceptibility of juvenile and adult Tupaias to infection with herpes simplex virus (HSV) was investigated in detail. It was found that HSV type 1 and 2 were highly pathogenic for juvenile and adult Tupaias. The state of viral latency was studied using the co-cultivation technique in those animals which had survived an acute infection. Infectious virus was recovered from the ganglia of chronically infected tree shrews. The susceptibility of juvenile Tupaias to several strains of temperature-sensitive mutants of HSV type 1 and 2 was also investigated. These experiments revealed that the animals survived an infection of different ts-mutants of HSV 1 and 2 and were protected against a superinfection of a lethal dose of wild-type HSV-1 and/or 2. The state of viral latency in these surviving animals was studied. It was found that infectious virus could only be recovered from the spleen of these animals. Genomic analysis of these newly recovered viruses showed significant changes as compared to their parental viruses. This finding led to the development of a model system for the generation of intertypic recombinants in vivo.
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References
Darai, G., Schwaier, A., Komitowski, D. and Munk, K. 1978. Experimental infection of Tupaia belangeri (tree shrews) with Herpes Simplex Virus types 1 and 2. J. infect. Dis., 137, 221–226.
Darai, G., Zöller, L., Matz, B., Schwaier, A., Flügel, R.M. and Munk, K. 1980. Experimental infection and the state of viral latency of adult Tupaia with Herpes Simplex Virus type 1 and 2 and infection of juvenile Tupaia with temperature-sensitive mutants of HSV type 2. Arch. Virol., 65, 311–318.
Darai, G., Scholz, J., Kurz, W. and Koch, H.G. 1983. Inter typic superinfection with Herpes Simplex Virus of Tupaia leads to reisolation of latent viruses with newly acquired lymphotropic properties. In “Herpes Virus of Man and Animal, Developments in Biological Standardization”. (Karger, Basel).
Goodpasture, E.W. and Teague, O. 1923. Transmission of herpes febrilis along nerves in experimentally infected rabbits. J. med. Res., 44, 139–184.
Mogensen, S.C., Teisner, B., Kerzel Andersen, H. 1974. Focal necrotic hepatitis in mice as a biological marker for differentiation of herpesvirus hominis type 1 and 2. J. gen. Virol., 25, 151–155.
Morse, L.S., Buchman, T.G., Roizman, B. and Schaffer, P.A. 1977. Anatomy of Herpes Simplex Virus DNA. IX. Apparent exclusion fo some parental DNA arrangements in the generation of intertypic (HSV1 × HSV2) recombinants. J. Virol., 24, 231–248.
Plummer, G., Hollingsworth, D.C., Phuangsab, A. and Bowling, C.P. 1970. Chronic infections by herpes simplex viruses and by the horse and cat herpesviruses. Infect. Immunol., 1, 351–355.
Preston, V.G., Davison, A.J., Marsden, H.S., Timbury, M.C., Subak-Sharpe, J.H. and Wilkie, N.M. 1978. Recombinants between Herpes Simplex Virus types 1 and 2: Analyses of genome structures and expression of immediate early polypeptides. J. Virol., 28, 499–517.
Scriba, M. 1977. Extraneural localisation of Herpes Simplex Virus in latently infected guinea pigs. Nature, 267, 529–531.
Stevens, J.G. 1975. Latent herpes simplex and the nervous system. Current Topics in Microbiology and Immunology, 70, 31–50.
Subak-Sharpe, J.H., Brown, S.M., Ritchie, D.A., Timbury, M.C., MacNab, J.C.M., Marsden, H.S. and Hay, J. 1974. Genetic and biochemical studies with herpesvirus. Cold Spring Harbor Symposium Quant. Biol., 39, 717–730.
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© 1984 ECSC, EEC, EAEC, Brussels-Luxembourg
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Darai, G., Scholz, H.J. (1984). Latency of Herpes Simplex Virus in Tree Shrew; Generation of Intertypic Recombinants of Herpes Simplex Virus in Vivo. In: Wittmann, G., Gaskell, R.M., Rziha, HJ. (eds) Latent Herpes Virus Infections in Veterinary Medicine. Current Topics in Veterinary Medicine and Animal Science, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5662-9_2
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DOI: https://doi.org/10.1007/978-94-009-5662-9_2
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