Abstract
Chronic inflammatory conditions often serve as promoting factors for the development of malignant tumors. Within the intestinal tract, enhanced carcinoma formation has been recorded in chronic infections such as tuberculosis and schistosomiasis and especially in cases of inflammatory bowel disease (IBD), including both ulcerative colitis (UC) and Crohn’s disease (CD). The dominant precursor lesion of colonic adenocarcinoma in the general population is the adenomal,2, but it has been estimated that about 1000 or 1 percent of all new cases of carcinoma in USA arise as a complication of chronic IBD3. Although these colitis-related tumors provide only a small fraction, they more commonly afflict younger patients, behave in a more aggressive fashion, and it appears that the large majority can be prevented. The present review will concentrate on the identification of epithelial dysplasia and its use in determining which patients with chronic colitis are more apt to have or develop a carcinoma.
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© 1982 Martinus Nijhoff Publishers, The Hague
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Goldman, H. (1982). Dysplasia and Carcinoma in Inflammatory Bowel Disease. In: Rachmilewitz, D. (eds) Inflammatory Bowel Diseases. Developments in Gastroenterology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7514-9_3
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DOI: https://doi.org/10.1007/978-94-009-7514-9_3
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