Abstract
Normal neonatal haemostasis is dependent on three interrelated factors: the vascular walls, the clotting proteins and the platelets. Impairment of one of these haemostatic components may lead to serious haemorrhage. The newborn, and especially the premature, is particularly susceptible to both haemorrhagic and thrombotic tendencies because of a physiological deficiency of platelet function, some coagulation factors and anticoagulants.
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References
Aballi, A.: Platelet counts in thriving premature infants. Pediatr. cs, 42: 685, 1968.
Adner, M.M. et al: Use of compatible platelet transfusions in the treatment of congenical isoimmune thrombocytopenic purpura.New Engl.J.Med. 280: 244, 1969.
Appleyard, W.J. et al: Venous platelet counts in low birthweight infants. Biol.Neon. 17: 30, 1971.
Bell, W.R. et al: Thrombocytopenia occurring during the administration of heparin. Ann. intern.Med. 85: 155, 1976.
Blajchman, M.A. et al: Shortening of the bleeding time in rabbitis of prostacycline generation by the vessel wall. J. clin.Invest. 63: 1026, 1979.
Bleyer, W.A. et al: The development of hemostatis in the human fetus and newborn infant. J.Pediat. 79: 838, 1971.
Borne, A.E.G.Kr. v. d., et al: A simple immunofluorescence test for the detection of platelet antibodies. Brit.J.Haemat. 39: 195, 1978.
Chessels, J.M. Bleeding problems in the newborn infant. Prog.Hemostasis Thromb. 2: 333, 1974.
Colman, R.W.: DIC: An approach. Amer.J.Med. 52: 679, 1972.
Corringan, J.: Thrombocytopenia: A laboratory sign of septicemia in infants and children. J.Pediat. 85: 219, 1974.
Deykin, D.: The clinical challenge of DIC. New Engl.J.Med. 283: 636, 1970.
Ekelund, H. et al: Fibrinolysis in newborns. Acta paediat. scand. 59: 33, 1970.
Fogel, B.J. et al: Platelet counts in healthy premature infants. J.Pediat. 73: 108, 1969.
Glader, B.E. et al: The bleeding neonate. Pediatrics 58: 548, 1976.
Goodhue, P.A. et al: ITP in pregnancy. Obstet.Gynec.Surv. 28: 671, 1973.
Gross, S.J.: Haemostasis in the Premature Infant. Clinics in Perinatology. Saunders, vol. 4, no. 2, 1977.
Hathaway, W.E.: The bleeding newborn. Ser.Haematol. 12: 175, 1975.
Hathaway, W.E.: DIC in the newborn. Pediatrics, 43: 233, 1969.
Hendriksson, P. et al: Factor XIII in the fetus and the newborn infant. Ped.Rev. 8: 789, 1974.
Heys, R.F.: Childbearing and ITP. J.Obstet.Gynaec.Brit.Cmwlth, 73: 205, 1966.
Hilgartner, M.W. et al: Factor XI in the neonate. J.Pediatrics 66: 747, 1965.
Holmberg, L. et al: Coagulation in the human fetus. Comparison with term newborn infants. J.Pediat. 85: 860, 1974.
Hrodek, 0.: Blood platelets in the newborn. Acta Univ.Carol., 22, 1966. 0
Jensen, A.H. et al: Evaluation of blood clotting factor levels in premature infants during the first ten days of life. Ped.Rev. 7: 638, 1973.
Laros, R.K. et al: Management of ITP during pregnancy. Amer.J.Obstet.Gynec. 122: 182, 1975.
Leeuwen, E.F. v. et al: Neutropenic en thrombocytopenic van de pasgeborene, veroozaakt door allo-antistoffen. Ned.T.Geneesk. 124: 393, 1980.
Leeuwen, E.F. v. et al: Neonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia. Brit. med.J. 281: 27, 1980.
Levine, P.H.: Platelet function test: Predictive value. New Engl.J.Med. 292: 1346, 1975.
Loghem, J.J. v. et al: Serological and genetical studies on a platelet antigen (Zw). Vox Sang. 4: 161, 1959.
Mahasandana, C. et al: Circulating anticoagulants in the newborn: Relation to hypercoagulability and the idiopathic respiratory distress syndrome. Ped.Rev. 7: 670, 1973.
Mcintosh, L.S. et al: Transfusions of antigenically compatible platelets for therapy and diagnosis of isoimmune neonatal thrombocytopenia. Ped.Rev. 6: 108, 1972.
Medoff, H.S.: Platelet counts in premature infants. J.Pediat. 64: 287, 1974.
Mull, M. et al: Altered platelet function in newborns. Ped.Rev. 4: 229, 1970.
Neame, P.B. et al: Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation. Blood, 56: 88, 1980.
Norriega-Guerra, L. et al: Pregnancy in patients with autoimmune thrombocytopenic purpura. Am.J.Obstet.Gynec. 15: 439, 1979.
Nossel, H.L. et al: A study of coagulation factor levels in women during labour and in their newborn infants. Thrombosis et Diathesis Haemorrh. 16: 185, 1966.
Pearson, H.A. et al: Isoimmune neonatal thrombocytopenic purpura: Clinical and therapeutic considerations. Blood, 123: 154, 1964.
Sell, E.J. et al: Platelet counts, fibrinogen concentration and Factor V and Factor VIII levels in healthy infants according to gestational age. J. Pediat. 82: 1028, 1973.
Shulman, N.R. et al: Immunoreactions involving platelets. J,clin.Invest. 40: 1597, 1961.
Sitar, A.L. et al: Management of isoimmune neonatal thrombocytopenia. Amer.J.Obstet.Gynec. 124: 39, 1976.
Straub, P.W.: A case against heparin therapy of intravascular coagulation. Throm.Diath.Haemorrh. 33: 107, 1974.
Stuart, M.: Storage pool deficiency in neonatal platelets. Ped.Rev. 11: 481, 1977.
Tancer, L.M.: Idiopathic thrombocytopenic purpura and pregnancy. Amer.J.Obstet.Gynec. 79: 148, 1960.
Territo, M. et al: Management of autoimmune thrombocytopenia in pregnancy and in the neonate. Obstet. and Gynec. 41: 579, 1973.
Weerdt, Ch.M. v. d.: Platelet antigens and isoimmunization. Thesis, Amsterdam, 1965.
Whaun, J.M.: The platelet of the newborn infant: 5-hydroxytryptamine uptake and release. Throm.Diath.Haemorrh. 30: 327, 1973.
Whaun, J.M. et al: The platelet of the newborn infant: Aggregation and adenine nucleotide release. Ped.Rev. 8: 41, 1974.
Woods, G.W. et al: DIC in the newborn. Amer.J.Dis.Child. 133: 44, 1979.
Zalneraitis, E.L. et al: Intracranial haemorrhage in utero as a complication of isoimmune thrombocytopenia. J.Pediat. 95:611, 1979.
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© 1982 Martinus Nijhoff Publishers, The Hague
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Biljlem, R.P.G.M. (1982). Some Aspects of Neonatal Thrombocytopenia. In: Sibinga, C.T.S., Das, P.C., Forfar, J.O. (eds) Paediatrics and Blood Transfusion. Developments in Hematology and Immunology, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7520-0_29
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DOI: https://doi.org/10.1007/978-94-009-7520-0_29
Publisher Name: Springer, Dordrecht
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