Abstract
Fractionation of the H2O-soluble HCN oligomers was performed by means of elution from active charcoal, chromatography on Sephadex G-15 and ion-exclusion HPLC. In contrast to previously published studies, at least eight different fractions were shown to posess different spectral properties after Sephadex G-15 column chromatography and to yield different sets of products upon hydrolysis. One of these fractions, which gave adenine and hypoxanthine after hydrolysis with 6 M HCl, was purified further by means of cation exclusion HPLC. In this way, a precursor of adenine (and hypoxanthine) has been isolated and is undergoing structural characterization. A tentative structure is suggested and a new reaction scheme leading to the synthesis of adenine from cis-diaminomaleonitrile without isomerization is proposed.
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© 1981 D. Reidel Publishing Company
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Voet, A.B., Schwartz, A.W. (1981). HCN Oligomerization - Isolation and Preliminary Characterization of a New Precursor of Adenine. In: Wolman, Y. (eds) Origin of Life. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8420-2_29
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DOI: https://doi.org/10.1007/978-94-009-8420-2_29
Publisher Name: Springer, Dordrecht
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