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Brain Tumor Microvasculature

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Brain Metastasis

Part of the book series: Metastasis: A Monograph Series ((METS,volume 2))

Abstract

Nearly a decade ago Darell Bigner and I, working with Milton Brightman, used the electron microscope to observe endothelial defects in hamster brain tumors induced by intracerebral inoculation of avian sarcoma virus (Brightman et al. 1971). We were impressed with the possible biologic and clinical significance of these defects and extended our findings to experimental gliomas in the dog (Vick and Bigner 1972b) and the rat (Yung et al. 1976). Subsequent studies by others of spontaneous human brain tumors, both primary and metastatic (Hirano and Matsui 1975; Waggener and Biggs 1976), and of chemically induced experimental gliomas (Cox et al. 1976) have led us to believe that endothelial abnormalities are characteristic of brain tumors. Moreover, we have become convinced that they are the prime structural basis for the well-known hyperpermeability of brain tumors to constituents of the blood vascular compartment and that their occurrence may have direct relevance for methods of effective chemotherapy (Vick et al. 1977).

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Authors
  1. Nicholas A. Vick
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Editor information

Editors and Affiliations

  1. Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York, USA

    Leonard Weiss Sc.D., M.D., Ph.D.

  2. Department of Radiation Therapy, Southern California Permanente Medical Group, Los Angeles, California, USA

    Harvey A. Gilbert M.D.

  3. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Jerome B. Posner M.D.

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© 1980 G.K. Hall & Co.

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Vick, N.A. (1980). Brain Tumor Microvasculature. In: Weiss, L., Gilbert, H.A., Posner, J.B. (eds) Brain Metastasis. Metastasis: A Monograph Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8799-9_7

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  • DOI: https://doi.org/10.1007/978-94-009-8799-9_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8801-9

  • Online ISBN: 978-94-009-8799-9

  • eBook Packages: Springer Book Archive

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