Abstract
The nature and chemical properties of the lymphocyte receptor for antigen have puzzled immunologists for over 70 years. On the basis of the exquisite binding specificity which antibodies showed for antigen, Ehrlich proposed in 1900 that the cell surface receptor for antigen must be antibody. The bulk of present evidence supporting this hypothesis has been obtained in an indirect manner by using antisera directed against immunoglobulins to inhibit binding of antigen by lymphocytes (Warner et al., 1970; Davie et al., 1971; Greaves and Hogg, 1971) and a variety of immune phenomena (Lesley and Dutton, 1970; Feldmann and Diener, 1971; Mason and Warner, 1970; Basten et al., 1971; Riethmuller et al., 1971).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bankhurst, A. D. and Warner, N. L. (1971). J. exp. Med. 134, 1005
Basten, A., Miller, J. F. A. P., Warner, N. L. and Pye, J. (1971). Nature New Biol 231, 104
Baur, S., Vitetta, E. S., Sherr, C. J., Schenkein, I. and Uhr, J. W. (1971). J. Immunol 106, 1133
Bayse, G. S. and Morrison, M. (1971). Arch. Biochem. Biophys. 145, 143
Bretscher, P. A. and Cohn, M. (1968). Nature, (London) 220, 444
Burnet, F. M. (1959). The Clonal Selection Theory of Immunity, Vanderbuilt University Press, New York
Byrt, P. and Ada, G. L. (1969). Immunology, 17, 503
Cheers, C. and Sprent, J. (1972) Proc. Fourth, Int. Conf. on Lymphatic Tissue and Germinal Centres in Immune Responses, in the press
Cone, R. E., Marchalonis, J. J. and Rolley, R. T. (1971). J. exp. Med. 134, 1373
Cone, R. E. and Marchalonis, J. J. (1972). In press
Cone, R. E., Sprent, J. and Marchalonis, J. J. (1972). In press
Davie, J. M., Rosenthal, A. S. and Paul, W. E. (1971). J. exp. Med. 134, 517
DeSousa, M. A. B., Parrot, D. M. V., and Pantelouris, E. M. (1969). Clin. exp. Immunol. 4, 637
Dowben, R. M. (1969). General Physiology—A Molecular Approach, p. 369. Harper and Row, New York
Edelman, G. M. and Benacerraf, B. (1962). Proc. Nat. Acad. Sci. U.S. 48, 1035
Edelman, G. M. and Marchalonis, J. J. (1967). In Methods in Immunology and Immuno-Chemistry, (Ed. by Williams, C. A. and Chase, M. W.), Vol. 1, p. 405. Academic Press Inc., New York
Edelman, G. M. and Gall, W. E. (1969). Annu. Rev. Biochem. 38, 415
Ehrlich, P. (1900). Croonian Lecture, Proc. Roy. Soc. B, 66, 424
Feldmann, M. and Diener, E. (1971). Nature, (London) 231, 183
Feldmann, M . (1972a) J. exp. Med., In the press
Feldmann, M . (1972b). J. exp. Med., In the press
Feldmann, M., Cone, R. E. and Marchalonis, J. J. (1972). In press
Greaves, M. F. and Hogg, N. W. (1971). In Cell Interactions and Receptor Antibodies in Immune Responses; (Ed. by Makela, O., Cross, A. and Kosunen, T. U.) p. 145. Academic Press Inc. New York
Greaves, M. F. and Bauminger, S. (1972). Nature New Biol. 235, 67
Hammerling, U. and Rajewsky, K. (1971), Eur. J. Immunol. 1, 447
Harris, A. W., Bankhurst, A. D., Mason, S. and Warner, N. L. (1972). In press
Klein, E. and Eskeland, T. (1971). In Cell Interactions and Receptor Antibodies in Immune Responses, (Ed. by Makela, O., Cross, A. and Kosunen, T. U.) p. 91. Academic Press, New York
Kiehn, E. D. and Holland, J. J. (1970). Biochemistry, 9, 1716
Langan, T. A. (1970). Adv. Biochem. Psychopharmacology, 3, 307
Lerner, R. A., McConahey, P. J., Jansen, I., and Dixon, F. J. (1972). J. exp. Med., 135, 136
Lesley, J. F. and Dutton, R. W. (1970). Science, 169, 487
Lesley, J. F., Kettman, J. R. and Dutton, R. W. (1971). J. exp. Med., 134, 618
Marchalonis, J. J. (1969). Biochem. J. 113, 299
Marchalonis, J. J., Atwell, J. L. and Cone, R. E. (1972a). Nature New Biol. 235, 240
Marchalonis, J. J., Cone, R. E. and Atwell, J. L. (1972b). J. exp. Med. 135, 956
Marchalonis, J. J., Cone, R. E. and Santer, V. (1971). Biochem. J. 124, 921
Marchalonis, J. J., and Gledhill, V. X. (1968). Nature, (London), 220, 608
Marchalonis, J. J. and Schonfeld, S. A. (1970). Biochim. Biophys. Acta, 221, 604
Mason, S. and Warner, N. (1970). J. Immunol. 104, 762
Miller, J. F. A. P. (1972). Int. Rev. Cytol., in press
Miller, J. F. A. P. and Michell, G. F. (1969). Transplant. Rev. 1, 3.
Miller, F. and Metzger, H. (1965). J, Biol. Chem., 240, 3325.
Mitchison, N. A., Rajewsky, K. and Taylor, R. B. (1970). In Developmental Aspects of Antibody Formation and Structure (Ed. by Sterzl, J. and Riha, I.) p. 547. Academic Press, New York
Nossal, G. J. V., Ada, G. L. and Austin, C. M. (1965). J. exp. Med. 121, 949
Nossal, G. J. V., Warner, N. L., Lewis, H. and Sprent, J. (1972). J. exp. Med. 135, 405.
O’Malley, B. W., Speisberg, T. C., Schräder, W. T., Chytil, F., and Steggles, A. W. (1972). Nature, (London), 235, 141
Parish, C. R. and Marchalonis, J. J. (1970). Anal. Biochem. 34, 436
Phillips, D. R. and Morrison, M. (1971). Biochemistry, 10, 1766
Rabellino, E., Colon, S., Grey, H. M. and Unanue, E. R. (1971). J. exp. Med. 133, 156
Raff, M. C. (1971). Transplant. Rev. 6, 52
Riethmuller, G., Rieber, E.-P. and Seeger, I. (1971). Nature, New Biol., 230, 248
Rolley, R. T. and Marchalonis, J. J. (1972a). Transplantation, 14, 118
Rolley, R. T. and Marchalonis, J. J. (1972b). Transplantation, in press
Sherr, C. J. and Uhr, J. W. (1970). J. exp. Med., 133, 901
Singer, S. J. and Doolittle, R. F. (1966). Science. 153, 13
Snell, S. D. and Stimpfling, J. H. (1966). In Biology of the Laboratory Mouse, (Ed. by Green, E. L.) p. 457. McGraw Hill, New York
Speisberg, T. C., Steggles, A. W. and O’Malley, B. W. (1971). J. Biol, Chem., 246, 4186
Sprent, J. and Miller, J. F. A. P. (1971). Nature New Biol. 234, 195
Stanley, P. and Haslam, E. A. (1971). Virology, 46, 764
Taylor, R. B., Duffus, W. P. H., Raff, M. C. and de Petris, S. (1971). Nature, New Biol 233, 225
Vitetta, E. S., Baur, S. and Uhr, J. W. (1971). J. exp. Med. 134, 242
Vitetta, E. S. and Uhr, J. W. (1972). J. Immunol 108, 577
Warner, N. L., Byrt, P. and Ada, G. L. (1970). Nature, (London) 226, 942
Warren, L. and Glick, M. C. (1968). J. Cell. Biol. 37, 729
Wilson, J. D., Nossal, G. J. V. and Lewis, H. (1972). Eur. J. Immunol, In press
Wld. Health Org. tech. Rep. Ser., 1969, No. 423. Cell-Mediated Immune Responses
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Marchalonis, J.J., Cone, R.E., Atwell, J.L., Rolley, R.T. (1973). Structure and Function of Lymphocyte Surface Immunoglobulin. In: Pollak, J.K., Lee, J.W. (eds) The Biochemistry of Gene Expression in Higher Organisms. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-2550-8_39
Download citation
DOI: https://doi.org/10.1007/978-94-010-2550-8_39
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-2552-2
Online ISBN: 978-94-010-2550-8
eBook Packages: Springer Book Archive