Abstract
Since its relatively recent promotion from the ranks of scavenger, the full range of known and possible mononuclear phagocyte functions in host defence has been the subject of many reviews and books1-8, and is quite beyond the scope of this article. A brief survey only will be given, therefore, of the properties of macrophages in so far as they may relate to immunological and non-immunological host defence mechanisms against cancer. First it is necessary to define our terms of reference:
Macrophages represent the differentiated tissue phase of a mononuclear phagocyte system9 (MPS) which includes their immediate precursors, the blood monocytes, and the promonocytes of the bone marrow, and it is to these three main classes of cells that I shall be referring. Functional properties by which these cells can be readily distinguished include strong adherence to glass, immune phagocytosis and several others described by Lejeune3.
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Eccles, S.A. (1978). Macrophages and cancer. In: Castro, J.E. (eds) Immunological Aspects of Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9418-4_6
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