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Clinical aspects of antibodies to double-stranded DNA

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Manual of Biological Markers of Disease

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Abstract

A broad spectrum of autoantibodies can be demonstrated in the serum of SLE patients. It was the observation by several investigators back in 1957 that there may exist a reaction between DNA and SLE sera [1–4] that started the serological studies of this disease. The earliest techniques used for detection of anti-dsDNA were relatively insensitive precipitation methods such as complement fixation and hemagglutination. At this moment specific and sensitive assays like radio immunoassay (RIA), immunofluorescence test on Crithidia luciliae (IFT) and enzyme linked immunosorbent assay (ELISA) are available for detecting and quantitating antibodies to DNA.

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Author information

Authors and Affiliations

  1. Department of Rheumatology, Dr. Daniel den Hoed Clinic, Rotterdam, The Netherlands

    A. J. G. Swaak

  2. Department of Autoimmune Diseases, Central Lab., Netherl. Red Cross Bloodtr. Serv. (CLB), Amsterdam, The Netherlands

    R. J. T. Smeenk

Authors
  1. A. J. G. Swaak
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  2. R. J. T. Smeenk
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Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1996 Kluwer Academic Publishers

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Swaak, A.J.G., Smeenk, R.J.T. (1996). Clinical aspects of antibodies to double-stranded DNA. In: van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1670-1_38

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  • DOI: https://doi.org/10.1007/978-94-011-1670-1_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-2219-1

  • Online ISBN: 978-94-011-1670-1

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