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Reversal of Multiple Drug Resistance (MDR) in Malaria by Reverse Isomers of Calcium Channel Blockers and its Possible Application to Cancer and MDR Parasitic Diseases

  • Chapter
Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

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Abstract

Several aspects of multiple drug resistance (MDR) have remained unclear since the original experiments demonstrated that toxic, anticancer drugs are pumped out of resistant cancer cells. It was unclear initially how a common mechanism could pump out a diverse series of anticancer drugs including adriamycin, actinomycin D, emetine, vincristine, vinblastine, chloroquine and VP-16. No structural relationship among the affected drugs was apparent.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, West Virginia University, Health Sciences, North Morgantown, West Virginia, 26506, USA

    K. Van Dyke & Z. Ye

  2. Cancer Biologics of America, 600 Perimeter Drive, Lexington, Kentucky, 40517, USA

    C. Van Dyke

Authors
  1. K. Van Dyke
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  2. Z. Ye
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  3. C. Van Dyke
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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© 1993 Springer Science+Business Media Dordrecht

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Van Dyke, K., Ye, Z., Van Dyke, C. (1993). Reversal of Multiple Drug Resistance (MDR) in Malaria by Reverse Isomers of Calcium Channel Blockers and its Possible Application to Cancer and MDR Parasitic Diseases. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_48

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_48

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4756-2

  • Online ISBN: 978-94-011-1725-8

  • eBook Packages: Springer Book Archive

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