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In Vitro Functional Correlates Of 5-HT,-Like Receptors

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Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

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Abstract

5-HT,-like receptors have been subdivided into 5 main subtypes denoted 5-HTA5-HTB5-HTc5-HTIDand 5-HTE. Each of these receptor subtypes has been cloned and the 2nd messenger-effector system to which they are linked identified. In additionin vitrofunctional correlates of the activation of these receptors in brain or peripheral tissues have been proposed and the evidence for these propositions is critically discussed in this review.

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References

  1. Bradley, P.B., Engel, G., Fenuik, W., Fozard, J.R., Humphrey, P.P.A., Middlemiss, D.N., Mylecharane, E.J., Richardson, B.P., and Saxena, P.R. (1986) ‘Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine’, Neuropharmacol. 25, 563–576.

    Article  CAS  Google Scholar 

  2. De Vivo, M. and Maayani, S. (1986) ‘Characterization of the 5hydroxytryptamine1Areceptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes’, J. Pharm. Exp. Ther. 238, 248–253.

    CAS  Google Scholar 

  3. Schoeffter, P. and Hoyer, D. (1988) ‘Centrally acting hypotensive agents with affinity for 5-HT1Abinding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus’, Br. J. Pharmacol. 85, 975–985.

    Article  Google Scholar 

  4. Dumuis, A., Sebben, M., and Bockaert, J. (1988) ‘Pharmacology of 5hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture’, Mol. Pharmacol. 33, 178–186.

    PubMed  CAS  Google Scholar 

  5. Markstein, R., Hoyer, D., and Engel, G. (1986) ‘5-HTIAreceptors mediate stimulation of adenylate cyclase in rat hippocampus’, Naunyn- Schmiedeberg’s Arch. Pharmacol. 333, 335–341.

    Article  CAS  Google Scholar 

  6. Schenker, A., Maayani, S., Weinstein, H., and Green, J.P. (1987) ‘Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes’, Mol. Pharmacol. 31, 357–367.

    Google Scholar 

  7. Andrade, R. and Chaput, Y. (1991) ‘The electrophysiology of serotonin receptor subtypes’ in S.J. Peroutka (ed.), Serotonin Receptor Subtypes: Basic and Clinical Aspects, Wiley-Liss, Inc., New York, pp. 103–124.

    Google Scholar 

  8. Claustre, Y., Benavides, J., and Scatton, B. (1991) ‘Potential mechanisms involved in the negative coupling between serotonin 5-HLAreceptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus’ J. Neurochem. 56, 1276–1285.

    Article  PubMed  CAS  Google Scholar 

  9. Radja, F., Daval, G, Hamon, M., and Verge, D. (1992) ‘Pharmacological and physiochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1Areceptor binding sites in the rat brain: a quantitative study’ J. Neurochem. 58, 1338–1346.

    Article  PubMed  CAS  Google Scholar 

  10. Marszaled, W., Scroggs, R.S., and Anderson, E.G. (1988) ‘Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptamine1psites’, J. Pharm. Exp. Ther. 247, 399–404.

    Google Scholar 

  11. Albert, P.R., Zhou, Q.Y., Van Tol, H.H.M, Bunzow, J.R., and Civelli, O. (1990) ‘Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1Areceptor gene’, J. Biol. Chem. 265, 5825–5832.

    Article  PubMed  CAS  Google Scholar 

  12. Kobilka, B.K., Frielle, T., Collins, S., Yang-Feng, T., Kobilka, T.S., Francke, U., Lefkowitz, R.J., and Caron, M.G. (1987) ‘An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins’, Nature 329, 75–79.

    Article  PubMed  CAS  Google Scholar 

  13. Fargin, A., Raymond, J.R., Lohse, M.J., Kobilka, B.K., Caron, M.G., and Lefkowitz, R.J. (1988) The genomic clone G-21 which resembles a betaadrenergic receptor sequence encodes the 5-HTAreceptor’, Nature 335, 358–360.

    Article  PubMed  CAS  Google Scholar 

  14. Fargin, A., Yamamoto, K., Cotecchia, S., Goldsmith, P.K., Spiegel, A.M., LaPetina, E.G., Caron, M.G., and Lefkowitz, R.J. (1991) ‘Dual coupling of the cloned 5-HT,, receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein’, Cell Signalling 3, 547–557.

    Article  PubMed  CAS  Google Scholar 

  15. Fargin, A., Raymond, J.R., Regan, J.W., Cotecchia, S., Lefkowitz, R.J., and Caron, M.G. (1989) ‘Effector coupling mechanisms of the cloned 5-HT,, receptor’, J. Biol. Chem. 264, 14848–14852.

    Article  PubMed  CAS  Google Scholar 

  16. Boddeke, H.W.G.M., Fargin, A., Raymond, J.R., Schoeffter, P., and Hoyer, D. (1992) ‘Agonist/antagonist interactions with cloned human 5-HT,, receptors: variations in intrinsic activity studies in transfected HeLa cells’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 345, 257–263.

    CAS  Google Scholar 

  17. Liu, Y.F. and Albert, P.R. (1991) ‘Cell-specific signalling of the 5-HTAreceptor’, J. Biol. Chem. 266, 23689–23697.

    Article  PubMed  CAS  Google Scholar 

  18. Bertin, B., Freissmuth, M., Breyer, R.M., Schultz, W., Strosberg, A.D., and Marullo, S. (1992) ‘Functional expression of the human serotonin 5-HT1Areceptor in escherichia coli’, J. Biol. Chem. 267, 8200–8206.

    Article  PubMed  CAS  Google Scholar 

  19. Sprouse, J. and Aghajanian, G.K. (1987) ‘Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists’, Synapse 1, 3–9.

    Article  PubMed  CAS  Google Scholar 

  20. Sawada, M. and Nagatsu, T. (1986) ‘Stimulation of the serotonin autoreceptor prevents the calcium-calmodulin-dependent increase of serotonin biosynthesis in rat raphe slices’, J. Neurochem. 46, 963–967.

    Article  PubMed  CAS  Google Scholar 

  21. Marszalec, W., Scroggs, R.S., and Anderson, E.G. (1988) ‘Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptaminelA sites’, J. Pharm. Exp. Ther. 247, 399–404.

    CAS  Google Scholar 

  22. Colino, A. and Halliwell, J.V. (1986) ‘8-OH-DPAT is a strong antagonist of 5-HT action in rat hippocampus’, Eur. J. Pharmacol. 130, 151–152.

    Article  PubMed  CAS  Google Scholar 

  23. Fozard, J.R. and Kilbinger, H. (1985) ‘8-OH-DPAT inhibits transmitter release from guinea-pig cholinergic neurones by activating 5-HT1Areceptors’, Br. J. Pharmacol. 86, 601P.

    Article  Google Scholar 

  24. Galligan, J.J. (1992) ‘Differential inhibition of cholinergie and noncholinergic neurogenic contractions by 5-hydroxytryptaminelA receptor agonists in guinea pig ileum’, J. Pharm. Exp. Ther. 260, 306–312.

    CAS  Google Scholar 

  25. Bouhelal, R., Smounya, L., and Bockaert, J. (1988) ‘5-HT1Areceptors are negatively coupled with adenylate cyclase in rat substantia nigra’, Eur. J. Pharmacol. 151, 189–196.

    Article  PubMed  CAS  Google Scholar 

  26. Senwen, K., Magnaldo, I., and Ponyssegur, J. (1988) ‘Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HTIBreceptors coupled to a G-protein’, Nature 335, 254–256.

    Article  Google Scholar 

  27. Maroteaux, L., Saudou, F., Amlaiky, N., Boschert, U., Plassat, J.L., and Hen, R. (1992) ‘Mouse 5HT1B serotonin receptor: Cloning, functional expression, and localization in motor control centers’, Neurobiol. 89, 3020–3024.

    CAS  Google Scholar 

  28. Adham, N., Romanienko, P., Hartig, P., Weinshank, R.L., and Branchek, T. (1991) ‘The rat 5-hydroxytryptamine1BReceptor is the species homologue of the human 5-hydroxytryptaminelDalpha receptor’, Mol. Pharmacol. 41, 1–7.

    Google Scholar 

  29. Middlemiss, D. N. and Hutson, P. H. (1990) ‘The 5HTIBreceptors’, Ann. NY. Acad. Sci. 600, 132–148.

    Article  PubMed  CAS  Google Scholar 

  30. Maura, G. and Raiteri, M. (1986) ‘Cholinergic terminals in rat hippocampus possess 5-HTIBreceptors mediating inhibition of acetylcholine release’, Eur. J. Pharmacol., 129, 333–337.

    Article  PubMed  CAS  Google Scholar 

  31. Molderings, G.J., Fink, K., Schlicker, E., and Gothert, M. (1987) ‘Inhibition of noradrenaline release via presynaptic 5-HTIBreceptors of the rat vena cava’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 336, 245–250.

    CAS  Google Scholar 

  32. Holt, S.E., Cooper, M., and Wyllie, J.H. (1986) ‘On the nature of the receptor mediating the action of 5-hydroxytryptamine in potentiating responses of the mouse urinary bladder strip to electrical stimulation’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 334, 333–340.

    CAS  Google Scholar 

  33. Wyllie, J.H. (1989) ‘Blockade by cyanopindolol of 5-HT receptors in mouse urinary bladder’ in Serotonin from Cell Biology to Pharmacology and Therapeutics, Serotonin Club, Florence, Italy, 56.

    Google Scholar 

  34. Conn, P.J., Sanders-Bush, E., Hoffman, B.J., and Hartig, P.R. (1986) ‘A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover’, Neurobiol. 83, 4086–4088.

    CAS  Google Scholar 

  35. Baez, M., Yu, L., and Cohen, M.L. (1990) ‘Pharmacological and molecular evidence that the contractile response to serotonin in rat stomach fundus is not mediated by activation of the 5-hydroxytryptaminelcreceptor’, Mol. Pharmacol. 38, 31–37.

    PubMed  CAS  Google Scholar 

  36. Cohen, M.L. (1989) ‘5-hydroxytryptamine and non-vascular smooth muscle contraction and relaxation’, in J.R. Fozard (ed.), The Peripheral Actions of 5-Hydroxytryptamine, Oxford University Press, Oxford, England, pp. 201–218.

    Google Scholar 

  37. Lubbert, H., Hoffman, B.J., Snutch, T.P., Van Dyke, T., Levine, A.J., Hartig, P.R., Lester, H.A., and Davidson, N. (1987) ‘cDNA cloning of a serotonin 5-HT,, receptor by electrophysiological assays of mRNA-injected xenopus oocytes’, PNAS 84, 4332–4336.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  38. Julius, D., MacDermott, A.B., Axel, R., and Jessell, T.M. (1988) ‘Molecular characterization of a functional cDNA encoding the serotonin lc receptor’, Science 241, 558–564.

    Article  PubMed  CAS  Google Scholar 

  39. Parker, I., Panicker, M.M., and Miledi, R., (1990) ‘Serotonin receptors expressed in xeonopus oocytes by mRNA from brain mediate a closing of K+membrane channels’, Mol. Brain Res. 7, 31–38.

    Article  PubMed  CAS  Google Scholar 

  40. Panicker, M.M., Parker, I., and Miledi, R. (1991)’Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA’, Neurobiol. 88, 2560–2562.

    CAS  Google Scholar 

  41. Hoger, J.H., Walter, A.E., Vance, D., Yu, L., Labarca, C., Lester, H.A., and Davidson, N. (1990) ‘Cloning, expression and modulation by serotonin of a mouse brain potassium channel’, Soc. Neurosci. Abst. 16, 671.

    Google Scholar 

  42. Foguet, M., Hoyer, D., Pardo, L.A., Parekh, A., Kluxen, F.W., Kalkman, H. O., Stuhmer, W., and Lubbert, H. (1992) ‘Cloning and functional characterisation of the rat stomach fundus serotonin receptor’, EMBO 11, 3481–3487.

    Article  CAS  Google Scholar 

  43. Sheldon, P.W. and Aghajanian, G.K. (1991) ‘Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: Evidence for mediation 5-HTCreceptors in pyramidal cells and 5-HT, receptors in interneurons’, Synapse 9, 208–218.

    Article  PubMed  CAS  Google Scholar 

  44. Hoyer, D. and Middlemiss, D.N. (1989) ‘Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain’, TIPS, 10, 130–132.

    PubMed  CAS  Google Scholar 

  45. Schoeffter, P., Waeber, C., Palacios, J.M., and Hoyer, D. (1988) ‘The 5hydroxytryptamine 5-HTDreceptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 337, 602–608.

    CAS  Google Scholar 

  46. Waeber, C., Schoeffter, P., Palacios, J.M., and Hoyer, D. (1989) ‘5-HTDreceptors in guinea-pig and pigeon brain. Radioligand binding and biochemical studies’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 340, 479–485.

    CAS  Google Scholar 

  47. Sumner, M.J. and Humphrey, P.P.A. (1990)’Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein’, Br. J. Pharmacol. 99, 219–220.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  48. Zgombick, J.M., Weinshank, R.L., Macchi, M., Schechter, L.E., Branchek, T.A., and Hartig, P.R. (1991) ‘Expression and pharmacological characterization of a canine 5-hydroxytryptamineDreceptor subtype’, Mol. Pharmacol. 40, 1036–1042.

    PubMed  CAS  Google Scholar 

  49. Hartig, P.R., Branchek, T.A., and Weinshank, R.L., (1992) ’ A subfamily of 5-HTDreceptor genes’, TIPS 13, 152–159.

    PubMed  CAS  Google Scholar 

  50. Maenhaut, C., Van Sande, J., Massart, C., Dinsart, C., Libert, F., Monferini, E., Giraldo, E., Ladinsky, H., Vassart, G., and Dumont, J.E. (1991) ’ The orphan receptor cDNA RDC4 encodes a 5-HTDserotonin receptor’, Biochem. Biophys. Res. Comm. 180, 1460–1468.

    Article  PubMed  CAS  Google Scholar 

  51. Weinshank, R.L., Branchek, T., and Hartig P.R. (1991) ‘Nucleic acid encoding 5-HT,D receptors and their antibodies’, Patent Application WO 911 7174-A1.

    Google Scholar 

  52. Middlemiss, D.N., Bremer, M.E., and Smith, S.M. (1988) ‘A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex’, Eur. J. Pharmacol. 157, 101–107.

    Article  PubMed  CAS  Google Scholar 

  53. Limberger, N., Deicher, R., and Starke, K. (1991) ‘Species differences in presynaptic serotonin autoreceptors: mainly 5-HTBbut possibly in addition 5-HTIDin the rat, 5-HT,, in the rabbit and guinea-pig brain cortex’, NaunynSchmiedeberg’s Arch Pharmacol. 343, 353–364.

    Article  CAS  Google Scholar 

  54. Schlicker, E., Fink, K., Gothert, M., Hoyer, D., Molderings, G., Roschke, I., and Schoeffter, P. (1989) The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HTDreceptor subtype’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 340, 45–51.

    CAS  Google Scholar 

  55. Feuerstein, T.J., Lupp, A., and Hertting, G. (1992) ‘Quantitative evaluation of the autoinhibitory feedback of release of 5-HT in the caudate nucleus of the rabbit where an endogenous tone on alphazadrenoceptors does not exist’, Neuropharmacol. 31, 15–23.

    Article  CAS  Google Scholar 

  56. Galzin, A.M. and Langer, S.Z. (1991) ‘Modulation of 5-HT release by presynaptic inhibitory and facilitatory 5-HT receptors in brain slices’, Adv. Biosci. 82, 59–62.

    CAS  Google Scholar 

  57. Wilkinson, L.O. and Middlemiss, D.N. (1992) ‘Metitepine distinguishes two receptors mediating inhibition of3H-5-hydroxytryptamine release in guinea pig hippocampus’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 345, 696–699.

    CAS  Google Scholar 

  58. Moret, C. and Briley, M. (1986) ‘Dihydroergocristine-induced stimulation of the 5-HT autoreceptor in the hypothalamus of the rat’, Neuropharmacol. 25, 169–174.

    Article  CAS  Google Scholar 

  59. Schoeffter, P. and Hoyer, D. (1990) ‘S-hydroxytryptamine (5-HT)-induced endothelium-dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HTIDreceptor subtype’, J. Pharm. Exp Ther. 252,387–395.

    CAS  Google Scholar 

  60. Gupta, P. (1992) ‘The endothelial 5-HT receptor that mediates relaxation in guinea-pig isolated jugular vein resembles the 5-HTIDsubtype’ Br. J. Pharmacol. 106, 703–709.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  61. Martin, G.R. and MacLennan, S.J. (1990) ‘Analysis of the 5-HT receptor in rabbit saphenous vein exemplifies the problems of using exclusion criteria for receptor classification’, Naunyn-Schmiedebcrg’s Arch Pharmacol. 342, 111–119.

    Article  CAS  Google Scholar 

  62. Ormandy, G.C., Wilson, D.J., Wren, P., Barrett, V.J., and Prentice, D.J. (1992) ‘Comparison of the 5-HTID-like receptors in the saphenous veins and CNS of the dog and rabbit’, Br. J. Pharmacol., in press.

    Google Scholar 

  63. Box, A.W., Van Heuven-Nolsen, D., Bos, E., Simoons, M.L., and Saxena, P. R. (1992) ‘S-hydroxytryptamine-induced contractions of the human isolated saphenous vein: Involvement of 5-HT2 and 5-HTID like receptors, and a comparison with grafted veins’, Naunyn-Schmiedeberg’s Arch. Pharmacol. 345, 500–508.

    Article  Google Scholar 

  64. Molderings, G.J., Werner, K., Likungu, J., and Gothert, M. (1990)’Inhibition of noradrenaline release from sympathetic nerves of the human saphenous vein via presynaptic 5-HT receptors similar to the 5-HT,D subtype’, NaunynSchmiedeberg’s Arch. Pharmacol. 342, 371–377.

    CAS  Google Scholar 

  65. Hamel, E. and Bouchard, D. (1991) ‘Contractile 5-HT, receptors in human isolated pial arterioles: correlation with 5-HTDbinding sites’, Br. J. Pharmacol. 102, 227–233.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  66. Heuring, R.E. and Peroutka, S.J. (1987) ‘Characterization of a novel3H-5hydroxytryptamine binding site subtype in bovine brain membranes’, J. Neurosci. 7, 894–903.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. Schoeffter, P. and Hoyer, D. (1989)’How selective is GR 43175? Interactions with functional 5-HT,A, 5-HT,A, 5-HT,, and 5-HT,D receptors’, NaunynSchmiedeberg’s Arch. Pharmacol. 340, 135–138.

    CAS  Google Scholar 

  68. Humphrey, P.P.A., Feniuk, W., Perren, M.J., Connor, H.E., Oxford, A.W., Coates, I.H., and Butina, D. (1988) ‘GR43175, a selective agonist for the 5HT,-like receptor in dog isolated saphenous vein’, Br. J. Pharmacol. 94, 1123–1132.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  69. Connor, H.E., Feniuk, W., and Humphrey, P.P.A. (1989) ‘Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT,-like receptor agonist’, Br. J. Pharmacol. 96, 379–387.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  70. Parsons, A.A. and Whalley, E.T. (1989) ‘Evidence for the presence of 5-HT,like receptors in rabbit isolated basilar arteries’, Eur. J. Pharmacol. 174, 189–196.

    Article  PubMed  CAS  Google Scholar 

  71. Gaw, A.J., Wadsworth, R.M., and Humphrey, P.P.A. (1990)’Pharmacological characterisation of postjunctional 5-HT receptors in cerebral arteries from the sheep’, Eur. J. Pharmacol. 179, 35–44.

    Article  PubMed  CAS  Google Scholar 

  72. Parsons, A.A., Whalley, E.T., Feniuk, W., Connor, H.E., and Humphrey, P. P.A., (1989) ‘5-HT,-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery’, Br. J. Pharmacol. 96, 434–449.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  73. Bond, R.A., Craig, D.A., Charlton, K.G., Ornstein, A.G., and Clarke, D.E. (1989) ‘Partial agonistic activity of GR43175 at the inhibitory prejunctional 5-HT,-like receptor in rat kidney’, J. Auton. Pharmac. 9, 201–210.

    Article  CAS  Google Scholar 

  74. Sahin-Erdemli, I., Hoyer, D., Stoll, A., Seiler, M.P., and Schoeffter, P. (1991) ‘5-HT,-like receptors mediate 5-hydroxytryptamine-induced contraction of guinea-pig isolated iliac artery’, Br. J. Pharmacol. 102, 386–390.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Chester, A.H., Martin, G.R., Bodelsson, M., Arneko-Noboin, B., Tadjkarimi, S., Tornebrandt, K., and Yacoub, M.H. (1990) ‘5-hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries’, Cardiovascular Res. 24, 932–937.

    Article  CAS  Google Scholar 

  76. Leonhardt, S., Herrick-Davis, K., and Titeler, M. (1989) ‘Detection of a novel serotonin receptor subtype (5-HTE) in human brain: Interaction with a GTP-binding protein’, J. Neurochem. 53, 465–471.

    Article  PubMed  CAS  Google Scholar 

  77. McAllister, G., Charlesworth, A., Snodin, C., Beer, M.S., Noble, A.J., Middlemiss, D.N., Iversen, L.L., and Whiting, P. (1992) ‘Molecular cloning of a serotonin receptor from human brain (5HT1E): A fifth 5HT1_ 1ikesubtype’, Neurobiol. 89, 5517–5521.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, CM20 2QR, UK

    D. N. Middlemiss, M. S. Beer & L. O. Wilkinson

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  1. D. N. Middlemiss
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  2. M. S. Beer
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  3. L. O. Wilkinson
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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Middlemiss, D.N., Beer, M.S., Wilkinson, L.O. (1993). In Vitro Functional Correlates Of 5-HT,-Like Receptors. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_9

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