Abstract
Significantly more SAA1 than SAA2 is routinely purified from the plasma of patients studied by this laboratory. Investigating the reason for this disparity, we have compared mRNA levels for SAAl and SAA2 in a patient whose ratio of purified SAA1/SAA2 was approximately six. Relative levels of SAA1 and SAA2 mRNA were determined by Northern analysis using isotype-specific oligonucleotide probes. Scanning densitometry of the resulting autoradiographs revealed a 2-fold predominance of SAA1 over SAA2 mRNA. Thus, a higher steady state level of SAA1 mRNA explains in part the predominance of the SAA1 isotype.
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© 1991 Springer Science+Business Media Dordrecht
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Kluve-Beckerman, B., Liepnieks, J., Benson, M.D. (1991). Differential Regulation of Human Serum Amyloid a Isoforms. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_31
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DOI: https://doi.org/10.1007/978-94-011-3284-8_31
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