Abstract
Using PET and D2-dopamine receptor ligands several research groups have examined central D2-dopamine receptor occupancy in schizophrenic patients during neuroleptic drug treatment. High D2-receptor occupancies have been found in the striatum which give support to the theory that the antipsychotic effect of neuroleptic drugs is related to blockade of central dopamine receptors. Studies that have been reported so far regarding the relation between drug effects and D2-receptor occupancy are reviewed. In conclusion, methods are now available to determine central dopamine receptor occupancy in relation to pharmacological effects. Such relationships may be useful for optimal clinical monitoring of neuroleptic drugs.
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Nordström, AL. (1991). Measurement of Dopamine Receptor Occupancy: Clinical Issues. In: Baron, J.C., Comar, D., Farde, L., Martinot, J.L., Mazoyer, B. (eds) Brain Dopaminergic Systems: Imaging with Positron Tomography. Developments in Nuclear Medicine, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3528-3_15
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DOI: https://doi.org/10.1007/978-94-011-3528-3_15
Publisher Name: Springer, Dordrecht
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